دورية أكاديمية
أعرض في EDS

Conserved genetic signatures parcellate cardinal spinal neuron classes into local and projection subsets.

التفاصيل البيبلوغرافية
العنوان: Conserved genetic signatures parcellate cardinal spinal neuron classes into local and projection subsets.
المؤلفون: Osseward PJ 2nd; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.; Neurosciences Graduate Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA., Amin ND; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Moore JD; Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, MA, USA., Temple BA; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.; Neurosciences Graduate Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA., Barriga BK; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.; Biological Sciences Graduate Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA., Bachmann LC; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Beltran F Jr; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Gullo M; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Clark RC; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Driscoll SP; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Pfaff SL; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. pfaff@salk.edu., Hayashi M; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
المصدر: Science (New York, N.Y.) [Science] 2021 Apr 23; Vol. 372 (6540), pp. 385-393.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
أسماء مطبوعة: Publication: : Washington, DC : American Association for the Advancement of Science
Original Publication: New York, N.Y. : [s.n.] 1880-
مواضيع طبية MeSH: Neural Pathways* , Transcriptome*, Neurons/*physiology , Spinal Cord/*cytology, Animals ; Cervical Cord/cytology ; Female ; Male ; Mice ; Motor Neurons/physiology ; Proprioception ; RNA-Seq ; Sensory Receptor Cells/physiology ; Single-Cell Analysis ; Spatial Analysis ; Spinal Cord/embryology ; Transcription Factors/genetics ; Transcription Factors/metabolism
مستخلص: Motor and sensory functions of the spinal cord are mediated by populations of cardinal neurons arising from separate progenitor lineages. However, each cardinal class is composed of multiple neuronal types with distinct molecular, anatomical, and physiological features, and there is not a unifying logic that systematically accounts for this diversity. We reasoned that the expansion of new neuronal types occurred in a stepwise manner analogous to animal speciation, and we explored this by defining transcriptomic relationships using a top-down approach. We uncovered orderly genetic tiers that sequentially divide groups of neurons by their motor-sensory, local-long range, and excitatory-inhibitory features. The genetic signatures defining neuronal projections were tied to neuronal birth date and conserved across cardinal classes. Thus, the intersection of cardinal class with projection markers provides a unifying taxonomic solution for systematically identifying distinct functional subsets.
(Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
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معلومات مُعتمدة: K99 HD096512 United States HD NICHD NIH HHS; T32 GM007240 United States GM NIGMS NIH HHS; T32 MH019938 United States MH NIMH NIH HHS; U19 NS112959 United States NS NINDS NIH HHS
المشرفين على المادة: 0 (Transcription Factors)
تواريخ الأحداث: Date Created: 20210423 Date Completed: 20210507 Latest Revision: 20211126
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC8612134
DOI: 10.1126/science.abe0690
PMID: 33888637
قاعدة البيانات: MEDLINE
الوصف
تدمد:1095-9203
DOI:10.1126/science.abe0690