دورية أكاديمية
Combining reverse end-to-side neurorrhaphy with rapamycin treatment on chronically denervated muscle in rats.
| العنوان: | Combining reverse end-to-side neurorrhaphy with rapamycin treatment on chronically denervated muscle in rats. |
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| المؤلفون: | Chen Y; Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 510000 Guangzhou, Guangdong, China., Yuan W; Department of Orthopedics, Peking University Third Hospital, Beijing Key Laboratory of Spinal Disease, 100044 Beijing, China., Zeng X; Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 510000 Guangzhou, Guangdong, China., Ma Y; Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 510000 Guangzhou, Guangdong, China., Zheng Q; Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 510000 Guangzhou, Guangdong, China., Lin B; Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 510000 Guangzhou, Guangdong, China., Li Q; Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 510000 Guangzhou, Guangdong, China. |
| المصدر: | Journal of integrative neuroscience [J Integr Neurosci] 2021 Jun 30; Vol. 20 (2), pp. 359-366. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: IMR Press Country of Publication: Singapore NLM ID: 101156357 Publication Model: Print Cited Medium: Internet ISSN: 0219-6352 (Print) Linking ISSN: 02196352 NLM ISO Abbreviation: J Integr Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021-: Singapore : IMR Press Original Publication: London : Imperial College Press, c2002- |
| مواضيع طبية MeSH: | Neurosurgical Procedures*, Anti-Bacterial Agents/*pharmacology , Muscle, Skeletal/*physiopathology , Nerve Regeneration/*physiology , Peripheral Nerve Injuries/*therapy , Sirolimus/*pharmacology , Tibial Neuropathy/*therapy, Animals ; Anti-Bacterial Agents/administration & dosage ; Combined Modality Therapy ; Disease Models, Animal ; Electromyography ; Female ; Muscle Denervation ; Peripheral Nerve Injuries/drug therapy ; Peripheral Nerve Injuries/surgery ; Rats ; Rats, Sprague-Dawley ; Sirolimus/administration & dosage ; Tibial Neuropathy/drug therapy ; Tibial Neuropathy/surgery |
| مستخلص: | This preliminary research determines whether a combination of reverse end-to-side neurorrhaphy and rapamycin treatment achieves a better functional outcome than a single application after prolonged peripheral nerve injury. We found that the tibial nerve function of the reverse end-to-side + rapamycin group recovered better, with a higher tibial function index value, higher amplitude recovery rate, and shorter latency delay rate ( P < 0.05). The reverse end-to-side + rapamycin group better protected the gastrocnemius muscle with more forceful contractility, tetanic tension, and a higher myofibril cross-sectional area ( P < 0.05). Combining reverse end-to-side neurorrhaphy with rapamycin treatment is a practical approach to promoting the recovery of chronically denervated muscle atrophy after peripheral nerve injury. Competing Interests: The authors declare no conflict of interest. (© 2021 The Author(s). Published by IMR Press.) |
| معلومات مُعتمدة: | 2015B020225007 Major Science and Technology Project of Guangdong Province; 2018A0303130206 Natural Science Foundation of Guangdong Province; 2021A1515011008 Natural Science Foundation of Guangdong Province; A2019150 Guangdong Medical Science and Technology Research Fund; 201904010424 Program of Science and Technology of Guangzhou |
| فهرسة مساهمة: | Keywords: Muscle denervation; Nerve regeneration; Peripheral nerve injury; Rapamycin; Reverse end-to-side neurorrhaphy |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) W36ZG6FT64 (Sirolimus) |
| تواريخ الأحداث: | Date Created: 20210714 Date Completed: 20220124 Latest Revision: 20220124 |
| رمز التحديث: | 20221213 |
| DOI: | 10.31083/j.jin2002035 |
| PMID: | 34258934 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0219-6352 |
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| DOI: | 10.31083/j.jin2002035 |