دورية أكاديمية
[The Configuration of Tadalafil and Tadalafil Analogues Found in Dietary Supplements].
| العنوان: | [The Configuration of Tadalafil and Tadalafil Analogues Found in Dietary Supplements]. |
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| المؤلفون: | Fukiwake T; Chiba Prefectural Institute of Public Health., Yamazaki M; Chiba Prefectural Institute of Public Health., Takahashi K; Chiba Prefectural Institute of Public Health., Doi T; Osaka Institute of Public Health., Kawaguchi M; Osaka Institute of Public Health., Enomoto K; Chiba Prefectural Institute of Public Health., Yoshino H; Chiba Prefectural Institute of Public Health., Uchimoto K; Chiba Prefectural Institute of Public Health., Nishimura M; Chiba Prefectural Institute of Public Health. |
| المصدر: | Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan [Shokuhin Eiseigaku Zasshi] 2021; Vol. 62 (2), pp. 65-72. |
| نوع المنشور: | Journal Article |
| اللغة: | Japanese |
| بيانات الدورية: | Publisher: Food Hygienic Society Country of Publication: Japan NLM ID: 0142214 Publication Model: Print Cited Medium: Print ISSN: 0015-6426 (Print) Linking ISSN: 00156426 NLM ISO Abbreviation: Shokuhin Eiseigaku Zasshi Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Tokyo : Food Hygienic Society Original Publication: Tokyo, Nippon Shokuhin Eisei Gakkai. |
| مواضيع طبية MeSH: | Dietary Supplements*/analysis, Chromatography, High Pressure Liquid ; Cyclic Nucleotide Phosphodiesterases, Type 5 ; Magnetic Resonance Spectroscopy ; Tadalafil |
| مستخلص: | This study determined the configuration of the isomers of tadalafil, nortadalafil, and homotadalafil in dietary supplements. The products purchased over the Internet studied included a honey product and a tablet, which contained tadalafil, and a candy, which contained nortadalafil and homotadalafil. Each of the pharmaceutical ingredients isolated from the products was measured with circular dichroism (CD).As a result, the CD spectrum of each isolated pharmaceutical ingredient was found to align with the standard CD spectrum of the 6R,12aR isomer, confirmed that each isolated tadalafil or tadalafil analogue included in a 6R,12aR isomer. According to a report, among the stereoisomers of tadalafil, the 6R,12aR isomers have the most potent inhibitory activities of phosphodiesterase-type-5. From the report, the potential strength of the inhibitory activity of the 6R,12aR isomers of nortadalafil and homotadalafil was suggested. Therefore, it seemed that the 6R,12aR isomer often used in the product. |
| فهرسة مساهمة: | Keywords: circular dichroism (CD) spectrum; dietary supplement; homotadalafil; nortadalafil; tadalafil |
| المشرفين على المادة: | 742SXX0ICT (Tadalafil) EC 3.1.4.35 (Cyclic Nucleotide Phosphodiesterases, Type 5) |
| تواريخ الأحداث: | Date Created: 20210422 Date Completed: 20210423 Latest Revision: 20210423 |
| رمز التحديث: | 20231215 |
| DOI: | 10.3358/shokueishi.62.65 |
| PMID: | 33883338 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0015-6426 |
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| DOI: | 10.3358/shokueishi.62.65 |