دورية أكاديمية
أعرض في EDS

Association of killer cell immunoglobulin-like receptors with endemic Burkitt lymphoma in Kenyan children.

التفاصيل البيبلوغرافية
العنوان: Association of killer cell immunoglobulin-like receptors with endemic Burkitt lymphoma in Kenyan children.
المؤلفون: Muriuki BM; West African Center for Cell Biology of Infectious Pathogens, College of Basic and Applied Sciences, University of Ghana, Accra, Ghana.; Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya., Forconi CS; Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA., Oluoch PO; Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.; Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA., Bailey JA; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, RI, USA., Ghansah A; Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra, Ghana., Moormann AM; Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA., Ong'echa JM; Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya. michaelongecha@yahoo.com.
المصدر: Scientific reports [Sci Rep] 2021 May 31; Vol. 11 (1), pp. 11343. Date of Electronic Publication: 2021 May 31.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Burkitt Lymphoma/*genetics , Receptors, KIR/*genetics, Adolescent ; Burkitt Lymphoma/epidemiology ; Burkitt Lymphoma/immunology ; Burkitt Lymphoma/virology ; Child ; Child, Preschool ; Endemic Diseases ; Genotype ; Herpesvirus 4, Human/isolation & purification ; Humans ; Infant ; Kenya/epidemiology ; Retrospective Studies ; Viral Load
مستخلص: Endemic Burkitt lymphoma (eBL) is an aggressive pediatric B cell lymphoma, common in Equatorial Africa. Co-infections with Epstein-Barr virus (EBV) and Plasmodium falciparum, coupled with c-myc translocation are involved in eBL etiology. Infection-induced immune evasion mechanisms to avoid T cell cytotoxicity may increase the role of Natural killer (NK) cells in anti-tumor immunosurveillance. Killer immunoglobulin-like receptor (KIR) genes on NK cells exhibit genotypic and allelic variations and are associated with susceptibility to diseases and malignancies. However, their role in eBL pathogenesis remains undefined. This retrospective study genotyped sixteen KIR genes and compared their frequencies in eBL patients (n = 104) and healthy geographically-matched children (n = 104) using sequence-specific primers polymerase chain reaction (SSP-PCR) technique. The relationship between KIR polymorphisms with EBV loads and eBL pathogenesis was investigated. Possession of ≥ 4 activating KIRs predisposed individuals to eBL (OR = 3.340; 95% CI 1.530-7.825; p = 0.004). High EBV levels were observed in Bx haplogroup (p = 0.016) and AB genotypes (p = 0.042) relative to AA haplogroup and AA genotype respectively, in eBL patients but not in healthy controls. Our results suggest that KIR-mediated NK cell stimulation could mute EBV control, contributing to eBL pathogenesis.
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معلومات مُعتمدة: United Kingdom WT_ Wellcome Trust; R01 CA189806 United States CA NCI NIH HHS; 107755/Z/15/Z United Kingdom WT_ Wellcome Trust
المشرفين على المادة: 0 (Receptors, KIR)
تواريخ الأحداث: Date Created: 20210601 Date Completed: 20211119 Latest Revision: 20240505
رمز التحديث: 20240505
مُعرف محوري في PubMed: PMC8166913
DOI: 10.1038/s41598-021-90596-7
PMID: 34059753
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-021-90596-7