دورية أكاديمية
أعرض في EDS

Intracystic Glucose Levels Appear Useful for Diagnosis of Pancreatic Cystic Lesions: A Systematic Review and Meta-Analysis.

التفاصيل البيبلوغرافية
العنوان: Intracystic Glucose Levels Appear Useful for Diagnosis of Pancreatic Cystic Lesions: A Systematic Review and Meta-Analysis.
المؤلفون: Guzmán-Calderón E; Gastroenterology Unit of Hospital Nacional Edgardo Rebagliati Martins, Av. Edgardo Rebagliati s/n, Jesús María, Lima, Peru. edson_guzman@hotmail.com.; Universidad Peruana de Ciencias Aplicadas (UPC), Lima, Peru. edson_guzman@hotmail.com.; Gastroenterology Unit of Angloamericana Clinic, Lima, Peru. edson_guzman@hotmail.com., Md BM; Gastroenterology Unit Oh Hospital General Universitario de Alicante, Alicante, Spain., Casellas JA; Gastroenterology Unit Oh Hospital General Universitario de Alicante, Alicante, Spain., Aparicio JR; Gastroenterology Unit Oh Hospital General Universitario de Alicante, Alicante, Spain.
المصدر: Digestive diseases and sciences [Dig Dis Sci] 2022 Jun; Vol. 67 (6), pp. 2562-2570. Date of Electronic Publication: 2021 May 19.
نوع المنشور: Journal Article; Meta-Analysis; Systematic Review
اللغة: English
بيانات الدورية: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 7902782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2568 (Electronic) Linking ISSN: 01632116 NLM ISO Abbreviation: Dig Dis Sci Subsets: MEDLINE
أسماء مطبوعة: Publication: 2005- : New York, NY : Springer Science + Business Media
Original Publication: New York, Plenum Pub. Corp.
مواضيع طبية MeSH: Pancreatic Cyst*/diagnosis , Pancreatic Cyst*/pathology , Pancreatic Neoplasms*/diagnosis , Pancreatic Neoplasms*/pathology, Carcinoembryonic Antigen ; Cyst Fluid/chemistry ; Diagnosis, Differential ; Female ; Glucose/analysis ; Humans ; Male ; Pancreas/pathology
مستخلص: Background: Carcinoembryonic antigen (CEA) in the pancreatic cystic fluid is the most important biomarker for differentiating mucinous from non-mucinous pancreatic cystic lesions (PCLs). However, recent studies have shown that glucose levels in pancreatic cystic fluid can discriminate mucinous from non-mucinous cysts.
Aims: To perform a meta-analysis to determine the utility of intracystic fluid glucose of pancreatic mucinous cysts compared with intracystic CEA.
Methods: We conducted a systematic review of the literature in the PubMed, OVID Medline, and Cochrane databases. This meta-analysis considers studies published up to October 2020.
Results: Six studies comprising 506 patients were selected; 61.2% of the population was female. Of the 480 PCLs, 287 (59.7%) were mucinous. Pooled sensitivity and specificity of cystic fluid glucose levels for mucinous PCLs were 91% and 85%, respectively. The positive likelihood ratio (PLR) and negative likelihood ratio (NLR) were 6.33 and 0.11, respectively. Pooled diagnostic odds ratio (DOR) was 60.94. The pooled area under the summary receiver operating characteristic (SROC) curve was 0.959. Pooled sensitivity and specificity of pancreatic cystic fluid CEA levels were 61% and 93%. The PLR and NLR were 8.51 and 0.40, respectively. Pooled DOR was 23.52, and the pooled area under the SROC curve was 0.861.
Conclusion: Glucose has become a useful method and appears to be better than CEA for differentiating between mucinous PCLs and non-mucinous PCLs. We suggest that the analysis of glucose in PCLs be routinely performed for the differential diagnosis of these lesions.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
التعليقات: Comment in: Dig Dis Sci. 2022 Jul;67(7):3466-3467. (PMID: 34319495)
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فهرسة مساهمة: Keywords: Carcinoembryonic antigen; Cystic fluids; Glucose; Pancreatic cystic lesions
المشرفين على المادة: 0 (Carcinoembryonic Antigen)
IY9XDZ35W2 (Glucose)
تواريخ الأحداث: Date Created: 20210519 Date Completed: 20220608 Latest Revision: 20220817
رمز التحديث: 20240829
DOI: 10.1007/s10620-021-07035-w
PMID: 34009555
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-2568
DOI:10.1007/s10620-021-07035-w