دورية أكاديمية
أعرض في EDS

Assessment of Serum Vitamin B 12 and Folate Levels and Macrocytosis in Patients with Type 2 Diabetes Mellitus on Metformin Attending Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: A Cross-Sectional Study.

التفاصيل البيبلوغرافية
العنوان: Assessment of Serum Vitamin B 12 and Folate Levels and Macrocytosis in Patients with Type 2 Diabetes Mellitus on Metformin Attending Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: A Cross-Sectional Study.
المؤلفون: Wale Tesega W; Department of Biomedical Sciences, School of Medicine, College of Health Sciences, Arbaminch University, Arba Minch, Ethiopia., Genet S; Department of Medical Biochemistry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia., Natesan G; Department of Medical Biochemistry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia., Tarekegn G; Department of Medical Biochemistry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia., Girma F; National Reference Laboratory for Immunohematology, Ethiopian Public Health Institute, Addis Ababa, Ethiopia., Chalchisa D; National Reference Laboratory for Immunohematology, Ethiopian Public Health Institute, Addis Ababa, Ethiopia., Belay Y; National Reference Laboratory for Immunohematology, Ethiopian Public Health Institute, Addis Ababa, Ethiopia., Geto Z; Department of Biomedical Science, College of Medicine and Health Science, Wollo University, Dessie, Ethiopia., Asmamaw Dejenie T; Department of Biochemistry, School of Medicine, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia.
المصدر: Diabetes, metabolic syndrome and obesity : targets and therapy [Diabetes Metab Syndr Obes] 2021 May 03; Vol. 14, pp. 2011-2018. Date of Electronic Publication: 2021 May 03 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Dove Medical Press Country of Publication: New Zealand NLM ID: 101515585 Publication Model: eCollection Cited Medium: Print ISSN: 1178-7007 (Print) Linking ISSN: 11787007 NLM ISO Abbreviation: Diabetes Metab Syndr Obes Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Auckland, N.Z.] : Dove Medical Press, c2008-
مستخلص: Background: Metformin is the first-line drug in the treatment of type 2 diabetes mellitus. Monitoring vitamin B 12 deficiency associated with long-term and high-dose therapy is not a common practice in many clinical settings in Ethiopia.
Objective: The study aimed to measure levels of serum vitamin B 12 and folate and to assess the macrocytic status of type 2 diabetes mellitus patients on metformin.
Methods: A cross-sectional study was conducted on 80 type 2 diabetes mellitus patients who had been on metformin for 5 months or more at the diabetic clinic of Tikur Anbessa Specialized Teaching Hospital. Serum vitamin B 12 and folate levels were quantified by chemiluminescent immunoassays. Mean corpuscular volume was determined by complete blood count. Differences in vitamin B 12 and folate levels and mean corpuscular volume between different groups were assessed using Kruskal-Wallis H and Mann-Whitney U tests.
Results: Vitamin B 12 and folate deficiency were documented in 5% and 23.8% of participants, respectively, and 6.2% of patients were macrocytic. Levels of vitamin B 12 and folate in patients who had been on metformin >1,500 mg/day ≥4 years were significantly lower those who had been on metformin 1,000-1,500 mg/day and <1,000 mg/day <4 years, respectively.
Conclusion: Low serum vitamin B 12 and folate levels and macrocytosis were found to be associated with prolonged metformin treatment.
Competing Interests: The authors declare that they have no conflicts of interest for this work.
(© 2021 Wale Tesega et al.)
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فهرسة مساهمة: Keywords: folate; macrocytosis; metformin; type 2 diabetes mellitus; vitamin B12
تواريخ الأحداث: Date Created: 20210512 Latest Revision: 20220422
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8106448
DOI: 10.2147/DMSO.S306433
PMID: 33976561
قاعدة البيانات: MEDLINE
الوصف
تدمد:1178-7007
DOI:10.2147/DMSO.S306433