دورية أكاديمية
أعرض في EDS

Evaluation of optical coherence tomography angiography findings in patients with multiple sclerosis.

التفاصيل البيبلوغرافية
العنوان: Evaluation of optical coherence tomography angiography findings in patients with multiple sclerosis.
المؤلفون: Khader SA; Department of Ophthalmology, Faculty of Medicine, Tanta University, Tanta, Egypt., Nawar AE; Department of Ophthalmology, Faculty of Medicine, Tanta University, Tanta, Egypt., Ghali AA; Department of Neurology and Psychiatry, Faculty of Medicine, Tanta University, Tanta, Egypt., Ghoneim AM; Department of Ophthalmology, Faculty of Medicine, Tanta University, Tanta, Egypt.
المصدر: Indian journal of ophthalmology [Indian J Ophthalmol] 2021 Jun; Vol. 69 (6), pp. 1457-1463.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Medknow Publications Country of Publication: India NLM ID: 0405376 Publication Model: Print Cited Medium: Internet ISSN: 1998-3689 (Electronic) Linking ISSN: 03014738 NLM ISO Abbreviation: Indian J Ophthalmol Subsets: MEDLINE
أسماء مطبوعة: Publication: Mumbai : Medknow Publications
Original Publication: Bombay : All-India Ophthalmological Society
مواضيع طبية MeSH: Multiple Sclerosis*/complications , Multiple Sclerosis*/diagnosis , Tomography, Optical Coherence*, Angiography ; Humans ; Nerve Fibers ; Prospective Studies ; Retinal Ganglion Cells
مستخلص: Purpose: To evaluate optical coherence tomography angiography findings in patients with multiple sclerosis (MS).
Methods: This prospective noninterventional study was conducted on 30 eyes of relapsing-remitting MS patients. Group (1) included 10 eyes with a history of optic neuritis (ON), group (2) included 10 eyes without any history of optic neuritis (MS-ON), and group (3) included 10 eyes of normal age/sex/refraction matched participants. Optical coherence tomography (OCT) and OCT-A (ZEISS Cirrus™ HD-OCT Model 4000 (Carl Zeiss-Meditec, Dublin, CA) of the optic disc were done for all patients.
Results: The best-corrected visual acuity was diminished in MS cases, especially in patients with ON with P value <0.001. The retinal nerve fiber layer (RNFL) thickness showed a significant decrease in the average thickness and in all quadrants, notably the temporal quadrant in group 1 (P < 0.001). Ganglion cell layer thickness was diminished in average thickness and in all quadrants in both groups of MS, but only the first group showed statistical significance with P value <0.001). In respect to optic disc perfusion, Average, superficial, and deep vascular density index (AVDI, VDI 1, VDI 2) were statistically significantly lower in groups 1, 2 with (P-value < 0.001).
Conclusion: Decreased vascular perfusion of the optic nerve in MS patients, especially in those with ON is strongly correlated with the damage of RNFL and ganglion cell layer detected by OCT.
Competing Interests: None
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فهرسة مساهمة: Keywords: Ganglion cell layer; multiple sclerosis; optic neuritis; optical coherence tomography; optical coherence tomography angiography; retinal nerve fiber layer; vascular density index
تواريخ الأحداث: Date Created: 20210520 Date Completed: 20210527 Latest Revision: 20210803
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8302290
DOI: 10.4103/ijo.IJO_2964_20
PMID: 34011720
قاعدة البيانات: MEDLINE
الوصف
تدمد:1998-3689
DOI:10.4103/ijo.IJO_2964_20