دورية أكاديمية
Brain iron enrichment attenuates α-synuclein spreading after injection of preformed fibrils.
| العنوان: | Brain iron enrichment attenuates α-synuclein spreading after injection of preformed fibrils. |
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| المؤلفون: | Dauer Née Joppe K; Department of Neurology, University Medical Center Goettingen, Goettingen, Germany.; Center for Biostructural Imaging of Neurodegeneration, University Medical Center Goettingen, Goettingen, Germany., Tatenhorst L; Department of Neurology, University Medical Center Goettingen, Goettingen, Germany.; Center for Biostructural Imaging of Neurodegeneration, University Medical Center Goettingen, Goettingen, Germany., Caldi Gomes L; Department of Neurology, University Medical Center Goettingen, Goettingen, Germany.; Center for Biostructural Imaging of Neurodegeneration, University Medical Center Goettingen, Goettingen, Germany.; Department of Neurology, School of Medicine, University Hospital rechts der Isar, Technical University of Munich, Munich, Germany., Zhang S; Department of Neurology, School of Medicine, University Hospital rechts der Isar, Technical University of Munich, Munich, Germany., Parvaz M; Department of Neurology, School of Medicine, University Hospital rechts der Isar, Technical University of Munich, Munich, Germany., Carboni E; Department of Neurology, University Medical Center Goettingen, Goettingen, Germany., Roser AE; Department of Neurology, University Medical Center Goettingen, Goettingen, Germany.; Center for Biostructural Imaging of Neurodegeneration, University Medical Center Goettingen, Goettingen, Germany., El DeBakey H; Department of Neurology, University Hospital of Wuerzburg, Wuerzburg, Germany., Bähr M; Department of Neurology, University Medical Center Goettingen, Goettingen, Germany.; Center for Biostructural Imaging of Neurodegeneration, University Medical Center Goettingen, Goettingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Goettingen, Goettingen, Germany., Vogel-Mikuš K; Biotechnical faculty, University of Ljubljana, Ljubljana, Slovenia.; Jozef Stefan Institute, Ljubljana, Slovenia., Wang Ip C; Department of Neurology, University Hospital of Wuerzburg, Wuerzburg, Germany., Becker S; Department of NMR Based Structural Biology, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany., Zweckstetter M; Department of Neurology, University Medical Center Goettingen, Goettingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.; Research group Mass Spectrometry, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany., Lingor P; Department of Neurology, University Medical Center Goettingen, Goettingen, Germany.; Center for Biostructural Imaging of Neurodegeneration, University Medical Center Goettingen, Goettingen, Germany.; Department of Neurology, School of Medicine, University Hospital rechts der Isar, Technical University of Munich, Munich, Germany. |
| المصدر: | Journal of neurochemistry [J Neurochem] 2021 Nov; Vol. 159 (3), pp. 554-573. Date of Electronic Publication: 2021 Aug 02. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-4159 (Electronic) Linking ISSN: 00223042 NLM ISO Abbreviation: J Neurochem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2001- : Oxford, UK : Wiley on behalf of the International Society for Neurochemistry Original Publication: New York : Raven Press |
| مواضيع طبية MeSH: | Brain Chemistry*, Iron/*pharmacology , Synucleinopathies/*metabolism , Synucleinopathies/*pathology , alpha-Synuclein/*metabolism , alpha-Synuclein/*toxicity, Animals ; Animals, Newborn ; Connectome ; Corpus Striatum ; Dose-Response Relationship, Drug ; Female ; Humans ; Iron/administration & dosage ; Male ; Memory Disorders/chemically induced ; Memory Disorders/psychology ; Mice, Inbred C57BL ; Microglia/pathology ; Microinjections ; Motor Activity/drug effects ; alpha-Synuclein/administration & dosage ; Mice |
| مستخلص: | Regional iron accumulation and α-synuclein (α-syn) spreading pathology within the central nervous system are common pathological findings in Parkinson's disease (PD). Whereas iron is known to bind to α-syn, facilitating its aggregation and regulating α-syn expression, it remains unclear if and how iron also modulates α-syn spreading. To elucidate the influence of iron on the propagation of α-syn pathology, we investigated α-syn spreading after stereotactic injection of α-syn preformed fibrils (PFFs) into the striatum of mouse brains after neonatal brain iron enrichment. C57Bl/6J mouse pups received oral gavage with 60, 120, or 240 mg/kg carbonyl iron or vehicle between postnatal days 10 and 17. At 12 weeks of age, intrastriatal injections of 5-µg PFFs were performed to induce seeding of α-syn aggregates. At 90 days post-injection, PFFs-injected mice displayed long-term memory deficits, without affection of motor behavior. Interestingly, quantification of α-syn phosphorylated at S129 showed reduced α-syn pathology and attenuated spreading to connectome-specific brain regions after brain iron enrichment. Furthermore, PFFs injection caused intrastriatal microglia accumulation, which was alleviated by iron in a dose-dependent way. In primary cortical neurons in a microfluidic chamber model in vitro, iron application did not alter trans-synaptic α-syn propagation, possibly indicating an involvement of non-neuronal cells in this process. Our study suggests that α-syn PFFs may induce cognitive deficits in mice independent of iron. However, a redistribution of α-syn aggregate pathology and reduction of striatal microglia accumulation in the mouse brain may be mediated via iron-induced alterations of the brain connectome. (© 2021 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry.) |
| التعليقات: | Comment in: J Neurochem. 2021 Nov;159(3):414-416. (PMID: 34296424) |
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| فهرسة مساهمة: | Keywords: Parkinson's disease; alpha-synuclein; alpha-synuclein propagation; alpha-synuclein seeding; iron dyshomeostasis |
| المشرفين على المادة: | 0 (alpha-Synuclein) E1UOL152H7 (Iron) |
| تواريخ الأحداث: | Date Created: 20210627 Date Completed: 20211119 Latest Revision: 20240226 |
| رمز التحديث: | 20240226 |
| DOI: | 10.1111/jnc.15461 |
| PMID: | 34176164 |
| قاعدة البيانات: | MEDLINE |
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