Editorial & Opinion
أعرض في EDS

Effects of pomegranate juice (Punica Granatum) on inflammatory biomarkers and complete blood count in patients with COVID-19: a structured summary of a study protocol for a randomized clinical trial.

التفاصيل البيبلوغرافية
العنوان: Effects of pomegranate juice (Punica Granatum) on inflammatory biomarkers and complete blood count in patients with COVID-19: a structured summary of a study protocol for a randomized clinical trial.
المؤلفون: Yousefi M; Department of Nutrition, School of Health and nutrition, Yasuj University of Medical Sciences, Yasuj, Iran., Sadriirani M; Department of Nutrition, School of Health and nutrition, Yasuj University of Medical Sciences, Yasuj, Iran., PourMahmoudi A; Department of Nutrition, School of Health and nutrition, Yasuj University of Medical Sciences, Yasuj, Iran., Mahmoodi S; Department of Nutrition, School of Health and nutrition, Yasuj University of Medical Sciences, Yasuj, Iran., Samimi B; Department of Nutrition, School of Health and nutrition, Yasuj University of Medical Sciences, Yasuj, Iran., Hosseinikia M; Department of Nutrition, School of Health and nutrition, Yasuj University of Medical Sciences, Yasuj, Iran., Saeedinezhad Z; Department of Internal Medicine, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran., Panahande SB; Department of Nutrition, School of Health and nutrition, Yasuj University of Medical Sciences, Yasuj, Iran. panahande.b@gmail.com.
المصدر: Trials [Trials] 2021 Apr 02; Vol. 22 (1), pp. 246. Date of Electronic Publication: 2021 Apr 02.
نوع المنشور: Clinical Trial Protocol; Letter
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, 2006-
مواضيع طبية MeSH: Fruit and Vegetable Juices* , Pomegranate* , Randomized Controlled Trials as Topic*, COVID-19/*therapy, Blood Cell Count ; Blood Sedimentation ; C-Reactive Protein/immunology ; COVID-19/blood ; COVID-19/immunology ; Double-Blind Method ; Hospitalization ; Humans ; Interleukin-6/immunology ; SARS-CoV-2
مستخلص: Objectives: This study is conducted to investigate efficacy of pomegranate juice on inflammatory biomarkers, C-reactive protein (CRP), interleukin 6(IL-6), erythrocyte sedimentation rate (ESR) and complete blood count (CBC) in hospitalized patients with mild to moderate coronavirus disease 2019 (COVID- 19).
Trial Design: This is a randomized, placebo-controlled, double-blind, parallel 2-arm (1:1 ratio) clinical trial.
Participants: Patients with COVID-19 admitted to hospitals in Yasuj City, Kohgiluyeh and Boyer-Ahmad Province, Iran.
Inclusion Criteria: Informed consent Patients 18 years of age or older Diagnosis of COVID-19 based on real-time polymerase chain reaction (RT-PCR) test EXCLUSION CRITERIA: Pregnancy or lactation Immunoglobulin A (IgA) level <61 mg/dl Disseminated intravascular coagulation or any other types of coagulopathy Severe congestive heart failure Participation in any clinical trial within 30 days prior to enrollment in this RCT Other contraindications determined by the specialist.
Intervention and Comparator: Intervention: 500 ml pomegranate juice and standard of care hospital treatment for COVID-19 Comparator: matching placebo containing 500 ml of red water and standard of care hospital treatment for COVID-19 Both intervention and comparator to be taken twice a day, after lunch and dinner, for 14 days.
Criteria for Discontinuing: Transfer of patients to intensive care unit (ICU) Death Unwillingness to continue participating in the study MAIN OUTCOMES: The main outcomes of this study are levels of inflammatory biomarkers, CRP, IL-6, ESR, and CBC after 14 days of treatment.
Randomization: Eligible patients will be randomly assigned into the intervention or control group in a 1:1 ratio. Randomization will be performed based on 8 permuted blocks with block sizes of 6 and they will be stratified according to sex and age categories. Randomization sequences will be prepared by the trial's pharmacist using computer-generated random numbers.
Blinding (masking): This study is a double-blind clinical trial (participant, researcher). The pomegranate juice and placebo juice are packaged in identical bottles, and the researcher and all the patients will be unaware of the study assignment until the end of the study. To ensure blinding, the randomization sequences will be kept in identical, opaque, sealed, and sequentially numbered envelopes.
Numbers to Be Randomized (sample Size): The calculated total sample size is 48 patients, with 24 patients assigned into each group.
Trial Status: The protocol is Version 1.0, on March 3, 2021. Recruitment started on February 28, 2021, and is anticipated to be completed by May 21, 2021.
Trial Registration: The Name of registering trial Effects of Pomegranate Juice (Punica Granatum) on Inflammatory Biomarkers and CBC in Patients with COVID-19: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Iranian registry of clinical trials (IRCT) Registration Number: IRCT20150711023153N2 Date of Trial Registration February 28, 2021, retrospectively registered FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials҆ website (Additional file 1). In the interest of expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol.
فهرسة مساهمة: Keywords: CBC; COVID-19; CRP; ESR; IL-6; Pomegranate Juice; Protocol; Randomized Controlled Trial
المشرفين على المادة: 0 (Interleukin-6)
9007-41-4 (C-Reactive Protein)
تواريخ الأحداث: Date Created: 20210403 Date Completed: 20210412 Latest Revision: 20220421
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8017515
DOI: 10.1186/s13063-021-05194-9
PMID: 33810808
قاعدة البيانات: MEDLINE
الوصف
تدمد:1745-6215
DOI:10.1186/s13063-021-05194-9