دورية أكاديمية
Effect of Antibacterial Root Canal Sealer on Persistent Apical Periodontitis.
العنوان: | Effect of Antibacterial Root Canal Sealer on Persistent Apical Periodontitis. |
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المؤلفون: | Wang Z; State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, China., Yang G; State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, China., Ren B; State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, China., Gao Y; State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, China., Peng X; State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, China., Li M; State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, China., H K Xu H; Department of Advanced Oral Sciences and Therapeutics, Biomaterials & Tissue Engineering Division, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA., Han Q; State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, China., Li J; State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, China., Zhou X; State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, China., Cheng L; State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, China. |
المصدر: | Antibiotics (Basel, Switzerland) [Antibiotics (Basel)] 2021 Jun 18; Vol. 10 (6). Date of Electronic Publication: 2021 Jun 18. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101637404 Publication Model: Electronic Cited Medium: Print ISSN: 2079-6382 (Print) Linking ISSN: 20796382 NLM ISO Abbreviation: Antibiotics (Basel) Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI AG, 2012- |
مستخلص: | The infection of Enterococcus faecalis and its interacting microorganisms in the root canal could cause persistent apical periodontitis (AP). Antibacterial root canal sealer has favorable prospects to inhibit biofilms. The purpose of this study was to investigated the antibacterial effect of root canal sealer containing dimethylaminododecyl methacrylate (DMADDM) on persistent AP in beagle dogs for the first time. Persistent AP was established by a two-step infection with Enterococcus faecalis and multi-bacteria ( Enterococcus faecalis , Lactobacillus acidophilus , Actinomyces naeslundii , Streptococcus gordonii ). Root canal sealer containing DMADDM (0%, 1.25%, 2.5%) was used to complete root canal filling. The volume of lesions and inflammatory grade in the apical area were evaluated by cone beam computer tomography (CBCT) and hematoxylin-eosin staining. Both Enterococcus-faecalis- and multi-bacteria-induced persistent AP caused severe apical destruction, and there were no significant differences in pathogenicity between them. DMADDM-modified sealer significantly reduced the volume of periapical lesion and inflammatory grade compared with the control group, among them, the therapeutic effect of the 2.5% group was better than the 1.25% group. In addition, E. faecalis -induced reinfection was more sensitive to the 2.5% group than multi-bacteria reinfection. This study shows that root canal sealer containing DMADDM had a remarkable therapeutic effect on persistent AP, especially on E. faecalis -induced reinfection. |
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معلومات مُعتمدة: | 81870759 National Natural Science Foundation of China; 82071106 National Natural Science Foundation of China; 81870778 National Natural Science Foundation of China; 81991500 National Natural Science Foundation of China; 81991501 National Natural Science Foundation of China; 2017HH0008 International Science and Technology Program of Sichuan |
فهرسة مساهمة: | Keywords: Enterococcus faecalis; beagle dogs; dimethylaminododecyl methacrylate; persistent apical periodontitis; root canal sealer |
تواريخ الأحداث: | Date Created: 20210702 Latest Revision: 20210710 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC8233789 |
DOI: | 10.3390/antibiotics10060741 |
PMID: | 34207470 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2079-6382 |
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DOI: | 10.3390/antibiotics10060741 |