دورية أكاديمية
أعرض في EDS

Incidence of advanced opportunistic infection and its predictors among HIV infected children at Debre Tabor referral Hospital and University of Gondar Compressive specialized hospitals, Northwest Ethiopia, 2020: A multicenter retrospective follow-up study.

التفاصيل البيبلوغرافية
العنوان: Incidence of advanced opportunistic infection and its predictors among HIV infected children at Debre Tabor referral Hospital and University of Gondar Compressive specialized hospitals, Northwest Ethiopia, 2020: A multicenter retrospective follow-up study.
المؤلفون: Chanie ES; Department of Pediatrics and Child Health Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Bayih WA; Department of Pediatrics and Child Health Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Birhan BM; Department of Pediatrics and Child Health Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Belay DM; Department of Pediatrics and Child Health Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Asmare G; Department of Pediatrics and Child Health Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Tiruneh T; Department of Medical Laboratory, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Aynalem YAA; Department of Pediatrics and Child Health Nursing, College of Health Sciences, Debre Birhan University, Debre Birhan, Ethiopia., Abat BB; Department of Nursing, College of Health Sciences, Woldia University, Woldia, Ethiopia., Asnakew S; Department Psychiatric, School of Medicine, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Mekie M; Department Midwifery, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Yitbarek GY; Department of Biomedical, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., GebreEyesus FA; Department Nursing, College of Health Sciences, Wolkite University, Wolkite, Ethiopia.
المصدر: Heliyon [Heliyon] 2021 Apr 09; Vol. 7 (4), pp. e06745. Date of Electronic Publication: 2021 Apr 09 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : Elsevier Ltd, [2015]-
مستخلص: Background: This study is aimed to assess the incidence of advanced opportunistic infections (OIs) and its predictors among Human Immunodeficiency Virus (HIV) infected children at Debre Tabor referral Hospital and University of Gondar Compressive specialized Hospitals, Northwest Ethiopia, 2020.
Methods: A retrospective follow-up study was conducted from June 1, 2010, to May 30, 2020. A total of 349 children under the age of 15 who had received Anti-Retroviral Therapy (ART) were included in the study. Data were entered into Epi info version 7.2 and then exported to Stata 14.0 for analysis. Kaplan Meier curve and Log-rank test were used to determine the median survival time and the discrepancy of different categorical variables. The Cox regression model was used to identify the predictors of advanced opportunistic infections. The Adjusted hazard ratio (AHR) at 95% confidence interval (CI) was used to declare statistical significance.
Result: The incidence rate of advanced opportunistic infection was 5.53 per 100 (95% CI: 4.7, 6.9) Person per year observation (PYO). The median survival time was 113 months and the total follow-up periods were yielding 18882 months. Children presenting with treatment failure, Cotrimoxazole Preventive Therapy (CPT) non-user, low hemoglobin level (<10 mg/dl), and poor/fair level of adherence to ART were less free survival time as compared to their counterparts for advanced opportunistic infections.
Conclusion: In this study, the median of advanced OIs free survival time was found to be low and the incidence rate was found to be high. The incidence advanced OIs was associated with anemia, treatment failure, and poor/fair level of adherence, cotrimoxazole preventive therapy non-users. Further research should conduct to evaluate and to improve the quality of care in the study area.
Competing Interests: The authors declare no conflict of interest.
(© 2021 The Author(s).)
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فهرسة مساهمة: Keywords: Advanced; Ethiopia; Opportunistic infection; Predictors; Time to develop
تواريخ الأحداث: Date Created: 20210429 Latest Revision: 20220422
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8063747
DOI: 10.1016/j.heliyon.2021.e06745
PMID: 33912717
قاعدة البيانات: MEDLINE
الوصف
تدمد:2405-8440
DOI:10.1016/j.heliyon.2021.e06745