دورية أكاديمية
A double on the Rocs with a twist: Rocaglamide A targets multiple DEAD-box helicases to inhibit translation initiation.
| العنوان: | A double on the Rocs with a twist: Rocaglamide A targets multiple DEAD-box helicases to inhibit translation initiation. |
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| المؤلفون: | DiVita DJ; The Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA; Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210, USA; Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA., Kearse MG; The Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA; Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210, USA; Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA. Electronic address: michael.kearse@osumc.edu. |
| المصدر: | Cell chemical biology [Cell Chem Biol] 2021 Apr 15; Vol. 28 (4), pp. 431-433. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Comment |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, MA : Cell Press, 2016- |
| مواضيع طبية MeSH: | Benzofurans* , DEAD-box RNA Helicases*, DNA Helicases |
| مستخلص: | In this issue of Cell Chemical Biology, Chen et al. (2020) expand the target repertoire of rocaglamide A (RocA) to now include eIF4A2 and DDX3X, converting DEAD-box helicases into dominant-negative translation repressors. These results also highlight how cancer cell sensitivity to RocA is dependent on eIF4A and DDX3X levels. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2021 Elsevier Ltd. All rights reserved.) |
| التعليقات: | Comment on: Cell Chem Biol. 2021 Apr 15;28(4):475-486.e8. doi: 10.1016/j.chembiol.2020.11.008. (PMID: 33296667) |
| References: | Nature. 2014 Sep 25;513(7519):517-22. (PMID: 25209664) Nature. 2016 Jun 15;534(7608):558-61. (PMID: 27309803) Cell Chem Biol. 2021 Apr 15;28(4):475-486.e8. (PMID: 33296667) Mol Cell. 2019 Feb 21;73(4):738-748.e9. (PMID: 30595437) Cell Chem Biol. 2019 Nov 21;26(11):1586-1593.e3. (PMID: 31519508) Cell Rep. 2020 Feb 25;30(8):2481-2488.e5. (PMID: 32101697) Translation (Austin). 2016 Jan 04;4(1):e1137381. (PMID: 27335721) Wiley Interdiscip Rev RNA. 2018 Jul;9(4):e1473. (PMID: 29624880) Biochim Biophys Acta. 2015 Jul;1849(7):781-91. (PMID: 25234619) |
| معلومات مُعتمدة: | R00 GM126064 United States GM NIGMS NIH HHS |
| المشرفين على المادة: | 0 (Benzofurans) 84573-16-0 (rocaglamide) EC 3.6.4.- (DNA Helicases) EC 3.6.4.13 (DEAD-box RNA Helicases) |
| تواريخ الأحداث: | Date Created: 20210416 Date Completed: 20210720 Latest Revision: 20240803 |
| رمز التحديث: | 20240803 |
| مُعرف محوري في PubMed: | PMC11295116 |
| DOI: | 10.1016/j.chembiol.2021.03.014 |
| PMID: | 33861954 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2451-9448 |
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| DOI: | 10.1016/j.chembiol.2021.03.014 |