دورية أكاديمية
Gastrointestinal digestion of dietary advanced glycation endproducts increases their pro-inflammatory potential.
| العنوان: | Gastrointestinal digestion of dietary advanced glycation endproducts increases their pro-inflammatory potential. |
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| المؤلفون: | van der Lugt T; Department of Pharmacology and Toxicology, Maastricht University, Maastricht, The Netherlands. t.vanderlugt@nvwa.nl., Vrolijk MF, Bovee TFH, van Leeuwen SPJ, Vonsovic S, Hamers A, Opperhuizen A, Bast A |
| المصدر: | Food & function [Food Funct] 2021 Aug 02; Vol. 12 (15), pp. 6691-6696. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101549033 Publication Model: Print Cited Medium: Internet ISSN: 2042-650X (Electronic) Linking ISSN: 20426496 NLM ISO Abbreviation: Food Funct Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge : Royal Society of Chemistry |
| مواضيع طبية MeSH: | Digestion/*physiology , Gastrointestinal Tract/*metabolism , Glycation End Products, Advanced/*immunology , Glycation End Products, Advanced/*metabolism, Caseins/immunology ; Caseins/metabolism ; Cell Line ; Humans ; Macrophages/metabolism ; Tumor Necrosis Factor-alpha/metabolism |
| مستخلص: | Thermal treatment of food products leads to the formation of dietary advanced glycation endproducts (dAGEs). It was previously shown that dAGEs induce TNF-α secretion in human macrophage-like cells. To what extent gastrointestinal digestion of dAGEs influences these pro-inflammatory effects and what the implications of these pro-inflammatory characteristics further down the human gastrointestinal tract are, are currently unknown. In one of our previous studies, dAGEs were digested using the TNO gastroIntestinal Model and analysed for dAGE quantity after digestion. In the current study both digested and undigested dAGEs were used to expose human macrophage-like cells, which were subsequently analysed for TNF-α secretion. In addition, the obtained digests were fractionated, and human macrophage-like cells were exposed to the different fractions to determine whether specific fractions induce TNF-α secretion. The results show that digested dAGEs have an increased pro-inflammatory effect on human macrophage-like cells compared to undigested dAGEs. This paper therefore shows that the digestion of food-components, and specifically dAGEs, plays an important role in determining their biological activity. |
| المشرفين على المادة: | 0 (Caseins) 0 (Glycation End Products, Advanced) 0 (Tumor Necrosis Factor-alpha) |
| تواريخ الأحداث: | Date Created: 20210705 Date Completed: 20220119 Latest Revision: 20220119 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1039/d1fo00956g |
| PMID: | 34219131 |
| قاعدة البيانات: | MEDLINE |
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