دورية أكاديمية
Variants at the ASIP locus contribute to coat color darkening in Nellore cattle.
| العنوان: | Variants at the ASIP locus contribute to coat color darkening in Nellore cattle. |
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| المؤلفون: | Trigo BB; School of Veterinary Medicine, Araçatuba, Department of Production and Animal Health, São Paulo State University (Unesp), Araçatuba, SP, Brazil.; International Atomic Energy Agency (IAEA) Collaborating Centre On Animal Genomics and Bioinformatics, Araçatuba, SP, Brazil., Utsunomiya ATH; International Atomic Energy Agency (IAEA) Collaborating Centre On Animal Genomics and Bioinformatics, Araçatuba, SP, Brazil.; AgroPartners Consulting, R. Floriano Peixoto, 120-Sala 43a-Centro, Araçatuba, SP, 16010-220, Brazil., Fortunato AAAD; School of Veterinary Medicine, Araçatuba, Department of Production and Animal Health, São Paulo State University (Unesp), Araçatuba, SP, Brazil.; International Atomic Energy Agency (IAEA) Collaborating Centre On Animal Genomics and Bioinformatics, Araçatuba, SP, Brazil.; Personal-PEC, R. Sebastião Lima, 1336-Centro, Campo Grande, MS, 79004-600, Brazil., Milanesi M; School of Veterinary Medicine, Araçatuba, Department of Production and Animal Health, São Paulo State University (Unesp), Araçatuba, SP, Brazil.; International Atomic Energy Agency (IAEA) Collaborating Centre On Animal Genomics and Bioinformatics, Araçatuba, SP, Brazil.; AgroPartners Consulting, R. Floriano Peixoto, 120-Sala 43a-Centro, Araçatuba, SP, 16010-220, Brazil., Torrecilha RBP; International Atomic Energy Agency (IAEA) Collaborating Centre On Animal Genomics and Bioinformatics, Araçatuba, SP, Brazil.; AgroPartners Consulting, R. Floriano Peixoto, 120-Sala 43a-Centro, Araçatuba, SP, 16010-220, Brazil., Lamb H; Centre for Animal Science, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Brisbane, Australia., Nguyen L; Centre for Animal Science, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Brisbane, Australia., Ross EM; Centre for Animal Science, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Brisbane, Australia., Hayes B; Centre for Animal Science, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Brisbane, Australia., Padula RCM; Centro Universitário Católico Salesiano, Araçatuba, SP, Brazil., Sussai TS; Centro Universitário Católico Salesiano, Araçatuba, SP, Brazil., Zavarez LB; International Atomic Energy Agency (IAEA) Collaborating Centre On Animal Genomics and Bioinformatics, Araçatuba, SP, Brazil., Cipriano RS; Centro Universitário Católico Salesiano, Araçatuba, SP, Brazil., Caminhas MMT; School of Veterinary Medicine, Araçatuba, Department of Production and Animal Health, São Paulo State University (Unesp), Araçatuba, SP, Brazil., Lopes FL; School of Veterinary Medicine, Araçatuba, Department of Production and Animal Health, São Paulo State University (Unesp), Araçatuba, SP, Brazil., Pelle C; CRV Lagoa, Sertãozinho, SP, Brazil., Leeb T; Institute of Genetics, Vetsuisse-Faculty, University of Bern, Bremgartenstrasse 109A, 3012, Bern, Switzerland.; Dermfocus, University of Bern, Bremgartenstrasse 109A, 3012, Bern, Switzerland., Bannasch D; Institute of Genetics, Vetsuisse-Faculty, University of Bern, Bremgartenstrasse 109A, 3012, Bern, Switzerland.; Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA., Bickhart D; Dairy Forage Research Center, USDA-ARS, 1925 Linden Drive, Madison, WI, 53706, USA., Smith TPL; US. Meat Animal Research Center, USDA-ARS, 844 Road 313, Clay Center, NE, 68933, USA., Sonstegard TS; Recombinetics Inc., St. Paul, MN, USA., Garcia JF; School of Veterinary Medicine, Araçatuba, Department of Production and Animal Health, São Paulo State University (Unesp), Araçatuba, SP, Brazil.; International Atomic Energy Agency (IAEA) Collaborating Centre On Animal Genomics and Bioinformatics, Araçatuba, SP, Brazil.; AgroPartners Consulting, R. Floriano Peixoto, 120-Sala 43a-Centro, Araçatuba, SP, 16010-220, Brazil.; School of Agriculture and Veterinarian