دورية أكاديمية
Functional multigenic variations associated with hodgkin lymphoma.
| العنوان: | Functional multigenic variations associated with hodgkin lymphoma. |
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| المؤلفون: | Osman Y; Pathology Department, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Elsharkawy T; Pathology Department, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Hashim TM; Pathology Department, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Alratroot JA; Pathology Department, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Alsuwat HS; Department of Genetic Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Otaibi WMA; Department of Genetic Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Hegazi FM; Department of Genetic Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., AbdulAzeez S; Department of Genetic Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Borgio JF; Department of Genetic Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. |
| المصدر: | International journal of laboratory hematology [Int J Lab Hematol] 2021 Dec; Vol. 43 (6), pp. 1472-1482. Date of Electronic Publication: 2021 Jul 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 101300213 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1751-553X (Electronic) Linking ISSN: 17515521 NLM ISO Abbreviation: Int J Lab Hematol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Blackwell Scientific Publications, c2007- |
| مواضيع طبية MeSH: | Genetic Association Studies*/methods , Genetic Heterogeneity* , Genetic Predisposition to Disease* , Genetic Variation*, Hodgkin Disease/*diagnosis , Hodgkin Disease/*etiology, Alleles ; Case-Control Studies ; Genotype ; Haplotypes ; Humans ; Phenotype ; Polymorphism, Single Nucleotide ; Saudi Arabia ; Exome Sequencing |
| مستخلص: | Introduction: The current study aimed to describe genotypes associated with Hodgkin lymphoma (HL) in a cohort of Saudi and non-Saudi patients and discuss their possible susceptibility to HL. Methods: We studied clinical, histopathological, and laboratory findings of HL patients admitted over 12 years duration, at King Fahd University Hospital, KSA. The genomic DNAs of HL patients (n = 61) and normal control subjects (n = 36) were extracted, and genotyping was performed using the Illumina human exome bead chip. Set of HL patients and set of normal controls were included in this study. Results: A total of 35 DNA variants were found to be highly significant with the P-value <9.90 × 10 -11 among 243 345 exonic biomarkers and obeying the Hardy-Weinberg equilibrium. Nine, MEGF11-rs150945752 (P-value 1.20 × 10 -12 ), CACNA1I- s58055559 (P-value 1.93 × 10 -12 ), DECR2-rs146760080 (P-value 2.19 × 10 -12 ), STAB1-rs143894786 (P-value 2.45 × 10 -12 ), ZNF526-rs144433879 (P-value 2.76 × 10 -12 ), CPLANE1-rs200612080 (P-value 3.77 × 10 -12 ), DLK1-rs1058009 (P-value 5.95 × 10 -12 ), RTN4RL2-rs61745214 (P-value 7.71 × 10 -12 ), and PGRMC1-rs145582672 (P-value 8.56 × 10 -12 ), exonic variants on chromosomes 15, 22, and 16 were highly associated with HL cases. THE HIGHLY SIGNIFICANT HAPLOTYPES AT CHROMOSOME 3: rs143894786G; rs149982219G with P-value = 3.43 × 10 -14 was found to be the risk haplotype for the HL patients. The opposite alleles at chromosome 3: rs143894786A; rs149982219G is protective with P-value = 2.46 × 10 -12 . Maximum number of SNPs at the chromosome 19: rs144433879C; rs181265966G; rs201144421C; rs145591797G; rs200560875G; rs77270337G (risk P-value = 2.24 × 10 -12 ) and its opposite allele rs144433879A; rs181265966A; rs201144421T; rs145591797A; rs200560875A; rs77270337A (protective P-value = 2.60 × 10 -9 ) were found to be associated haplotype with the HL and controls, respectively, in Saudi population. Conclusion: Our study concludes that the HL is genetically heterogeneous with multigene causation. (© 2021 John Wiley & Sons Ltd.) |
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| معلومات مُعتمدة: | The Deanship of Scientific Research; 2017-135-IRMC Imam Abdulrahman Bin Faisal University |
| فهرسة مساهمة: | Keywords: hodgkin lymphoma; microarray; multigenic variations |
| تواريخ الأحداث: | Date Created: 20210703 Date Completed: 20211214 Latest Revision: 20221207 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1111/ijlh.13644 |
| PMID: | 34216518 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1751-553X |
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| DOI: | 10.1111/ijlh.13644 |