دورية أكاديمية
Innate allorecognition in transplantation.
| العنوان: | Innate allorecognition in transplantation. |
|---|---|
| المؤلفون: | Abou-Daya KI; Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania., Oberbarnscheidt MH; Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: mho6@pitt.edu. |
| المصدر: | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation [J Heart Lung Transplant] 2021 Jul; Vol. 40 (7), pp. 557-561. Date of Electronic Publication: 2021 Mar 29. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 9102703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3117 (Electronic) Linking ISSN: 10532498 NLM ISO Abbreviation: J Heart Lung Transplant Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1999- : New York, NY : Elsevier Original Publication: St. Louis, Mo. : Mosby-Year Book, Inc., c1991- |
| مواضيع طبية MeSH: | Organ Transplantation*, Graft Rejection/*immunology , Immunity, Innate/*immunology, Humans ; Transplantation, Homologous |
| مستخلص: | Successful allogeneic transplantation has been made possible by suppressing activation of the adaptive immune system. Current immunosuppressive therapy prevents rejection by targeting T and B cells. Despite this effective treatment, it is the innate immune system, which includes dendritic cells, monocytes, natural killer cells, that is responsible for the initiation of the adaptive immune response. Recent work has described that the innate immune system is capable of recognizing allogeneic nonself and some of the mechanisms of innate allorecognition have been uncovered. Better understanding of the role of the innate immune system in initiation and maintenance of the allo-immune response has potential to lead to better treatment strategies for transplant patients, prolonging allograft survival. Here, we review advances in our understanding of innate allorecognition in transplantation. (Copyright © 2021 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.) |
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| معلومات مُعتمدة: | R01 AI145881 United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: allorecognition; dendritic cell; innate immunity; monocyte; monocyte memory; transplantation |
| تواريخ الأحداث: | Date Created: 20210507 Date Completed: 20220131 Latest Revision: 20220716 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC8238827 |
| DOI: | 10.1016/j.healun.2021.03.018 |
| PMID: | 33958265 |
| قاعدة البيانات: | MEDLINE |
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