دورية أكاديمية
Does Intravenous Ondansetron Affect the Intestinal Motility Pattern in Healthy Donkeys (Equus asinus)?
| العنوان: | Does Intravenous Ondansetron Affect the Intestinal Motility Pattern in Healthy Donkeys (Equus asinus)? |
|---|---|
| المؤلفون: | Farag AMM; Department of Internal Medicine, Infectious and Fish Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt., Ibrahim HMM; Department of Internal Medicine, Infectious and Fish Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt. Electronic address: hussam-habosha@mans.edu.eg. |
| المصدر: | Journal of equine veterinary science [J Equine Vet Sci] 2021 Jun; Vol. 101, pp. 103427. Date of Electronic Publication: 2021 Feb 25. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial, Veterinary |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 8216840 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0737-0806 (Print) Linking ISSN: 07370806 NLM ISO Abbreviation: J Equine Vet Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2003- : New York : Elsevier Original Publication: [Wildomar, CA : William E. Jones, c1981- |
| مواضيع طبية MeSH: | Equidae* , Ondansetron*/pharmacology, Animals ; Cross-Over Studies ; Female ; Gastrointestinal Motility ; Horses ; Infusions, Intravenous/veterinary ; Male |
| مستخلص: | The current study was undertaken to investigate the effect of intravenous administration of ondansetron on the small and large intestinal motility in donkeys (Equus asinus) using non-invasive transabdominal ultrasonography. The current prospective, randomized, placebo-controlled, crossover study was conducted on thirty healthy donkeys (15 males and 15 females). The selected donkeys underwent two trials; the first was performed by intravenous administration of saline solution as a placebo, while the second was carried out by intravenous administration of ondansetron hydrochloride. The contractility of selected portions of both the small intestine (duodenum and jejunum) and the large intestine (left colon, right colon, and cecum) was counted over a period of 3 minutes before administration (zero time) and at 15, 30, 60, 90, 120, 180, and 240 minutes after administration. The results of this study showed that ondansetron significantly altered the small and large intestinal contractility compared to normal saline. Intravenous administration of ondansetron induced a significant decrease in the duodenal, jejunal and cecal contractility compared to placebo at 30, 60, 90, and 120 minutes after administration. Likewise, ondansetron induced a significant decrease in the left colon and right colon contractility when compared with placebo at 30, 60, 90, 120, and 180 minutes following administration. Ondansetron can be used as a highly specific and selective serotonin 5-HT (Copyright © 2021. Published by Elsevier Inc.) |
| فهرسة مساهمة: | Keywords: Donkeys; Intestinal Motility Pattern; Ondansetron; Transabdominal ultrasonography |
| المشرفين على المادة: | 4AF302ESOS (Ondansetron) |
| تواريخ الأحداث: | Date Created: 20210517 Date Completed: 20210709 Latest Revision: 20220531 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jevs.2021.103427 |
| PMID: | 33993949 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0737-0806 |
|---|---|
| DOI: | 10.1016/j.jevs.2021.103427 |