Sciences, Jaboticabal, Department of Preventive Veterinary Medicine and Animal Reproduction, São Paulo State University (Unesp), Jaboticabal, SP, Brazil., Utsunomiya YT; School of Veterinary Medicine, Araçatuba, Department of Production and Animal Health, São Paulo State University (Unesp), Araçatuba, SP, Brazil. ytutsunomiya@gmail.com.; International Atomic Energy Agency (IAEA) Collaborating Centre On Animal Genomics and Bioinformatics, Araçatuba, SP, Brazil. ytutsunomiya@gmail.com.; AgroPartners Consulting, R. Floriano Peixoto, 120-Sala 43a-Centro, Araçatuba, SP, 16010-220, Brazil. ytutsunomiya@gmail.com. |
| المصدر: | Genetics, selection, evolution : GSE [Genet Sel Evol] 2021 Apr 28; Vol. 53 (1), pp. 40. Date of Electronic Publication: 2021 Apr 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: France NLM ID: 9114088 Publication Model: Electronic Cited Medium: Internet ISSN: 1297-9686 (Electronic) Linking ISSN: 0999193X NLM ISO Abbreviation: Genet Sel Evol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : BioMed Central Original Publication: Paris : Elsevier, c1989- |
| مواضيع طبية MeSH: | Polymorphism, Genetic*, Agouti Signaling Protein/*genetics , Cattle/*genetics , Pigmentation/*genetics, Animal Fur/metabolism ; Animals ; DNA Transposable Elements ; INDEL Mutation ; Melanins/genetics ; Melanins/metabolism |
| مستخلص: | Background: Nellore cattle (Bos indicus) are well-known for their adaptation to warm and humid environments. Hair length and coat color may impact heat tolerance. The Nellore breed has been strongly selected for white coat, but bulls generally exhibit darker hair ranging from light grey to black on the head, neck, hump, and knees. Given the potential contribution of coat color variation to the adaptation of cattle populations to tropical and sub-tropical environments, our aim was to map positional and functional candidate genetic variants associated with darkness of hair coat (DHC) in Nellore bulls. Results: We performed a genome-wide association study (GWAS) for DHC using data from 432 Nellore bulls that were genotyped for more than 777 k single nucleotide polymorphism (SNP) markers. A single major association signal was detected in the vicinity of the agouti signaling protein gene (ASIP). The analysis of whole-genome sequence (WGS) data from 21 bulls revealed functional variants that are associated with DHC, including a structural rearrangement involving ASIP (ASIP-SV1). We further characterized this structural variant using Oxford Nanopore sequencing data from 13 Australian Brahman heifers, which share ancestry with Nellore cattle; we found that this variant originates from a 1155-bp deletion followed by an insertion of a transposable element of more than 150 bp that may impact the recruitment of ASIP non-coding exons. Conclusions: Our results indicate that the variant ASIP sequence causes darker coat pigmentation on specific parts of the body, most likely through a decreased expression of ASIP and consequently an increased production of eumelanin. |
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| معلومات مُعتمدة: | 2010/52030-2 Sao Paulo Research Foundation (FAPESP); 2016/05787-7 Sao Paulo Research Foundation (FAPESP); 560922/2010-8 National Council for Scientific and Technological Development (CNPq); 483590/2010-0 National Council for Scientific and Technological Development (CNPq); B.STU.2001 Meat and Livestock Australia; P.PSH.0833 Meat and Livestock Australia; L.GEN.1808 Meat and Livestock Australia |
| المشرفين على المادة: | 0 (Agouti Signaling Protein) 0 (DNA Transposable Elements) 0 (Melanins) 12627-86-0 (eumelanin) |
| تواريخ الأحداث: | Date Created: 20210429 Date Completed: 20210803 Latest Revision: 20210803 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC8082809 |
| DOI: | 10.1186/s12711-021-00633-2 |
| PMID: | 33910501 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1297-9686 |
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| DOI: | 10.1186/s12711-021-00633-2 |