دورية أكاديمية
Cyanocobalamin and/or calcitriol mitigate renal damage-mediated by tamoxifen in rats: Implication of caspase-3/NF-κB signaling pathways.
| العنوان: | Cyanocobalamin and/or calcitriol mitigate renal damage-mediated by tamoxifen in rats: Implication of caspase-3/NF-κB signaling pathways. |
|---|---|
| المؤلفون: | Alshanwani AR; College of Medicine, Physiology Department, King Saud University, Saudi Arabia. Electronic address: aalshanawani@ksu.edu.sa., Mohamed AM; Therapeutic Chemistry Department, National Research Center, Cairo, Egypt; Biochemistry Department, College of Science, University of Jeddah, Jeddah, Saudi Arabia., Faddah LM; Pharmacology and Toxicology Department, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Shaheen S; College of Medicine, Anatomy Department, Stem Cell Unit, King Saud University, Riyadh, Saudi Arabia., Arafah MM; Pathology Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Hagar H; College of Medicine, Physiology Department, King Saud University, Saudi Arabia; College of Pharmacy, Pharmacology and Toxicology Department, Zagazig University, Zagazig, Egypt., Alhusaini AM; Pharmacology and Toxicology Department, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Alharbi FMB; College of Science, Biochemistry Department, King Saud University, Riyadh, Saudi Arabia., AlHarthii A; Pharmacology and Toxicology Department, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Badr AM; Pharmacology and Toxicology Department, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia; Pharmacology and Toxicology Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. |
| المصدر: | Life sciences [Life Sci] 2021 Jul 15; Vol. 277, pp. 119512. Date of Electronic Publication: 2021 Apr 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2008->: Amsterdam : Elsevier Original Publication: Oxford; Elmsford, N. Y. [etc.] Pergamon Press. |
| مواضيع طبية MeSH: | Calcitriol/*pharmacology , Tamoxifen/*adverse effects , Vitamin B 12/*pharmacology, Acute Kidney Injury/chemically induced ; Acute Kidney Injury/drug therapy ; Animals ; Apoptosis ; Blood Urea Nitrogen ; Calcitriol/metabolism ; Caspase 3/metabolism ; Creatinine/blood ; Female ; Kidney/pathology ; Kidney Diseases/drug therapy ; Kidney Diseases/metabolism ; Kidney Function Tests ; NF-kappa B/metabolism ; Nephritis/metabolism ; Rats ; Rats, Wistar ; Signal Transduction/drug effects ; Tamoxifen/pharmacology ; Tumor Necrosis Factor-alpha/metabolism ; Vitamin B 12/metabolism |
| مستخلص: | Aim: Tamoxifen (TAMO) is a chemotherapeutic drug used for the treatment of breast cancer. Nevertheless, there is a lack of information available in regarding its nephrotoxicity. The purpose of this work was to investigate the impact of cyanocobalamin (COB) and/or calcitriol (CAL) injections on TAMO-induced nephrotoxicity. Main Methods: Animals were allocated into five groups as follows: normal control group; TAMO (45 mg/kg) administered group; TAMO+COB (6mg/kg, i.p) treated group; TAMO+CAL (0.3 μg/kg, i.p) treated group; TAMO+COB+CAL combination groups. Key Findings: Renal injury induced by TAMO was confirmed by the alteration in renal function parameters in the serum (urea and creatinine), as well as in the urine (creatinine clearance, total protein and albumin). These results were supported by histopathological examination. Upregulation of renal inflammatory parameters; tumor necrosis factor (TNF)-α, interleukin (IL)-6, C-reactive protein (CRP); and transforming growth factor (TGF)-β1 as well as in protein expression of nuclear factor-kappa B (NF-κB) and cleaved caspase-3 were observed to a greater extent in the TAMO-treated rats compared with the control. Renal fibrosis was also evidenced by a elevation in renal L-hydroxyproline level as well as by histomorphological collagen deposition in TAMO-treated groups compared to the control group. Administration of COB and/or CAL concurrently with TAMO significantly ameliorated the deviation in the above-studied parameters and improved the histopathological renal picture. Significance: Inhibition of NF-κβ-mediated inflammation and caspase-3-induced apoptosis are possible renoprotective mechanisms of COB and/or CAL against TAMO nephrotoxicity, which was more noticeable in the TAMO group treated with the combination of the two vitamins in question. (Copyright © 2021 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Calcitriol; Caspase-3; Cyanocobalamin; Nephrotoxicity; Nuclear factor-kappa B; Tamoxifen |
| المشرفين على المادة: | 0 (NF-kappa B) 0 (Tumor Necrosis Factor-alpha) 094ZI81Y45 (Tamoxifen) AYI8EX34EU (Creatinine) EC 3.4.22.- (CASP3 protein, human) EC 3.4.22.- (Caspase 3) FXC9231JVH (Calcitriol) P6YC3EG204 (Vitamin B 12) |
| تواريخ الأحداث: | Date Created: 20210416 Date Completed: 20210622 Latest Revision: 20210622 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.lfs.2021.119512 |
| PMID: | 33862116 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder كن أول من يترك تعليقا!