دورية أكاديمية
أعرض في EDS

Heterogeneous subpopulations of adventitial progenitor cells regulate vascular homeostasis and pathological vascular remodelling.

التفاصيل البيبلوغرافية
العنوان: Heterogeneous subpopulations of adventitial progenitor cells regulate vascular homeostasis and pathological vascular remodelling.
المؤلفون: Jolly AJ; Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Anschutz Medical Campus, 12700 East 19th Avenue, Aurora, CO 80045, USA., Lu S; Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Anschutz Medical Campus, 12700 East 19th Avenue, Aurora, CO 80045, USA., Strand KA; Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Anschutz Medical Campus, 12700 East 19th Avenue, Aurora, CO 80045, USA., Dubner AM; Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Anschutz Medical Campus, 12700 East 19th Avenue, Aurora, CO 80045, USA., Mutryn MF; Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Anschutz Medical Campus, 12700 East 19th Avenue, Aurora, CO 80045, USA., Nemenoff RA; Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Anschutz Medical Campus, 12700 East 19th Avenue, Aurora, CO 80045, USA.; School of Medicine, Consortium for Fibrosis Research and Translation, University of Colorado Anschutz Medical Campus, 12700 East 19th Avenue, Aurora, CO 80045, USA., Majesky MW; Center for Developmental Biology & Regenerative Medicine, Seattle Children's Research Center, 1900 9th Avenue, Seattle, WA 98101, USA.; Department of Pediatrics and Pathology, University of Washington, 1900 9th Avenue, Seattle, WA 98195, USA., Moulton KS; Department of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, 12700 East 19th Avenue, Aurora, CO 80045, USA., Weiser-Evans MCM; Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Anschutz Medical Campus, 12700 East 19th Avenue, Aurora, CO 80045, USA.; School of Medicine, Consortium for Fibrosis Research and Translation, University of Colorado Anschutz Medical Campus, 12700 East 19th Avenue, Aurora, CO 80045, USA.; Cardiovascular Pulmonary Research Program, University of Colorado Anschutz Medical Campus, 12700 East 19th Avenue, Aurora, CO 80045, USA.
المصدر: Cardiovascular research [Cardiovasc Res] 2022 May 06; Vol. 118 (6), pp. 1452-1465.
نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Oxford Journals Country of Publication: England NLM ID: 0077427 Publication Model: Print Cited Medium: Internet ISSN: 1755-3245 (Electronic) Linking ISSN: 00086363 NLM ISO Abbreviation: Cardiovasc Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 2008- : Oxford : Oxford Journals
Original Publication: London, British Medical Assn.
مواضيع طبية MeSH: Atherosclerosis*/metabolism , Spinocerebellar Ataxias*/metabolism , Spinocerebellar Ataxias*/pathology, Animals ; Cell Differentiation/genetics ; Endothelial Cells/pathology ; Fibrosis ; Homeostasis ; Mice ; Myocytes, Smooth Muscle/metabolism ; Neointima/metabolism ; Stem Cells/metabolism ; Vascular Remodeling
مستخلص: Cardiovascular diseases are characterized by chronic vascular dysfunction and provoke pathological remodelling events, such as neointima formation, atherosclerotic lesion development, and adventitial fibrosis. While lineage-tracing studies have shown that phenotypically modulated smooth muscle cells (SMCs) are the major cellular component of neointimal lesions, the cellular origins and microenvironmental signalling mechanisms that underlie remodelling along the adventitial vascular layer are not fully understood. However, a growing body of evidence supports a unique population of adventitial lineage-restricted progenitor cells expressing the stem cell marker, stem cell antigen-1 (Sca1; AdvSca1 cells) as important effectors of adventitial remodelling and suggests that they are at least partially responsible for subsequent pathological changes that occur in the media and intima. AdvSca1 cells are being studied in murine models of atherosclerosis, perivascular fibrosis, and neointima formation in response to acute vascular injury. Depending on the experimental conditions, AdvSca1 cells exhibit the capacity to differentiate into SMCs, endothelial cells, chondrocytes, adipocytes, and pro-remodelling cells, such as myofibroblasts and macrophages. These data indicate that AdvSca1 cells may be a targetable cell population to influence the outcomes of pathologic vascular remodelling. Important questions remain regarding the origins of AdvSca1 cells and the essential signalling mechanisms and microenvironmental factors that regulate both maintenance of their stem-like, progenitor phenotype and their differentiation into lineage-specified cell types. Adding complexity to the story, recent data indicate that the collective population of adventitial progenitor cells is likely composed of several smaller, lineage-restricted subpopulations, which are not fully defined by their transcriptomic profile and differentiation capabilities. The aim of this review is to outline the heterogeneity of Sca1+ adventitial progenitor cells, summarize their role in vascular homeostasis and remodelling, and comment on their translational relevance in humans.
(Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com.)
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معلومات مُعتمدة: T32 GM008497 United States GM NIGMS NIH HHS; F31 HL147393 United States HL NHLBI NIH HHS; T32 GM007635 United States GM NIGMS NIH HHS; R01 HL151331 United States HL NHLBI NIH HHS; T32 HL007822 United States HL NHLBI NIH HHS; R01 HL121877 United States HL NHLBI NIH HHS; R01 HL123616 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: AdvSca1 cells; Atherosclerosis; Neointima formation; Pathological vascular remodelling; Vascular fibrosis
تواريخ الأحداث: Date Created: 20210514 Date Completed: 20220510 Latest Revision: 20220716
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9074982
DOI: 10.1093/cvr/cvab174
PMID: 33989378
قاعدة البيانات: MEDLINE
الوصف
تدمد:1755-3245
DOI:10.1093/cvr/cvab174