دورية أكاديمية
[Purpura in a young woman with hyperthyroidism].
| العنوان: | [Purpura in a young woman with hyperthyroidism]. |
|---|---|
| عنوان ترانسليتريتد: | Purpura chez une jeune femme hyperthyroïdienne. |
| المؤلفون: | Giraud-Kerleroux L; Service de dermatologie, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94000 Créteil, France., Bernigaud C; Service de dermatologie, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94000 Créteil, France., Droumaguet C; Service d'endocrinologie, hôpital Henri-Mondor, AP-HP, Créteil, France., Thai LH; Service de médecine interne, hôpital Henri-Mondor, AP-HP, Créteil, France., Marciano-Fellous L; Service d'anatomopathologie, hôpital Henri-Mondor, AP-HP, Créteil, France., Thomas L; Centre régional de pharmacovigilance, hôpital Henri Mondor, AP-HP, Créteil, France., Charpentier C; Service de dermatologie, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94000 Créteil, France., Helbert-Davidson S; Service de médecine nucléaire, hôpital Henri-Mondor, AP-HP, Créteil, France., Fardet L; Service de dermatologie, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94000 Créteil, France., Hüe S; Laboratoire d'immunologie, hôpital Henri-Mondor, AP-HP, Créteil, France., Ingen-Housz-Oro S; Service de dermatologie, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94000 Créteil, France; UPEC, université Paris Est Créteil EpidermE, Créteil, France. Electronic address: saskia.oro@aphp.fr. |
| المصدر: | La Revue de medecine interne [Rev Med Interne] 2021 Jul; Vol. 42 (7), pp. 509-512. Date of Electronic Publication: 2021 Apr 10. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | French |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: France NLM ID: 8101383 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3122 (Electronic) Linking ISSN: 02488663 NLM ISO Abbreviation: Rev Med Interne Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Paris : Elsevier Original Publication: Paris : Baillière, [1980- |
| مواضيع طبية MeSH: | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis* , Hyperthyroidism*/chemically induced , Hyperthyroidism*/complications , Hyperthyroidism*/diagnosis , Purpura*, Adult ; Antibodies, Antineutrophil Cytoplasmic ; Antithyroid Agents/adverse effects ; Female ; Humans ; Propylthiouracil/adverse effects |
| مستخلص: | Introduction: Propylthiouracil (PTU) is a synthetic antithyroid drug that can induce ANCA-associated vasculitis. Observation: A 27-year-old woman diagnosed with Graves' disease was on PTU for the past 10 years. She developed purpuric lesions of the legs and on the tip of the nose diagnosed as vasculitis. ANCAs were positive, with anti-MPO and anti-PR3 on blood ELISA. After discontinuation of PTU, she was able to fully recover. Conclusion: All synthetic antithyroid drugs can induce ANCA-associated vasculitis, more often PTU. In most cases, antibodies are directed against MPO. Dual anti-MPO and anti-PR3 positivity is possible, but rare. The mechanism could be through an accumulation of PTU in neutrophils, altering the structure of MPO and making it immunogenic. PTU can also induce ANCA-free or lupus vasculitis, maculopapular rashes or urticaria. Many other drugs can induce ANCA-associated vasculitis. (Copyright © 2021 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.) |
| فهرسة مساهمة: | Keywords: ANCA; Anti-thyroid drugs; Anti-thyroïdiens de synthèse; Hyperthyroidism; Hyperthyroïdie; Propylthiouracil; Propylthiouracile; Vascularite; Vasculitis |
| المشرفين على المادة: | 0 (Antibodies, Antineutrophil Cytoplasmic) 0 (Antithyroid Agents) 721M9407IY (Propylthiouracil) |
| تواريخ الأحداث: | Date Created: 20210413 Date Completed: 20211124 Latest Revision: 20211124 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.revmed.2021.03.330 |
| PMID: | 33846035 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1768-3122 |
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| DOI: | 10.1016/j.revmed.2021.03.330 |