دورية أكاديمية
أعرض في EDS

Genomic and Phenotypic Analysis of Linezolid-Resistant Staphylococcus epidermidis in a Tertiary Hospital in Innsbruck, Austria.

التفاصيل البيبلوغرافية
العنوان: Genomic and Phenotypic Analysis of Linezolid-Resistant Staphylococcus epidermidis in a Tertiary Hospital in Innsbruck, Austria.
المؤلفون: Huber S; Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, 6020 Innsbruck, Austria., Knoll MA; Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, 6020 Innsbruck, Austria., Berktold M; Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, 6020 Innsbruck, Austria., Würzner R; Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, 6020 Innsbruck, Austria., Brindlmayer A; Center for Biomedical Technology, Department for Biomedical Research, Danube University Krems, 3500 Krems, Austria., Weber V; Center for Biomedical Technology, Department for Biomedical Research, Danube University Krems, 3500 Krems, Austria., Posch AE; Ares Genetics GmbH, 1030 Vienna, Austria., Mrazek K; Ares Genetics GmbH, 1030 Vienna, Austria., Lepuschitz S; Ares Genetics GmbH, 1030 Vienna, Austria., Ante M; Ares Genetics GmbH, 1030 Vienna, Austria., Beisken S; Ares Genetics GmbH, 1030 Vienna, Austria., Orth-Höller D; MB-LAB-Clinical Microbiology Laboratory, 6020 Innsbruck, Austria., Weinberger J; Ares Genetics GmbH, 1030 Vienna, Austria.
المصدر: Microorganisms [Microorganisms] 2021 May 10; Vol. 9 (5). Date of Electronic Publication: 2021 May 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101625893 Publication Model: Electronic Cited Medium: Print ISSN: 2076-2607 (Print) Linking ISSN: 20762607 NLM ISO Abbreviation: Microorganisms Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2013]-
مستخلص: Whole genome sequencing is a useful tool to monitor the spread of resistance mechanisms in bacteria. In this retrospective study, we investigated genetic resistance mechanisms, sequence types (ST) and respective phenotypes of linezolid-resistant Staphylococcus epidermidis (LRSE, n = 129) recovered from a cohort of patients receiving or not receiving linezolid within a tertiary hospital in Innsbruck, Austria. Hereby, the point mutation G2603U in the 23S rRNA ( n = 91) was the major resistance mechanism followed by the presence of plasmid-derived cfr ( n = 30). The majority of LRSE isolates were ST2 strains, followed by ST5. LRSE isolates expressed a high resistance level to linezolid with a minimal inhibitory concentration of ≥256 mg/L ( n = 83) in most isolates, particularly in strains carrying the cfr gene ( p < 0.001). Linezolid usage was the most prominent (but not the only) trigger for the development of linezolid resistance. However, administration of linezolid was not associated with a specific resistance mechanism. Restriction of linezolid usage and the monitoring of plasmid-derived cfr in LRSE are potential key steps to reduce linezolid resistance and its transmission to more pathogenic Gram-positive bacteria.
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معلومات مُعتمدة: W 1253 Austria FWF_ Austrian Science Fund FWF; 871243 Österreichische Forschungsförderungsgesellschaft
فهرسة مساهمة: Keywords: Staphylococcus epidermidis; antimicrobial resistance; linezolid; surveillance; whole genome sequencing
تواريخ الأحداث: Date Created: 20210602 Latest Revision: 20240402
رمز التحديث: 20240402
مُعرف محوري في PubMed: PMC8150687
DOI: 10.3390/microorganisms9051023
PMID: 34068744
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-2607
DOI:10.3390/microorganisms9051023