دورية أكاديمية
Sialic acid O-acetylation: From biosynthesis to roles in health and disease.
| العنوان: | Sialic acid O-acetylation: From biosynthesis to roles in health and disease. |
|---|---|
| المؤلفون: | Visser EA; Institute for Molecules and Materials, Department of Synthetic Organic Chemistry, Radboud University Nijmegen, Nijmegen, the Netherlands., Moons SJ; Institute for Molecules and Materials, Department of Synthetic Organic Chemistry, Radboud University Nijmegen, Nijmegen, the Netherlands., Timmermans SBPE; Institute for Molecules and Materials, Department of Synthetic Organic Chemistry, Radboud University Nijmegen, Nijmegen, the Netherlands., de Jong H; Institute for Molecules and Materials, Department of Synthetic Organic Chemistry, Radboud University Nijmegen, Nijmegen, the Netherlands., Boltje TJ; Institute for Molecules and Materials, Department of Synthetic Organic Chemistry, Radboud University Nijmegen, Nijmegen, the Netherlands. Electronic address: t.boltje@ru.nl., Büll C; Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark; Hubrecht Institute, Utrecht, the Netherlands. Electronic address: c.bull@sund.ku.dk. |
| المصدر: | The Journal of biological chemistry [J Biol Chem] 2021 Aug; Vol. 297 (2), pp. 100906. Date of Electronic Publication: 2021 Jun 19. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [New York, NY] : Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Original Publication: Baltimore, MD : American Society for Biochemistry and Molecular Biology |
| مواضيع طبية MeSH: | Acetyltransferases/*metabolism , Carboxylic Ester Hydrolases/*metabolism , N-Acetylneuraminic Acid/*metabolism , Polysaccharides/*metabolism, Acetylation ; Animals ; Biosynthetic Pathways ; Disease ; Glycoproteins/metabolism ; Humans ; N-Acetylneuraminic Acid/chemistry ; Polysaccharides/chemistry |
| مستخلص: | Sialic acids are nine-carbon sugars that frequently cap glycans at the cell surface in cells of vertebrates as well as cells of certain types of invertebrates and bacteria. The nine-carbon backbone of sialic acids can undergo extensive enzymatic modification in nature and O-acetylation at the C-4/7/8/9 position in particular is widely observed. In recent years, the detection and analysis of O-acetylated sialic acids have advanced, and sialic acid-specific O-acetyltransferases (SOATs) and O-acetylesterases (SIAEs) that add and remove O-acetyl groups, respectively, have been identified and characterized in mammalian cells, invertebrates, bacteria, and viruses. These advances now allow us to draw a more complete picture of the biosynthetic pathway of the diverse O-acetylated sialic acids to drive the generation of genetically and biochemically engineered model cell lines and organisms with altered expression of O-acetylated sialic acids for dissection of their roles in glycoprotein stability, development, and immune recognition, as well as discovery of novel functions. Furthermore, a growing number of studies associate sialic acid O-acetylation with cancer, autoimmunity, and infection, providing rationale for the development of selective probes and inhibitors of SOATs and SIAEs. Here, we discuss the current insights into the biosynthesis and biological functions of O-acetylated sialic acids and review the evidence linking this modification to disease. Furthermore, we discuss emerging strategies for the design, synthesis, and potential application of unnatural O-acetylated sialic acids and inhibitors of SOATs and SIAEs that may enable therapeutic targeting of this versatile sialic acid modification. Competing Interests: Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article. (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.) |
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| فهرسة مساهمة: | Keywords: O-acetylation; glycan modifications; glycobiology; influenza C/D virus; sialic acid O-acetyl esterases (SIAEs); sialic acid O-acetyl transferases (SOATs); sialic acids |
| المشرفين على المادة: | 0 (Glycoproteins) 0 (Polysaccharides) EC 2.3.1.- (Acetyltransferases) EC 2.3.1.- (sialic acid O-acetyltransferase) EC 3.1.1.- (Carboxylic Ester Hydrolases) GZP2782OP0 (N-Acetylneuraminic Acid) |
| تواريخ الأحداث: | Date Created: 20210622 Date Completed: 20211203 Latest Revision: 20240403 |
| رمز التحديث: | 20240403 |
| مُعرف محوري في PubMed: | PMC8319020 |
| DOI: | 10.1016/j.jbc.2021.100906 |
| PMID: | 34157283 |
| قاعدة البيانات: | MEDLINE |
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