دورية أكاديمية
Pulmonary Outcomes in Children Born Extremely and Very Preterm at 11 Years of Age.
| العنوان: | Pulmonary Outcomes in Children Born Extremely and Very Preterm at 11 Years of Age. |
|---|---|
| المؤلفون: | Di Filippo P; Department of Pediatrics, University of Chieti, Chieti, Italy.; Pediatric Allergy and Respiratory Unit, Department of Pediatrics, University of Chieti, Chieti, Italy., Giannini C; Department of Pediatrics, University of Chieti, Chieti, Italy., Attanasi M; Pediatric Allergy and Respiratory Unit, Department of Pediatrics, University of Chieti, Chieti, Italy., Dodi G; Department of Pediatrics, University of Chieti, Chieti, Italy.; Pediatric Allergy and Respiratory Unit, Department of Pediatrics, University of Chieti, Chieti, Italy., Scaparrotta A; Department of Pediatrics, University of Chieti, Chieti, Italy.; Pediatric Allergy and Respiratory Unit, Department of Pediatrics, University of Chieti, Chieti, Italy., Petrosino MI; Department of Pediatrics, University of Chieti, Chieti, Italy.; Pediatric Allergy and Respiratory Unit, Department of Pediatrics, University of Chieti, Chieti, Italy., Di Pillo S; Pediatric Allergy and Respiratory Unit, Department of Pediatrics, University of Chieti, Chieti, Italy., Chiarelli F; Department of Pediatrics, University of Chieti, Chieti, Italy. |
| المصدر: | Frontiers in pediatrics [Front Pediatr] 2021 May 25; Vol. 9, pp. 635503. Date of Electronic Publication: 2021 May 25 (Print Publication: 2021). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101615492 Publication Model: eCollection Cited Medium: Print ISSN: 2296-2360 (Print) Linking ISSN: 22962360 NLM ISO Abbreviation: Front Pediatr Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Media SA, [2013]- |
| مستخلص: | Background: There is increasing evidence of prematurity being a risk factor for long-term respiratory outcomes regardless the presence of bronchopulmonary dysplasia (BPD). Aim: To assess the effect of prematurity on respiratory outcomes in children born ≤32 weeks of gestational age at 11 years of age. Materials and Methods: Fifty five ex-preterm children (≤ 32 weeks of gestational age), born in Chieti between January 1, 2006 and December 31, 2007, performed lung function and diffusing capacity test (DLCO) at 11 years of age. Furthermore, allergy evaluation by skin prick test (SPT), eosinophil blood count and assessment of eosinophilic airways inflammation by exhaled nitric oxide (FeNO) were performed. The ex-preterm group was compared to an age- and sex-matched group of term children. Results: No difference for atopic and respiratory medical history was found between ex-preterm children and term controls, except for preschool wheezing that resulted more frequent in ex-preterm children. No difference neither in school-aged asthma frequency nor in lung function assessment at 11 years of age was found between the two groups. Lower DLCO values in ex-preterm children compared to term controls regardless the presence of BPD were found; furthermore, we showed a positive association between DLCO and gestational age. Eosinophil blood count, positive SPTs and FeNO values were similar between the two groups. Conclusions: Diffusing lung capacity was decreased in ex-preterm children at 11 years of age in the absence of lung function impairment and eosinophil airway inflammation, suggesting a non-eosinophilic pattern underlying pulmonary alterations. It could be desirable to include the diffusing capacity assessment in follow-up evaluation of all ex-preterm children. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Di Filippo, Giannini, Attanasi, Dodi, Scaparrotta, Petrosino, Di Pillo and Chiarelli.) |
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| فهرسة مساهمة: | Keywords: bronchopulmonar dysplasia; diffusing capacity for carbon monoxide; diffusing capacity for lung carbon monoxide; prematurity; preschool wheezing |
| تواريخ الأحداث: | Date Created: 20210611 Latest Revision: 20210612 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC8185052 |
| DOI: | 10.3389/fped.2021.635503 |
| PMID: | 34113584 |
| قاعدة البيانات: | MEDLINE |
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