دورية أكاديمية
Microvascular changes associated with epilepsy: A narrative review.
| العنوان: | Microvascular changes associated with epilepsy: A narrative review. |
|---|---|
| المؤلفون: | van Lanen RH; Department of Neurosurgery, Maastricht University Medical Center, Maastricht, the Netherlands.; School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands., Melchers S; Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands., Hoogland G; Department of Neurosurgery, Maastricht University Medical Center, Maastricht, the Netherlands.; School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands.; Academic Center for Epileptology, Maastricht University Medical Center, Maastricht, the Netherlands., Schijns OE; Department of Neurosurgery, Maastricht University Medical Center, Maastricht, the Netherlands.; School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands.; Academic Center for Epileptology, Maastricht University Medical Center, Maastricht, the Netherlands., Zandvoort MAV; School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands.; Department of Molecular Cell Biology, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, the Netherlands.; School for Cardiovascular Diseases, Maastricht University Medical Center, Maastricht, the Netherlands., Haeren RH; Department of Neurosurgery, Maastricht University Medical Center, Maastricht, the Netherlands.; Department of Neurosurgery, Helsinki University Central Hospital, Helsinki, Finland., Rijkers K; Department of Neurosurgery, Maastricht University Medical Center, Maastricht, the Netherlands.; School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands.; Academic Center for Epileptology, Maastricht University Medical Center, Maastricht, the Netherlands. |
| المصدر: | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2021 Oct; Vol. 41 (10), pp. 2492-2509. Date of Electronic Publication: 2021 Apr 17. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: SAGE Publications Country of Publication: United States NLM ID: 8112566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-7016 (Electronic) Linking ISSN: 0271678X NLM ISO Abbreviation: J Cereb Blood Flow Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : Thousand Oaks, CA : SAGE Publications Original Publication: New York : Raven Press, c1981- |
| مواضيع طبية MeSH: | Blood-Brain Barrier/*physiopathology , Epilepsy/*blood , Microcirculation/*physiology, Female ; Humans ; Male |
| مستخلص: | The blood-brain barrier (BBB) is dysfunctional in temporal lobe epilepsy (TLE). In this regard, microvascular changes are likely present. The aim of this review is to provide an overview of the current knowledge on microvascular changes in epilepsy, and includes clinical and preclinical evidence of seizure induced angiogenesis, barriergenesis and microcirculatory alterations. Anatomical studies show increased microvascular density in the hippocampus, amygdala, and neocortex accompanied by BBB leakage in various rodent epilepsy models. In human TLE, a decrease in afferent vessels, morphologically abnormal vessels, and an increase in endothelial basement membranes have been observed. Both clinical and experimental evidence suggests that basement membrane changes, such as string vessels and protrusions, indicate and visualize a misbalance between endothelial cell proliferation and barriergenesis. Vascular endothelial growth factor (VEGF) appears to play a crucial role. Following an altered vascular anatomy, its physiological functioning is affected as expressed by neurovascular decoupling that subsequently leads to hypoperfusion, disrupted parenchymal homeostasis and potentially to seizures". Thus, epilepsy might be a condition characterized by disturbed cerebral microvasculature in which VEGF plays a pivotal role. Additional physiological data from patients is however required to validate findings from models and histological studies on patient biopsies. |
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| فهرسة مساهمة: | Keywords: Angiogenesis; epilepsy; microvascular density; temporal lobe epilepsy; vascular endothelial growth factor |
| تواريخ الأحداث: | Date Created: 20210419 Date Completed: 20211119 Latest Revision: 20211119 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC8504411 |
| DOI: | 10.1177/0271678X211010388 |
| PMID: | 33866850 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1559-7016 |
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| DOI: | 10.1177/0271678X211010388 |