التفاصيل البيبلوغرافية
| العنوان: |
Recurrent vaginal epithelioid leiomyosarcoma; a case report from Botswana and review of the literature. |
| المؤلفون: |
Benti TM; University of Botswana, Faculty of Medicine, Department of Obstetrics and Gynecology., Mercy N; University of Botswana, Faculty of Medicine, Department of Obstetrics and Gynecology., Eshetu AB; University of Botswana Faculty of Medicine, Department of Pathology., Iwuh IE; Baylor College of Medicine Children's Foundation, Area 25 Hospital. Lilongwe., Kassa MW; University of Botswana Faculty of Medicine, Department of Anesthesia and Critical Care Medicine. |
| المصدر: |
African journal of reproductive health [Afr J Reprod Health] 2021 Feb; Vol. 25 (1), pp. 161-168. |
| نوع المنشور: |
Case Reports; Journal Article; Review |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Women's Health and Action Research Centre Country of Publication: Nigeria NLM ID: 9712263 Publication Model: Print Cited Medium: Internet ISSN: 1118-4841 (Print) Linking ISSN: 11184841 NLM ISO Abbreviation: Afr J Reprod Health Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Benin City, Edo State, Nigeria : Women's Health and Action Research Centre, c1997- |
| مواضيع طبية MeSH: |
Hysterectomy/*methods , Leiomyoma/*surgery , Leiomyosarcoma/*therapy , Radiotherapy, Adjuvant/*adverse effects , Salpingo-oophorectomy/*methods , Vaginal Neoplasms/*surgery, Botswana ; Female ; Humans ; Leiomyoma/pathology ; Leiomyosarcoma/pathology ; Leiomyosarcoma/secondary ; Leiomyosarcoma/surgery ; Middle Aged ; Neoplasm Recurrence, Local ; Treatment Outcome ; Uterine Neoplasms/pathology ; Uterine Neoplasms/therapy ; Vagina/pathology ; Vagina/surgery ; Vaginal Neoplasms/pathology |
| مستخلص: |
Primary vaginal leiomyosarcoma is a rare gynecological malignancy. The clinical presentation is a benign looking well circumscribed mobile mass which might however occasionally present with distant metastases. Post treatment recurrence is common, and the clinical course is often unpredictable. Primary surgical management plus radiotherapy is the commonly practiced treatment of choice. We report a case of primary vaginal epithelioid leiomyosarcoma that recurred twice after local surgical resection. The patient subsequently underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy for a recurrent vaginal leiomyosarcoma. Histopathology of the vaginal mass revealed an epithelioid leiomyosarcoma of the vagina. She also received a course of adjuvant radiotherapy. The patient was free of recurrence at 3 year follow up. Vaginal mass must be evaluated with a high index of suspicion for malignancy. Local surgical resection alone is insufficient for primary vaginal leiomyosarcoma. Surgical resection with adjuvant radiotherapy offers better treatment outcomes with decreased risk of recurrence. Empirical oophorectomy in patients with completed family size might confer additional benefit in preventing disease recurrence in resource limited settings where testing for estrogen and progesterone receptor status of the tumour is unavailable. Due to the unpredictable course of the disease, lifelong patient follow-up is critical for better outcomes. |
| فهرسة مساهمة: |
Keywords: Botswana; epithelioid leiomyosarcoma; radiotherapy; vaginal mass; vaginal sarcoma |
| تواريخ الأحداث: |
Date Created: 20210602 Date Completed: 20210616 Latest Revision: 20210616 |
| رمز التحديث: |
20221213 |
| DOI: |
10.29063/ajrh2021/v25i1.17 |
| PMID: |
34077121 |
| قاعدة البيانات: |
MEDLINE |
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