دورية أكاديمية
أعرض في EDS

Diagnostic potential of hypoxia-induced genes in liquid biopsies of breast cancer patients.

التفاصيل البيبلوغرافية
العنوان: Diagnostic potential of hypoxia-induced genes in liquid biopsies of breast cancer patients.
المؤلفون: Peiró CHF; Laboratório de Análises Clínicas do Centro Universitário Saúde ABC, Faculdade e Medicina do ABC, Av. Lauro Gomes, 2000, Santo André, SP, CEP 09060-870, Brazil., Perez MM; Laboratório de Análises Clínicas do Centro Universitário Saúde ABC, Faculdade e Medicina do ABC, Av. Lauro Gomes, 2000, Santo André, SP, CEP 09060-870, Brazil., de Aquino GSA; Laboratório de Análises Clínicas do Centro Universitário Saúde ABC, Faculdade e Medicina do ABC, Av. Lauro Gomes, 2000, Santo André, SP, CEP 09060-870, Brazil., Encinas JFA; Laboratório de Análises Clínicas do Centro Universitário Saúde ABC, Faculdade e Medicina do ABC, Av. Lauro Gomes, 2000, Santo André, SP, CEP 09060-870, Brazil., Sousa LVA; Laboratório de Epidemiologia e Análise de Dados, FMABC, Santo André, SP, Brazil., da Veiga GL; Laboratório de Análises Clínicas do Centro Universitário Saúde ABC, Faculdade e Medicina do ABC, Av. Lauro Gomes, 2000, Santo André, SP, CEP 09060-870, Brazil., Del Giglio A; Departamento de Oncologia e Hematologia do Centro Universitário Saúde ABC-Faculdade de Medicina do ABC, Santo André, SP, Brazil., Fonseca FLA; Laboratório de Análises Clínicas do Centro Universitário Saúde ABC, Faculdade e Medicina do ABC, Av. Lauro Gomes, 2000, Santo André, SP, CEP 09060-870, Brazil.; Instituto de Ciências Farmacêuticas, Universidade Federal de São Paulo (UNIFESP), Diadema, SP, Brazil., da Costa Aguiar Alves B; Laboratório de Análises Clínicas do Centro Universitário Saúde ABC, Faculdade e Medicina do ABC, Av. Lauro Gomes, 2000, Santo André, SP, CEP 09060-870, Brazil. bcaalves@uol.com.br.
المصدر: Scientific reports [Sci Rep] 2021 Apr 22; Vol. 11 (1), pp. 8724. Date of Electronic Publication: 2021 Apr 22.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Gene Expression Regulation, Neoplastic*, Breast Neoplasms/*diagnosis , Breast Neoplasms/*genetics , Carbonic Anhydrase IX/*genetics , Cell Hypoxia/*genetics , Glucose Transporter Type 1/*genetics , Hypoxia-Inducible Factor 1, alpha Subunit/*genetics , Liquid Biopsy/*methods, Case-Control Studies ; Female ; Humans ; Middle Aged
مستخلص: In tumor cells, higher expression of glucose transporter proteins (GLUT) and carbonic anhydrases (CAIX) genes is influenced by hypoxia-induced factors (HIF).Thus, we aimed to study the expression profile of these markers in sequential peripheral blood collections performed in breast cancer patients in order to verify their predictive potential in liquid biopsies. Gene expressions were analyzed by qPCR in tumor and blood samples from 125 patients and 25 healthy women. Differential expression was determined by the 2(-ΔCq) method. Expression of HIF-1α and GLUT1 in the blood of breast cancer patients is significantly higher (90-91 and 160-161 fold increased expression, respectively; p < 0.0001) than that found in healthy women. Their diagnostic power was confirmed by ROC curve. CAIX is also more expressed in breast cancer women blood, but its expression was detected only in a few samples. But none of these genes could be considered predictive markers. Therefore, evaluation of the expression of HIF-1α and GLUT1 in blood may be a useful laboratory tool to complement the diagnosis of breast cancer, in addition to being useful for follow-up of patients and of women with a family history of breast cancer.
References: Br J Cancer. 2010 Feb 2;102(3):561-9. (PMID: 20051957)
J Clin Med. 2020 Jan 10;9(1):. (PMID: 32071283)
J Cancer Res Clin Oncol. 2013 May;139(5):747-54. (PMID: 23358720)
Metabolites. 2018 Feb 28;8(1):. (PMID: 29495652)
Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12596-601. (PMID: 9770531)
Nat Rev Cancer. 2005 Aug;5(8):591-602. (PMID: 16056258)
Asia Pac J Clin Nutr. 2014;23(1):174-80. (PMID: 24561986)
J Cell Physiol. 2005 Mar;202(3):654-62. (PMID: 15389572)
Genes Cancer. 2013 Nov;4(11-12):513-23. (PMID: 24386511)
Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5429-38. (PMID: 25453096)
Pol J Pathol. 2015 Dec;66(4):337-46. (PMID: 27003764)
Drug Resist Updat. 2011 Jun;14(3):191-201. (PMID: 21466972)
Mini Rev Med Chem. 2009 Aug;9(9):1084-101. (PMID: 19689405)
Int J Cancer. 2015 Oct 1;137(7):1519-27. (PMID: 24895240)
Oncol Lett. 2016 Jul;12(1):334-342. (PMID: 27347147)
Science. 2016 Apr 8;352(6282):175-80. (PMID: 27124451)
PeerJ. 2019 Feb 7;7:e6309. (PMID: 30746305)
J Natl Cancer Inst. 2001 Feb 21;93(4):309-14. (PMID: 11181778)
Radiat Oncol. 2009 Aug 06;4:29. (PMID: 19660100)
Mol Aspects Med. 2013 Apr-Jun;34(2-3):121-38. (PMID: 23506862)
FEBS Lett. 2004 Nov 19;577(3):439-45. (PMID: 15556624)
Medicine (Baltimore). 2018 Dec;97(51):e13551. (PMID: 30572455)
Jpn J Cancer Res. 2002 Oct;93(10):1123-8. (PMID: 12417042)
Environ Health Prev Med. 2018 Oct 20;23(1):50. (PMID: 30340457)
BMC Syst Biol. 2010 May 06;4:58. (PMID: 20459610)
J Clin Invest. 2016 Oct 3;126(10):3699-3707. (PMID: 27571407)
Technol Cancer Res Treat. 2013 Dec;12(6):525-35. (PMID: 23617290)
Nucleic Acids Res. 2001 May 1;29(9):e45. (PMID: 11328886)
Immunol Cell Biol. 2016 Jan;94(1):109-13. (PMID: 26150319)
Ann Surg. 2006 Mar;243(3):334-40. (PMID: 16495697)
Oncologist. 2004;9 Suppl 5:10-7. (PMID: 15591418)
Mol Phylogenet Evol. 1996 Feb;5(1):50-77. (PMID: 8673298)
Caspian J Intern Med. 2013 Spring;4(2):627-35. (PMID: 24009950)
J Cancer. 2016 Apr 26;7(7):817-22. (PMID: 27162540)
Nat Rev Clin Oncol. 2019 Jul;16(7):409-424. (PMID: 30796368)
Oncotarget. 2017 Jul 4;9(2):2728-2738. (PMID: 29416806)
Genomics. 1996 May 1;33(3):480-7. (PMID: 8661007)
J Gastroenterol Hepatol. 2013 Mar;28(3):401-5. (PMID: 23173651)
Cell Cycle. 2013 May 1;12(9):1371-84. (PMID: 23574725)
Oncol Lett. 2013 Jan;5(1):191-197. (PMID: 23255918)
Cancer. 2003 Feb 15;97(4):1015-24. (PMID: 12569601)
Cancer Res. 2000 Dec 15;60(24):7075-83. (PMID: 11156414)
المشرفين على المادة: 0 (Glucose Transporter Type 1)
0 (Hypoxia-Inducible Factor 1, alpha Subunit)
0 (SLC2A1 protein, human)
EC 4.2.1.1 (Carbonic Anhydrase IX)
تواريخ الأحداث: Date Created: 20210423 Date Completed: 20211108 Latest Revision: 20211108
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8062492
DOI: 10.1038/s41598-021-87897-2
PMID: 33888756
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-021-87897-2