دورية أكاديمية
Renal sinus fat volume in type 2 diabetes mellitus is associated with glycated hemoglobin and metabolic risk factors.
| العنوان: | Renal sinus fat volume in type 2 diabetes mellitus is associated with glycated hemoglobin and metabolic risk factors. |
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| المؤلفون: | Lin L; Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, the Netherlands. Electronic address: l.lin@lumc.nl., Dekkers IA; Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, the Netherlands., Huang L; Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Qiaokou District, Wuhan, Hubei, China., Tao Q; Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, the Netherlands., Paiman EHM; Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, the Netherlands., Bizino MB; Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, the Netherlands., Jazet IM; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, the Netherlands., Lamb HJ; Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, the Netherlands. |
| المصدر: | Journal of diabetes and its complications [J Diabetes Complications] 2021 Sep; Vol. 35 (9), pp. 107973. Date of Electronic Publication: 2021 Jun 15. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Pub. Co Country of Publication: United States NLM ID: 9204583 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-460X (Electronic) Linking ISSN: 10568727 NLM ISO Abbreviation: J Diabetes Complications Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Elsevier Science Pub. Co., c1992- |
| مواضيع طبية MeSH: | Diabetes Mellitus, Type 2*/complications , Diabetic Nephropathies*/diagnosis , Diabetic Nephropathies*/epidemiology, Adipose Tissue/*pathology , Kidney/*pathology, Adult ; Aged ; Albuminuria ; Creatinine/urine ; Cross-Sectional Studies ; Female ; Glycated Hemoglobin/analysis ; Humans ; Male ; Middle Aged ; Risk Factors |
| مستخلص: | Aims: We aimed to compare renal sinus fat volume assessed by MRI between patients with type 2 diabetes and healthy volunteers, and investigate the association between renal sinus fat and metabolic traits. Methods: In this cross-sectional study, renal sinus fat and parenchyma volumes measured on abdominal MRI were compared between patients and controls using analysis of covariance. Associations of renal parameters with clinical characteristics were analyzed using linear regression analysis. Results: A total of 146 participants were enrolled, consisting of 95 type 2 diabetes patients (57.2±8.8years, 49.5% male) and 51 controls (54.0±9.2years, 43.1% male). Patients with diabetes demonstrated larger sinus fat volumes (15.4±7.5cm 3 vs. 10.3±7.1cm 3 , p<0.001) and sinus fat-parenchyma ratio than controls. In the total population, renal sinus fat was positively associated with HbA1c, abdominal VAT, cholesterol and triglycerides, after adjustment for age, sex, ethnicity and type 2 diabetes. In type 2 diabetes patients, increased sinus fat volume was significantly associated with urinary albumin-to-creatinine ratio. Conclusion: Renal sinus fat volume is positively associated with several metabolic risk factors including HbA1c level and urinary albumin-to-creatinine ratio in type 2 diabetes patients, indicating a potential role of renal sinus fat in the development of diabetic nephropathy. Future studies are needed to investigate whether sinus fat volume can serve as an early biomarker for diabetic nephropathy. (Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Diabetic nephropathy; Glycated hemoglobin; Magnetic resonance imaging; Renal sinus fat; Type 2 diabetes mellitus |
| المشرفين على المادة: | 0 (Glycated Hemoglobin A) AYI8EX34EU (Creatinine) |
| تواريخ الأحداث: | Date Created: 20210704 Date Completed: 20220114 Latest Revision: 20221207 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.jdiacomp.2021.107973 |
| PMID: | 34217586 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1873-460X |
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| DOI: | 10.1016/j.jdiacomp.2021.107973 |