دورية أكاديمية
High Resolution Mass Spectroscopy-Based Secondary Metabolite Profiling of Nymphaea nouchali (Burm. f) Stem Attenuates Oxidative Stress via Regulation of MAPK/Nrf2/HO-1/ROS Pathway.
| العنوان: | High Resolution Mass Spectroscopy-Based Secondary Metabolite Profiling of Nymphaea nouchali (Burm. f) Stem Attenuates Oxidative Stress via Regulation of MAPK/Nrf2/HO-1/ROS Pathway. |
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| المؤلفون: | Alam MB; Department of Food Science and Biotechnology, Graduate School, Kyungpook National University, Daegu 41566, Korea.; Food and Bio-Industry Research Institute, Inner Beauty/Antiaging Center, Kyungpook National University, Daegu 41566, Korea., Naznin M; Department of Chemistry, Kyungpook National University, Daegu 41566, Korea., Islam S; Department of Chemistry, Kyungpook National University, Daegu 41566, Korea., Alshammari FH; Department of Food Science and Biotechnology, Graduate School, Kyungpook National University, Daegu 41566, Korea., Choi HJ; Department of Food Science and Biotechnology, Graduate School, Kyungpook National University, Daegu 41566, Korea., Song BR; Department of Food Science and Biotechnology, Graduate School, Kyungpook National University, Daegu 41566, Korea., Kim S; Department of Chemistry, Kyungpook National University, Daegu 41566, Korea.; Mass Spectroscopy Converging Research Center and Green-Nano Materials Research Center, Daegu 41566, Korea., Lee SH; Department of Food Science and Biotechnology, Graduate School, Kyungpook National University, Daegu 41566, Korea.; Food and Bio-Industry Research Institute, Inner Beauty/Antiaging Center, Kyungpook National University, Daegu 41566, Korea.; Knu BnC, Daegu 41566, Korea. |
| المصدر: | Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2021 May 03; Vol. 10 (5). Date of Electronic Publication: 2021 May 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101668981 Publication Model: Electronic Cited Medium: Print ISSN: 2076-3921 (Print) Linking ISSN: 20763921 NLM ISO Abbreviation: Antioxidants (Basel) Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI AG, [2012]- |
| مستخلص: | The secondary metabolites profiling of Nymphaea nouchali stem (NNSE) extract was carried out using a high-resolution mass spectroscopic technique. The antioxidant effects of NNSE, as well as the underlying mechanisms, were also investigated in tert-butyl hydroperoxide ( t -BHP)-stimulated oxidative stress in RAW264.7 cells. Tandem mass spectroscopy with (-) negative mode tentatively revealed the presence of 54 secondary metabolites in NNSE. Among them, phenolic acids and flavonoids were predominant. Phenolic acids (brevifolincarboxylic acid, p -coumaroyltartaric acid, niazinin B, lalioside, 3-feruloylquinic acid, and gallic acid- O -rutinoside), flavonoids (elephantorrhizol, apigenin-6-C-galactoside 8-C-arabinoside, and vicenin-2), sialic acid (2-deoxy-2,3-dehydro-N-acetylneuraminic acid), and terpenoid (α-γ-onoceradienedione) were identified in NNSE for the first time. Unbridled reactive oxygen species/nitrogen species (ROS/RNS) and redox imbalances participate in the induction and development of many oxidative stress-linked diseases. The NNSE exhibited significant free radical scavenging capabilities and was also able to reduce t -BHP-induced cellular generation in RAW264.7 cells. The NNSE prevented oxidative stress by inducing the endogenous antioxidant system and the levels of heme oxygenase-1 (HO-1) by upregulating Nrf2 through the modulation of mitogen-activated protein kinases (MAPK), such as phosphorylated p38 and c-Jun N terminal kinase. Collectively, these results indicate that the NNSE exhibits potent effects in preventing oxidative stress-stimulated diseases and disorders through the modulation of the MAPK/Nrf2/HO-1 signaling pathway. Our findings provide new insights into the cytoprotective effects and mechanisms of Nymphaea nouchali stem extract against oxidative stress, which may be a useful remedy for oxidative stress-induced disorders. |
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| معلومات مُعتمدة: | 2020R1A2C2011495 National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT |
| فهرسة مساهمة: | Keywords: Dillenia indica; RAW264.7 cells; antioxidant; heme oxygenase 1 (HO-1); nuclear factor erythroid 2-related factor 2 |
| تواريخ الأحداث: | Date Created: 20210602 Latest Revision: 20210615 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC8147620 |
| DOI: | 10.3390/antiox10050719 |
| PMID: | 34063678 |
| قاعدة البيانات: | MEDLINE |
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