دورية أكاديمية
أعرض في EDS

Development and characterization of a chronic implant mouse model for vagus nerve stimulation.

التفاصيل البيبلوغرافية
العنوان: Development and characterization of a chronic implant mouse model for vagus nerve stimulation.
المؤلفون: Mughrabi IT; Institute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, United States., Hickman J; Departments of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, United States.; Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, United States., Jayaprakash N; Institute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, United States., Thompson D; Institute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, United States.; The Elmezzi Graduate School of Molecular Medicine, Manhasset, United States., Ahmed U; Institute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, United States., Papadoyannis ES; Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York University, New York, United States.; Department of Neuroscience and Physiology, Neuroscience Institute, Center for Neural Science, New York University School of Medicine, New York University, New York, United States.; Department of Otolaryngology, New York University School of Medicine, New York University, New York, United States.; Howard Hughes Medical Institute Faculty Scholar, New York University School of Medicine, New York University, New York, United States., Chang YC; Institute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, United States., Abbas A; Institute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, United States., Datta-Chaudhuri T; Institute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, United States., Chang EH; Institute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, United States., Zanos TP; Institute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, United States., Lee SC; Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, United States., Froemke RC; Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York University, New York, United States.; Department of Neuroscience and Physiology, Neuroscience Institute, Center for Neural Science, New York University School of Medicine, New York University, New York, United States.; Department of Otolaryngology, New York University School of Medicine, New York University, New York, United States.; Howard Hughes Medical Institute Faculty Scholar, New York University School of Medicine, New York University, New York, United States., Tracey KJ; Institute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, United States., Welle C; Departments of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, United States.; Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, United States., Al-Abed Y; Institute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, United States., Zanos S; Institute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, United States.
المصدر: ELife [Elife] 2021 Apr 06; Vol. 10. Date of Electronic Publication: 2021 Apr 06.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Electrodes, Implanted/*statistics & numerical data , Mice/*physiology , Vagus Nerve/*physiology , Vagus Nerve Stimulation/*instrumentation, Animals ; Electrophysiological Phenomena ; Male ; Mice, Inbred C57BL ; Models, Animal
مستخلص: Vagus nerve stimulation (VNS) suppresses inflammation and autoimmune diseases in preclinical and clinical studies. The underlying molecular, neurological, and anatomical mechanisms have been well characterized using acute electrophysiological stimulation of the vagus. However, there are several unanswered mechanistic questions about the effects of chronic VNS, which require solving numerous technical challenges for a long-term interface with the vagus in mice. Here, we describe a scalable model for long-term VNS in mice developed and validated in four research laboratories. We observed significant heart rate responses for at least 4 weeks in 60-90% of animals. Device implantation did not impair vagus-mediated reflexes. VNS using this implant significantly suppressed TNF levels in endotoxemia. Histological examination of implanted nerves revealed fibrotic encapsulation without axonal pathology. This model may be useful to study the physiology of the vagus and provides a tool to systematically investigate long-term VNS as therapy for chronic diseases modeled in mice.
Competing Interests: IM, JH, NJ, DT, UA, EP, YC, AA, TD, EC, TZ, SL, RF, CW, YA, SZ No competing interests declared, KT holds patents broadly related to this work. He has assigned all rights to the Feinstein Institutes for Medical Research.
(© 2021, Mughrabi et al.)
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معلومات مُعتمدة: DC12557 United States DC NIDCD NIH HHS; United States HHMI Howard Hughes Medical Institute; T32 GM008497 United States GM NIGMS NIH HHS; R01 HD088411 United States HD NICHD NIH HHS; R01 DC012557 United States DC NIDCD NIH HHS; U19 NS107616 United States NS NINDS NIH HHS
فهرسة مساهمة: Keywords: bioelectronic medicine; immunology; inflammation; long-term implant; mouse; neuroscience; vagus nerve stimulation
تواريخ الأحداث: Date Created: 20210406 Date Completed: 20210913 Latest Revision: 20240504
رمز التحديث: 20240504
مُعرف محوري في PubMed: PMC8051950
DOI: 10.7554/eLife.61270
PMID: 33821789
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.61270