دورية أكاديمية
Designing Inherently Photodegradable Cell-Adhesive Hydrogels for 3D Cell Culture.
| العنوان: | Designing Inherently Photodegradable Cell-Adhesive Hydrogels for 3D Cell Culture. |
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| المؤلفون: | Rosenfeld A; Institute of Biological and Chemical Systems - Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen, 76344, Germany., Göckler T; Institute of Functional Interfaces (IFG), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen, 76344, Germany., Kuzina M; Institute of Biological and Chemical Systems - Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen, 76344, Germany., Reischl M; Institute for Automation and Applied Informatics (IAI), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen, 76344, Germany., Schepers U; Institute of Functional Interfaces (IFG), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen, 76344, Germany.; Institute of Organic Chemistry, Karlsruhe Institute of Technology (KIT), Karlsruhe, 76131, Germany., Levkin PA; Institute of Biological and Chemical Systems - Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen, 76344, Germany.; Institute of Organic Chemistry, Karlsruhe Institute of Technology (KIT), Karlsruhe, 76131, Germany. |
| المصدر: | Advanced healthcare materials [Adv Healthc Mater] 2021 Aug; Vol. 10 (16), pp. e2100632. Date of Electronic Publication: 2021 Jun 10. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Weinheim : Wiley-VCH, 2012- |
| مواضيع طبية MeSH: | Bioprinting* , Hydrogels*, Adhesives ; Cell Culture Techniques ; Gelatin ; Humans ; Tissue Engineering |
| مستخلص: | Light-based microfabrication techniques constitute an indispensable approach to fabricate tissue assemblies, benefiting from noncontact spatially and temporarily controlled manipulation of soft matter. Light-triggered degradation of soft materials, such as hydrogels, is important in tissue engineering, bioprinting, and related fields. The photoresponsiveness of hydrogels is generally not intrinsic and requires complex synthetic procedures wherein photoresponsive crosslinking groups are incorporated into the hydrogel. This paper demonstrates a novel biocompatible and inherently photodegradable poly(ethylene glycol) methacrylate (PEGMA)-based gelatin-methacryloyl (GelMA)-containing hydrogel that can be used to culture cells in 3D for at least 14 d. These gels are conveniently and quickly degraded via UV irradiation for 10 min to produce structured hydrogels of various geometries, sizes, and free-standing cell-laden hydrogel particles. These structures can be flexibly produced on demand. In particular, photodegradation can be temporarily delayed from photopolymerization, offering an alternative to hydrogel array production via photopolymerization with a photomask. The paper investigates the influences of hydrogel composition and swelling liquid on both its photodegradability and biocompatibility. (© 2021 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.) |
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| فهرسة مساهمة: | Keywords: gelatin-methacryloyl; hydrogels; photodegradation; poly(ethylene glycol) methacrylate; screening |
| المشرفين على المادة: | 0 (Adhesives) 0 (Hydrogels) 9000-70-8 (Gelatin) |
| تواريخ الأحداث: | Date Created: 20210610 Date Completed: 20210823 Latest Revision: 20210823 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1002/adhm.202100632 |
| PMID: | 34111332 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2192-2659 |
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| DOI: | 10.1002/adhm.202100632 |