دورية أكاديمية
أعرض في EDS

Incidence of Plasmodium falciparum malaria infection in 6-month to 45-year-olds on selected areas of Bioko Island, Equatorial Guinea.

التفاصيل البيبلوغرافية
العنوان: Incidence of Plasmodium falciparum malaria infection in 6-month to 45-year-olds on selected areas of Bioko Island, Equatorial Guinea.
المؤلفون: Nchama VUNN; Ministry of Health and Social Welfare, Equatorial Guinea (EGMOHSW), Malabo, Equatorial Guinea.; Medical Care Development International (MCDI), Silver Spring, USA., Said AH; Medical Care Development International (MCDI), Silver Spring, USA. ahamad@ihi.or.tz.; Ifakara Health Institute, Dar es Salaam, Tanzania. ahamad@ihi.or.tz., Mtoro A; Medical Care Development International (MCDI), Silver Spring, USA.; Ifakara Health Institute, Dar es Salaam, Tanzania., Bidjimi GO; Ministry of Health and Social Welfare, Equatorial Guinea (EGMOHSW), Malabo, Equatorial Guinea.; