دورية أكاديمية
أعرض في EDS

Key changes in chromatin mark mammalian epidermal differentiation and ageing.

التفاصيل البيبلوغرافية
العنوان: Key changes in chromatin mark mammalian epidermal differentiation and ageing.
المؤلفون: Dube CT; Epithelial Epigenetics and Development Laboratory, Skin Research Institute of Singapore, Singapore.; Faculty of Biology, Medicine and Health, School of Medical Sciences and Health, University of Manchester, Manchester, UK., Jahan FRS; Epithelial Epigenetics and Development Laboratory, Skin Research Institute of Singapore, Singapore., Lim CY; Epithelial Epigenetics and Development Laboratory, Skin Research Institute of Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
المصدر: Epigenetics [Epigenetics] 2022 Apr; Vol. 17 (4), pp. 444-459. Date of Electronic Publication: 2021 Apr 23.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101265293 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-2308 (Electronic) Linking ISSN: 15592294 NLM ISO Abbreviation: Epigenetics Subsets: MEDLINE
أسماء مطبوعة: Publication: 2015- : Philadelphia, PA : Taylor & Francis
Original Publication: Georgetown, Tex. : Landes Bioscience, c2006-
مواضيع طبية MeSH: Chromatin*/genetics , DNA Methylation*, Animals ; Cell Differentiation ; Epigenesis, Genetic ; Heterochromatin ; Histone Code ; Mammals ; Mice
مستخلص: Dynamic shifts in chromatin states occur during embryonic epidermal development to support diverse epigenetic pathways that regulate skin formation and differentiation. However, it is not known whether the epigenomes established during embryonic development are maintained into adulthood or how these epigenetic mechanisms may be altered upon physiological ageing of the tissue. Here, we systematically profiled the nuclear enrichment of five key histone modifications in young and aged mouse epidermis and identified distinct chromatin states that are tightly correlated with cellular differentiation, as well as chromatin alterations that accompanied epidermal ageing. Our data showed that histone modifications, which become differentially enriched in undifferentiated basal or differentiated suprabasal cells during embryonic development, retained their distinct cell-type specific enrichment patterns in both young and aged adult tissues. Specifically, high levels of H3K4me3, H4K20me1 and H4K16ac marked the proliferative basal cells, while differentiated suprabasal cells accumulated H3K27me3 and H4K20me3 heterochromatin with a concomitant deacetylation of H4K16. We further identified shifts in the chromatin in the aged basal epidermis, which exhibited markedly reduced levels of H4K16ac, absence of high H4K20me1 staining and increased cell-to-cell variability in total histone H3 and H4 content. Changes in the chromatin profiles in aged tissues paralleled the altered expression of their corresponding histone modifiers in the basal keratinocytes. These results thus reveal the key histone signatures of epidermal differentiation that are conserved from embryonic development to adult homoeostasis, and provide insights into the epigenetic pathways underlying physiological skin ageing.
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فهرسة مساهمة: Keywords: Histone modifications; ageing; chromatin; differentiation; epidermis
المشرفين على المادة: 0 (Chromatin)
0 (Heterochromatin)
تواريخ الأحداث: Date Created: 20210423 Date Completed: 20220407 Latest Revision: 20220603
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8993096
DOI: 10.1080/15592294.2021.1917812
PMID: 33890553
قاعدة البيانات: MEDLINE
الوصف
تدمد:1559-2308
DOI:10.1080/15592294.2021.1917812