دورية أكاديمية
أعرض في EDS

Meta-Analysis of Breast Cancer Risk in Levonorgestrel-Releasing Intrauterine System Users.

التفاصيل البيبلوغرافية
العنوان: Meta-Analysis of Breast Cancer Risk in Levonorgestrel-Releasing Intrauterine System Users.
المؤلفون: Silva FR; Laboratory of Biomedicine Translational, Postgraduate Program in Health Sciences, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil., Grande AJ; Laboratory of Evidence-Based Practice, Universidade Estadual de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., Lacerda Macedo AC; Laboratory of Biomedicine Translational, Postgraduate Program in Health Sciences, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil., Colonetti T; Laboratory of Biomedicine Translational, Postgraduate Program in Health Sciences, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil., Rocha MC; Laboratory of Biomedicine Translational, Postgraduate Program in Health Sciences, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil., Rodrigues Uggioni ML; Laboratory of Biomedicine Translational, Postgraduate Program in Health Sciences, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil., Silva BR; Laboratory of Biomedicine Translational, Postgraduate Program in Health Sciences, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil., da Rosa MI; Laboratory of Biomedicine Translational, Postgraduate Program in Health Sciences, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil. Electronic address: mir@unesc.net.
المصدر: Clinical breast cancer [Clin Breast Cancer] 2021 Dec; Vol. 21 (6), pp. 497-508. Date of Electronic Publication: 2021 Apr 03.
نوع المنشور: Journal Article; Meta-Analysis; Systematic Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 100898731 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1938-0666 (Electronic) Linking ISSN: 15268209 NLM ISO Abbreviation: Clin Breast Cancer Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011- : [New York] : Elsevier
Original Publication: Dallas, Tex. : Cancer Information Group
مواضيع طبية MeSH: Breast Neoplasms/*chemically induced , Contraceptive Agents, Female/*adverse effects , Intrauterine Devices, Medicated/*adverse effects , Levonorgestrel/*adverse effects, Breast Neoplasms/diagnosis ; Female ; Humans ; Risk Factors
مستخلص: To map and assess evidence regarding use of the levonorgestrel-releasing intrauterine system (LNG-IUS) and its association with breast cancer, we conducted a systematic review and meta-analysis. A search strategy was developed using the terms "Levonorgestrel-releasing," "LNG-IUS," "intrauterine system," and "breast cancer. The electronic databases searched were MEDLINE, Embase, Cochrane Library, Latin American & Caribbean Health Sciences Literature, and Google Scholar for studies published until August 2020. We included observational studies: prospective or retrospective cohort, case-control, and cross-sectional. A total of 494 studies were identified, 294 studies were evaluated by title and abstract, and 262 were excluded because they did not meet the inclusion criteria. A total of 32 studies were read in full, and 24 were excluded. Thus, eight studies were included in the systematic review. The meta-analysis included four studies (two cohort and two case-control studies). Two subgroup analyses were performed for different study designs. The estimated relative risk for the two cohort studies (144,996 cases), with moderate-quality evidence, was 0.93 (95% confidence interval [CI], 0.840-1.03). The odds ratio estimated for the two case-control studies (5556 cases and 35987 controls), with moderate-quality evidence, was 1.07 (95% CI, 0.91-1.26). Evidence of an increased risk of breast cancer was not observed in levonorgestrel-releasing intrauterine system users.
(Copyright © 2021. Published by Elsevier Inc.)
فهرسة مساهمة: Keywords: LNG-IUS; Levonorgestrel; Risk factor; Systematic review; Women
المشرفين على المادة: 0 (Contraceptive Agents, Female)
5W7SIA7YZW (Levonorgestrel)
تواريخ الأحداث: Date Created: 20210528 Date Completed: 20220127 Latest Revision: 20220127
رمز التحديث: 20240829
DOI: 10.1016/j.clbc.2021.03.013
PMID: 34045174
قاعدة البيانات: MEDLINE
الوصف
تدمد:1938-0666
DOI:10.1016/j.clbc.2021.03.013