دورية أكاديمية
Evaluation of LKB1 and Serine-Glycine Metabolism Pathway Genes (SHMT1 and GLDC) Expression in AML.
| العنوان: | Evaluation of LKB1 and Serine-Glycine Metabolism Pathway Genes (SHMT1 and GLDC) Expression in AML. |
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| المؤلفون: | Mezginejad F; Laboratory Hematology & Blood Banking, Department of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Mohammadi MH; Laboratory Hematology & Blood Banking, Department of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; HSCT Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Khadem P; Laboratory Hematology & Blood Banking, Department of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Farsani MA; Laboratory Hematology & Blood Banking, Department of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; HSCT Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Department of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Darband St, Qods Sq, Tehran, Iran. |
| المصدر: | Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion [Indian J Hematol Blood Transfus] 2021 Apr; Vol. 37 (2), pp. 249-255. Date of Electronic Publication: 2020 Aug 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Indian Society of Hematology and Blood Transfusion Country of Publication: India NLM ID: 9425818 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0971-4502 (Print) Linking ISSN: 09714502 NLM ISO Abbreviation: Indian J Hematol Blood Transfus Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: [Mumbai] : Springer India : Indian Society of Hematology and Blood Transfusion Original Publication: Bombay : Indian Society of Hematology and Blood Transfusion |
| مستخلص: | LKB1 is a significant tumor suppressor and epigenetic regulator playing a vital role in different types of cancers. SHMT1 and GLDC are two critical genes of the epigenetic pathway influenced by LKB1. As epigenetic is the major cause of AML pathogenesis, this study aimed at investigating LKB1, SHMT1, and GLDC gene expression levels in acute myeloid leukemia patients. The present study was conducted on LKB1, SHMT1, and GLDC gene expression levels in 60 de novo AML samples and 30 normal controls using real-time RT-PCR. The results showed that LKB1 and SHMT1 have respectively a significantly lower ( P < 0.05) and higher ( P < 0.05) expression level than that of normal controls. Furthermore, the correlation between LKB1 with SHMT1 and GLDC was significant and positive ( P value: 0.015, r: 0.299). Positive findings confirm that metabolic pathways alongside the LKB1 association drive the epigenetic axis and its substrate production. Therefore, it can be concluded that the newly-discovered pathway in the pathogenesis of this disease provides new insights into the design of therapeutic targets. Competing Interests: Conflict of interestThe authors declare that they have no competing interests. (© Indian Society of Hematology and Blood Transfusion 2020.) |
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| فهرسة مساهمة: | Keywords: AML; GLDC; LKB1; SHMT1 |
| تواريخ الأحداث: | Date Created: 20210419 Latest Revision: 20220402 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC8012466 |
| DOI: | 10.1007/s12288-020-01329-1 |
| PMID: | 33867731 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 0971-4502 |
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| DOI: | 10.1007/s12288-020-01329-1 |