دورية أكاديمية
أعرض في EDS

Metabolism and biomarkers of heterocyclic aromatic amines in humans.

التفاصيل البيبلوغرافية
العنوان: Metabolism and biomarkers of heterocyclic aromatic amines in humans.
المؤلفون: Bellamri M; Masonic Cancer Center and Department of Medicinal Chemistry, Cancer and Cardiovascular Research Building, University of Minnesota, 2231 6th Street, Minneapolis, MN, 55455, USA.; Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN, 55455, USA., Walmsley SJ; Masonic Cancer Center and Department of Medicinal Chemistry, Cancer and Cardiovascular Research Building, University of Minnesota, 2231 6th Street, Minneapolis, MN, 55455, USA.; Institute of Health Informatics, University of Minnesota, Minneapolis, MN, 55455, USA., Turesky RJ; Masonic Cancer Center and Department of Medicinal Chemistry, Cancer and Cardiovascular Research Building, University of Minnesota, 2231 6th Street, Minneapolis, MN, 55455, USA. Rturesky@umn.edu.; Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN, 55455, USA. Rturesky@umn.edu.
المصدر: Genes and environment : the official journal of the Japanese Environmental Mutagen Society [Genes Environ] 2021 Jul 16; Vol. 43 (1), pp. 29. Date of Electronic Publication: 2021 Jul 16.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101285347 Publication Model: Electronic Cited Medium: Print ISSN: 1880-7046 (Print) Linking ISSN: 18807046 NLM ISO Abbreviation: Genes Environ Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2015- : London : BioMed Central
Original Publication: Tokyo, Japan : Japanese Environmental Mutagen Society, c2006-
مستخلص: Heterocyclic aromatic amines (HAAs) form during the high-temperature cooking of meats, poultry, and fish. Some HAAs also arise during the combustion of tobacco. HAAs are multisite carcinogens in rodents, inducing cancer of the liver, gastrointestinal tract, pancreas, mammary, and prostate glands. HAAs undergo metabolic activation by N-hydroxylation of the exocyclic amine groups to produce the proposed reactive intermediate, the heteroaryl nitrenium ion, which is the critical metabolite implicated in DNA damage and genotoxicity. Humans efficiently convert HAAs to these reactive intermediates, resulting in HAA protein and DNA adduct formation. Some epidemiologic studies have reported an association between frequent consumption of well-done cooked meats and elevated cancer risk of the colorectum, pancreas, and prostate. However, other studies have reported no associations between cooked meat and these cancer sites. A significant limitation in epidemiology studies assessing the role of HAAs and cooked meat in cancer risk is their reliance on food frequency questionnaires (FFQ) to gauge HAA exposure. FFQs are problematic because of limitations in self-reported dietary history accuracy, and estimating HAA intake formed in cooked meats at the parts-per-billion level is challenging. There is a critical need to establish long-lived biomarkers of HAAs for implementation in molecular epidemiology studies designed to assess the role of HAAs in health risk. This review article highlights the mechanisms of HAA formation, mutagenesis and carcinogenesis, the metabolism of several prominent HAAs, and the impact of critical xenobiotic-metabolizing enzymes on biological effects. The analytical approaches that have successfully biomonitored HAAs and their biomarkers for molecular epidemiology studies are presented.
(© 2021. The Author(s).)
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معلومات مُعتمدة: P30 CA077598 United States CA NCI NIH HHS; R01 CA122320 United States CA NCI NIH HHS; R01CA122320 Foundation for the National Institutes of Health; CA077598 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: Biomarkers; Cancer; Cooked meat; Heterocyclic aromatic amines; Metabolism; Mutagens
تواريخ الأحداث: Date Created: 20210717 Latest Revision: 20210721
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8284014
DOI: 10.1186/s41021-021-00200-7
PMID: 34271992
قاعدة البيانات: MEDLINE
الوصف
تدمد:1880-7046
DOI:10.1186/s41021-021-00200-7