دورية أكاديمية
Autoimmune pancytopenia after liver transplantation: A case report.
| العنوان: | Autoimmune pancytopenia after liver transplantation: A case report. |
|---|---|
| المؤلفون: | Barros MMO; Department of Hematology and Hemotherapy, Federal University of Sao Paulo, São Paulo, Brazil. Electronic address: melca.barros@unifesp.br., Ayoub FL; Department of Hematology and Hemotherapy, Federal University of Sao Paulo, São Paulo, Brazil., Lemos G; Department of Hematology and Hemotherapy, Federal University of Sao Paulo, São Paulo, Brazil., Brasileiro KC; Department of Hematology and Hemotherapy, Federal University of Sao Paulo, São Paulo, Brazil., da Silva Icibaci PB; Department of Hematology and Hemotherapy, Federal University of Sao Paulo, São Paulo, Brazil., Moritz E; Department of Hematology and Hemotherapy, Federal University of Sao Paulo, São Paulo, Brazil., Martins JO; Department of Hematology and Hemotherapy, Federal University of Sao Paulo, São Paulo, Brazil., Bub CB; Hospital Israelita Albert Einstein, Sao Paulo, São Paulo, Brazil., Chiba AK; Department of Hematology and Hemotherapy, Federal University of Sao Paulo, São Paulo, Brazil., Bordin JO; Department of Hematology and Hemotherapy, Federal University of Sao Paulo, São Paulo, Brazil. |
| المصدر: | Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis [Transfus Apher Sci] 2021 Aug; Vol. 60 (4), pp. 103136. Date of Electronic Publication: 2021 Apr 08. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Country of Publication: England NLM ID: 101095653 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-0502 (Print) Linking ISSN: 14730502 NLM ISO Abbreviation: Transfus Apher Sci |
| أسماء مطبوعة: | Original Publication: Oxford : Pergamon : Elsevier Science, c2001- |
| مواضيع طبية MeSH: | Autoimmune Diseases*/blood , Autoimmune Diseases*/etiology , Autoimmune Diseases*/therapy , Immunosuppression Therapy* , Liver Transplantation* , Pancytopenia*/blood , Pancytopenia*/etiology , Pancytopenia*/therapy, Autoantibodies/*blood , Prednisolone/*administration & dosage, Humans ; Male ; Middle Aged |
| مستخلص: | Introduction: Autoimmune hemolytic anemia (AIHA), immune thrombocytopenia (ITP), and autoimmune neutropenia (AIN) are reported in the literature after liver, intestinal, heart, pancreas, and kidney transplants. We report a case of autoimmune pancytopenia (AIHA, AIN and ITP) 9 years after liver transplantation with confirmed erythrocyte and neutrophil auto-antibodies. Case Report: A 49 years old man was admitted to our hospital presented with dysentery and fever, with history of liver transplantation in 2008. Laboratory evaluation demonstrated hemoglobin: 7.2 g/dL, granulocytes: 0.10 × 10 9 /L and platelets: 15 × 10 9 /mm³; indirect bilirubin: 3.62 mg/dL; lactate dehydrogenase: 603 U/L. Direct antiglobulin test revealed a monospecific anti-IgG plus C3 and the acid eluate was reactive to all panel red cells, consistent with an AIHA. Granulocyte immunofluorescence test (GIFT) and agglutination test (GAT) were reactive for granulocytes. Test with Luminex technology for human neutrophil antigen (HNA) antibody detection was strong reactive with beads expressing HNA-1a, -1b, -1c, -2, -4a and -5a antigens. HNA genotyping revealed the presence of the corresponding antigens, confirming the autoantibodies. Test with Luminex technology for human leucocyte antigen (HLA) antibody detection was negative. Monoclonal antibody immobilization of platelet antigens (MAIPA) assay was negative. Viral causes were excluded. The condition was compatible with clinical onset of autoimmune pancytopenia. Prednisone was administered at an initial dose of 1 mg/kg/day and immunosuppressive therapy was adjusted. This treatment resulted in rapid resolution of pancytopenia. Conclusion: Combined autoimmune pancytopenia (AIHA, AIN and ITP) is a rare condition that may occur after liver transplantation. Early recognition of this phenomenon permits appropriate treatment. (Copyright © 2021 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Autoimmune hemolytic anemia (AIHA); Autoimmune neutropenia (AIN); Case report; GIFT; Immune thrombocytopenia (ITP); MAIPA |
| المشرفين على المادة: | 0 (Autoantibodies) 9PHQ9Y1OLM (Prednisolone) |
| تواريخ الأحداث: | Date Created: 20210425 Date Completed: 20220112 Latest Revision: 20220112 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.transci.2021.103136 |
| PMID: | 33895070 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1473-0502 |
|---|---|
| DOI: | 10.1016/j.transci.2021.103136 |