دورية أكاديمية
Molecular Biology of Pediatric and Adult Male Germ Cell Tumors.
| العنوان: | Molecular Biology of Pediatric and Adult Male Germ Cell Tumors. |
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| المؤلفون: | Pinto MT; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784400, Brazil.; Brazilian Childhood Germ Cell Tumor Study Group, The Brazilian Pediatric Oncology Society (SOBOPE), Barretos 14784400, Brazil., Cárcano FM; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784400, Brazil.; Department of Clinical Oncology, Barretos Cancer Hospital, Barretos 14784400, Brazil.; Barretos School of Health Sciences Dr. Paulo Prata-FACISB, Barretos 14785002, Brazil., Vieira AGS; Brazilian Childhood Germ Cell Tumor Study Group, The Brazilian Pediatric Oncology Society (SOBOPE), Barretos 14784400, Brazil.; Barretos Children's Cancer Hospital from Hospital de Amor, Barretos 14784400, Brazil., Cabral ERM; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784400, Brazil., Lopes LF; Brazilian Childhood Germ Cell Tumor Study Group, The Brazilian Pediatric Oncology Society (SOBOPE), Barretos 14784400, Brazil.; Barretos Children's Cancer Hospital from Hospital de Amor, Barretos 14784400, Brazil. |
| المصدر: | Cancers [Cancers (Basel)] 2021 May 13; Vol. 13 (10). Date of Electronic Publication: 2021 May 13. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI |
| مستخلص: | Cancer is a leading cause of death by disease in children and the second most prevalent of all causes in adults. Testicular germ cell tumors (TGCTs) make up 0.5% of pediatric malignancies, 14% of adolescent malignancies, and are the most common of malignancies in young adult men. Although the biology and clinical presentation of adult TGCTs share a significant overlap with those of the pediatric group, molecular evidence suggests that TGCTs in young children likely represent a distinct group compared to older adolescents and adults. The rarity of this cancer among pediatric ages is consistent with our current understanding, and few studies have analyzed and compared the molecular basis in childhood and adult cancers. Here, we review the major similarities and differences in cancer genetics, cytogenetics, epigenetics, and chemotherapy resistance between pediatric and adult TGCTs. Understanding the biological and molecular processes underlying TGCTs may help improve patient outcomes, and fuel further investigation and clinical research in childhood and adult TGCTs. |
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| فهرسة مساهمة: | Keywords: epigenomics; genomics; germ cell tumors; pediatric and adult; testicular cancer |
| تواريخ الأحداث: | Date Created: 20210602 Latest Revision: 20210605 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC8152248 |
| DOI: | 10.3390/cancers13102349 |
| PMID: | 34068019 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2072-6694 |
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| DOI: | 10.3390/cancers13102349 |