دورية أكاديمية
Oxidation-Sensitive Core-Multishell Nanocarriers for the Controlled Delivery of Hydrophobic Drugs.
| العنوان: | Oxidation-Sensitive Core-Multishell Nanocarriers for the Controlled Delivery of Hydrophobic Drugs. |
|---|---|
| المؤلفون: | Rajes K; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3 and Arnimalle 22, 14195 Berlin, Germany., Walker KA; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3 and Arnimalle 22, 14195 Berlin, Germany., Hadam S; Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitaetsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany., Zabihi F; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3 and Arnimalle 22, 14195 Berlin, Germany.; Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitaetsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany., Ibrahim-Bacha J; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3 and Arnimalle 22, 14195 Berlin, Germany., Germer G; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3 and Arnimalle 22, 14195 Berlin, Germany., Patoka P; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3 and Arnimalle 22, 14195 Berlin, Germany., Wassermann B; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3 and Arnimalle 22, 14195 Berlin, Germany., Rancan F; Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitaetsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany., Rühl E; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3 and Arnimalle 22, 14195 Berlin, Germany., Vogt A; Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitaetsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany., Haag R; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3 and Arnimalle 22, 14195 Berlin, Germany. |
| المصدر: | ACS biomaterials science & engineering [ACS Biomater Sci Eng] 2021 Jun 14; Vol. 7 (6), pp. 2485-2495. Date of Electronic Publication: 2021 Apr 27. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101654670 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-9878 (Electronic) Linking ISSN: 23739878 NLM ISO Abbreviation: ACS Biomater Sci Eng Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : American Chemical Society, [2015]- |
| مواضيع طبية MeSH: | Drug Carriers* , Nanoparticles*, Dexamethasone ; Drug Delivery Systems ; Humans ; Oxidation-Reduction |
| مستخلص: | A synthetic route for oxidation-sensitive core-multishell (osCMS) nanocarriers was established, and their drug loading and release properties were analyzed based on their structural variations. The nanocarriers showed a drug loading of 0.3-3 wt % for the anti-inflammatory drugs rapamycin and dexamethasone and the photosensitizer meso -tetra-hydroxyphenyl-porphyrin ( m THPP). Oxidative processes of the nanocarriers were probed in vitro by hydrogen peroxide, and the degradation products were identified by infrared spectroscopy supported by ab initio calculations, yielding mechanistic details on the chemical changes occurring in redox-sensitive nanocarriers. Oxidation-triggered drug release of the model drug Nile Red measured and assessed by time-dependent fluorescence spectroscopy showed a release of up to 80% within 24 h. The drug delivery capacity of the new osCMS nanocarriers was tested in ex vivo human skin with and without pretreatments to induce local oxidative stress. It was found that the delivery of m THPP was selectively enhanced in skin under oxidative stress. The number and position of the thioether groups influenced the physicochemical as well as drug delivery properties of the carriers. |
| فهرسة مساهمة: | Keywords: AFM-IR; CMS nanocarriers; Nile Red; anti-inflammatory drugs; dexamethasone; mTHPP; oxidation; rapamycin; redox; skin penetration; stimuli-triggered; thioether |
| المشرفين على المادة: | 0 (Drug Carriers) 7S5I7G3JQL (Dexamethasone) |
| تواريخ الأحداث: | Date Created: 20210427 Date Completed: 20210621 Latest Revision: 20210621 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1021/acsbiomaterials.0c01771 |
| PMID: | 33905661 |
| قاعدة البيانات: | MEDLINE |
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