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Analgesic effect of central relaxin receptor activation on persistent inflammatory pain in mice: behavioral and neurochemical data.

التفاصيل البيبلوغرافية
العنوان: Analgesic effect of central relaxin receptor activation on persistent inflammatory pain in mice: behavioral and neurochemical data.
المؤلفون: Abboud C; Interdisciplinary Institute for Neuroscience, UMR 5297, University of Bordeaux, CNRS, Bordeaux, France.; Institute of Neurodegenerative Diseases, UMR 5393, CNRS, University of Bordeaux, Bordeaux, France.; Department of Biology, Faculty of Arts and Sciences, Holy Spirit University of Kaslik (USEK), Jounieh, Lebanon., Brochoire L; Institute of Neurodegenerative Diseases, UMR 5393, CNRS, University of Bordeaux, Bordeaux, France., Drouet A; Interdisciplinary Institute for Neuroscience, UMR 5297, University of Bordeaux, CNRS, Bordeaux, France., Hossain MA; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia., Hleihel W; Department of Biology, Faculty of Arts and Sciences, Holy Spirit University of Kaslik (USEK), Jounieh, Lebanon.; School of Medicine and Medical Sciences, Holy Spirit University of Kaslik (USEK), Jounieh, Lebanon., Gundlach AL; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia., Landry M; Institute of Neurodegenerative Diseases, UMR 5393, CNRS, University of Bordeaux, Bordeaux, France.; University of Bordeaux, CNRS, INSERM, Bordeaux Imaging Center, Bordeaux, France.
المصدر: Pain reports [Pain Rep] 2021 Jun 16; Vol. 6 (2), pp. e937. Date of Electronic Publication: 2021 Jun 16 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer Country of Publication: United States NLM ID: 101683899 Publication Model: eCollection Cited Medium: Internet ISSN: 2471-2531 (Electronic) Linking ISSN: 24712531 NLM ISO Abbreviation: Pain Rep Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Baltimore, MD : Wolters Kluwer, [2016]-
مستخلص: Introduction: The relaxin peptide signaling system is involved in diverse physiological processes, but its possible roles in the brain, including nociception, are largely unexplored.
Objective: In light of abundant expression of relaxin receptor (RXFP1) mRNA/protein in brain regions involved in pain processing, we investigated the effects of central RXFP1 activation on nociceptive behavior in a mouse model of inflammatory pain and examined the neurochemical phenotype and connectivity of relaxin and RXFP1 mRNA-positive neurons.
Methods: Mice were injected with Complete Freund Adjuvant (CFA) into a hind paw. After 4 days, the RXFP1 agonist peptides, H2-relaxin or B7-33, ± the RXFP1 antagonist, B-R13/17K-H2, were injected into the lateral cerebral ventricle, and mechanical and thermal sensitivity were assessed at 30 to 120 minutes. Relaxin and RXFP1 mRNA in excitatory and inhibitory neurons were examined using multiplex, fluorescent in situ hybridization. Relaxin-containing neurons were detected using immunohistochemistry and their projections assessed using fluorogold retrograde tract-tracing.
Results: Both H2-relaxin and B7-33 produced a strong, but transient, reduction in mechanical and thermal sensitivity of the CFA-injected hind paw alone, at 30 minutes postinjection. Notably, coinjection of B-R13/17K-H2 blocked mechanical, but not thermal, analgesia. In the claustrum, cingulate cortex, and subiculum, RXFP1 mRNA was expressed in excitatory neurons. Relaxin immunoreactivity was detected in neurons in forebrain and midbrain areas involved in pain processing and sending projections to the RXFP1-rich, claustrum and cingulate cortex. No changes were detected in CFA mice.
Conclusion: Our study identified a previously unexplored peptidergic system that can control pain processing in the brain and produce analgesia.
Competing Interests: The authors have no conflicts of interest to declare. This research was supported by grants from the French National Research Agency (A.N.R.)—RELAX Grant, Agreement 193992 (A.L.G. and M.L.), the National Health and Medical Research Council (NHMRC) of Australia (2001278 [M.A.H.] and 1067522 [A.L.G.]). C. Abboud was the recipient of a postgraduate scholarship from the “Centre National de la Recherche Scientifique Libanais” (Lebanon). Imaging was performed at the Bordeaux Imaging Center, a member of the France BioImaging national infrastructure (ANR-10-INBS-04).Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.
(Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain.)
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فهرسة مساهمة: Keywords: Chronic pain; G-protein-coupled receptor; RXFP1; Relaxin
تواريخ الأحداث: Date Created: 20210623 Latest Revision: 20220424
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC8213244
DOI: 10.1097/PR9.0000000000000937
PMID: 34159282
قاعدة البيانات: MEDLINE
الوصف
تدمد:2471-2531
DOI:10.1097/PR9.0000000000000937