دورية أكاديمية
Evaluation of antiplasmodial activity and cytotoxicity assays of amino acids functionalized magnetite nanoparticles: Hyperthermia and flow cytometry applications.
| العنوان: | Evaluation of antiplasmodial activity and cytotoxicity assays of amino acids functionalized magnetite nanoparticles: Hyperthermia and flow cytometry applications. |
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| المؤلفون: | Rodriguez AFR; Laboratory of Nanobiotechnology, Federal University of Acre, Rio Branco, AC 69920-900, Brazil. Electronic address: anselmo.rodriguez@ufac.br., Dos Santos CC; Laboratory of Magnetic Materials and Colloids, Department of Physical Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP 14801-970, Brazil., Lüdtke-Buzug K; Institute of Medical Engineering, University of Lubeck, Lübeck, Germany., Bakenecker AC; Institute of Medical Engineering, University of Lubeck, Lübeck, Germany., Chaves YO; Diagnostic Laboratory and Control of Infectious Diseases in The Amazon - DCDIA Institute Leonidas e Maria Deane, Foundation Oswaldo Cruz, street Teresina 476 Adrianópolis, 69057-070 Manaus, AM, Brazil., Mariúba LAM; Diagnostic Laboratory and Control of Infectious Diseases in The Amazon - DCDIA Institute Leonidas e Maria Deane, Foundation Oswaldo Cruz, street Teresina 476 Adrianópolis, 69057-070 Manaus, AM, Brazil., Brandt JV; Laboratory of Magnetic Materials and Colloids, Department of Physical Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP 14801-970, Brazil., Amantea BE; Laboratory of Magnetic Materials and Colloids, Department of Physical Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP 14801-970, Brazil., de Santana RC; Materials Physics Group, Physics Institute, Federal University of Goiás, Goiânia 74690-900, GO, Brazil., Marques RFC; Laboratory of Magnetic Materials and Colloids, Department of Physical Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP 14801-970, Brazil., Jafelicci M Jr; Laboratory of Magnetic Materials and Colloids, Department of Physical Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP 14801-970, Brazil., Morales MA; Federal University of Rio Grande do Norte, Department of Theoretical and Experimental Physics, Natal 59078-970, RN, Brazil. |
| المصدر: | Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2021 Jun; Vol. 125, pp. 112097. Date of Electronic Publication: 2021 Apr 18. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101484109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-0191 (Electronic) Linking ISSN: 09284931 NLM ISO Abbreviation: Mater Sci Eng C Mater Biol Appl Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier |
| مواضيع طبية MeSH: | Antimalarials* , Magnetite Nanoparticles*, Amino Acids ; Flow Cytometry ; Humans ; Hyperthermia ; Spectroscopy, Fourier Transform Infrared |
| مستخلص: | We report the synthesis of magnetite nanoparticles (MNP) and their functionalization with glycine (MNPGly), β-alanine (MNPAla), L-phenylalanine (MNPPhAla), D-(-)-α-phenylglycine (MNPPhGly) amino acids. The functionalized nanoparticles were characterized by Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), electron paramagnetic resonance (EPR), vibrating sample magnetometry (VSM), Mössbauer spectroscopy (MS), magnetic hyperthermia (MH), dynamic light scattering and zeta potential. The functionalized nanoparticles had isoelectric points (IEP) at pH ≃ 4.4, 5.8, 5.9 and 6.8 for samples MNPGly, MNPAla, MNPPhGly and MNPPhAla, respectively, while pure magnetite had an IEP at pH 5.6. In the MH experiments, the samples showed specific absorption rate (SAR) of 64, 71, 74, 81 and 66 W/g for MNP, MNPGly, MNPAla, MNPPhGly, and MNPPhAla, respectively. We used a flow cytometric technique to determine the cellular magnetic nanoparticles plus amino acids content. Magnetic fractionation and characterization of Resovist® magnetic nanoparticles were performed for applications in magnetic particle imaging (MPI). We have also studied the antiproliferative and antiparasitic effects of functionalized MNPs. Overall, the data showed that the functionalized nanoparticles have great potential for using as environmental, antitumor, antiparasitic agents and clinical applications. (Copyright © 2021 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Amino acids; Flow cytometry; Magnetic hyperthermia; Nanoparticles; Nanotoxicology |
| المشرفين على المادة: | 0 (Amino Acids) 0 (Antimalarials) 0 (Magnetite Nanoparticles) |
| تواريخ الأحداث: | Date Created: 20210509 Date Completed: 20210519 Latest Revision: 20210519 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.msec.2021.112097 |
| PMID: | 33965107 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-0191 |
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| DOI: | 10.1016/j.msec.2021.112097 |