دورية أكاديمية
أعرض في EDS

Alcohol consumption in the general population is associated with structural changes in multiple organ systems.

التفاصيل البيبلوغرافية
العنوان: Alcohol consumption in the general population is associated with structural changes in multiple organ systems.
المؤلفون: Evangelou E; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Suzuki H; Department of Cardiovascular Medicine, Tohoku University Hospital, Sendai, Japan.; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Department of Brain Sciences, Imperial College London, London, United Kingdom., Bai W; Department of Brain Sciences, Imperial College London, London, United Kingdom.; Data Science Institute, Imperial College London, London, United Kingdom., Pazoki R; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom.; Division of Biomedical Sciences, Department of Life Sciences, College of Health, Medicine and Life Sciences, Brunel University London, London, United Kingdom., Gao H; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom., Matthews PM; Department of Brain Sciences, Imperial College London, London, United Kingdom.; UK Dementia Research Institute at Imperial College London, London, United Kingdom.; National Institute for Health Research Imperial College Biomedical Research Centre, Imperial College London, London, United Kingdom., Elliott P; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom.; UK Dementia Research Institute at Imperial College London, London, United Kingdom.; National Institute for Health Research Imperial College Biomedical Research Centre, Imperial College London, London, United Kingdom.; British Heart Foundation Centre for Research Excellence, Imperial College London, London, United Kingdom.
المصدر: ELife [Elife] 2021 Jun 01; Vol. 10. Date of Electronic Publication: 2021 Jun 01.
نوع المنشور: Journal Article; Observational Study; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Magnetic Resonance Imaging*, Alcohol Drinking/*adverse effects , Alcohol-Induced Disorders/*diagnostic imaging, Aged ; Alcohol Drinking/epidemiology ; Alcohol-Induced Disorders/epidemiology ; Aorta/diagnostic imaging ; Brain/diagnostic imaging ; Brain Diseases/diagnostic imaging ; Brain Diseases/epidemiology ; Cardiomyopathy, Alcoholic/diagnostic imaging ; Cardiomyopathy, Alcoholic/epidemiology ; Fatty Liver, Alcoholic/diagnostic imaging ; Fatty Liver, Alcoholic/epidemiology ; Female ; Heart/diagnostic imaging ; Humans ; Liver/diagnostic imaging ; Male ; Middle Aged ; Predictive Value of Tests ; Prospective Studies ; Risk Assessment ; Risk Factors ; United Kingdom/epidemiology
مستخلص: Background: Excessive alcohol consumption is associated with damage to various organs, but its multi-organ effects have not been characterised across the usual range of alcohol drinking in a large general population sample.
Methods: We assessed global effect sizes of alcohol consumption on quantitative magnetic resonance imaging phenotypic measures of the brain, heart, aorta, and liver of UK Biobank participants who reported drinking alcohol.
Results: We found a monotonic association of higher alcohol consumption with lower normalised brain volume across the range of alcohol intakes (-1.7 × 10 -3 ± 0.76 × 10 -3 per doubling of alcohol consumption, p=3.0 × 10 -14 ). Alcohol consumption was also associated directly with measures of left ventricular mass index and left ventricular and atrial volume indices. Liver fat increased by a mean of 0.15% per doubling of alcohol consumption.
Conclusions: Our results imply that there is not a 'safe threshold' below which there are no toxic effects of alcohol. Current public health guidelines concerning alcohol consumption may need to be revisited.
Funding: See acknowledgements.
Competing Interests: EE E.E. acknowledges consultancy fees from OpenDNA, HS, WB, RP, HG, PE No competing interests declared, PM PM acknowledges consultancy fees from Roche, Adelphi Communications, Celgene and Biogen. He has received honoraria or speakers' honoraria from Novartis, Biogen, Medscape, Adelphi Communications and Roche and has received research or educational funds from Biogen, Novartis, GlaxoSmithKline and Nodthera.
(© 2021, Evangelou et al.)
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معلومات مُعتمدة: MR/K501013/1 United Kingdom MRC_ Medical Research Council; MR/R0265051/1 United Kingdom MRC_ Medical Research Council; MR/N026934/1 United Kingdom MRC_ Medical Research Council; United Kingdom DH_ Department of Health; MR/L01341X/1 United Kingdom MRC_ Medical Research Council; G0300665 United Kingdom MRC_ Medical Research Council; MC_PC_17114 United Kingdom MRC_ Medical Research Council; G9901399 United Kingdom MRC_ Medical Research Council; G0601966 United Kingdom MRC_ Medical Research Council; United Kingdom WT_ Wellcome Trust; MR/S019669/1 United Kingdom MRC_ Medical Research Council; MR/M024903/1 United Kingdom MRC_ Medical Research Council; MR/R0265051/2 United Kingdom MRC_ Medical Research Council; MC_PC_17228 United Kingdom MRC_ Medical Research Council; MR/R026505/2 United Kingdom MRC_ Medical Research Council; G0900897 United Kingdom MRC_ Medical Research Council; RE/18/4/34215 United Kingdom BHF_ British Heart Foundation; G9409634 United Kingdom MRC_ Medical Research Council; G0100811 United Kingdom MRC_ Medical Research Council; MC_QA137853 United Kingdom MRC_ Medical Research Council; G9409531 United Kingdom MRC_ Medical Research Council
فهرسة مساهمة: Keywords: alcohol consumption; aorta; brain; epidemiology; global health; heart; imaging; liver; none
تواريخ الأحداث: Date Created: 20210601 Date Completed: 20211019 Latest Revision: 20220716
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC8192119
DOI: 10.7554/eLife.65325
PMID: 34059199
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.65325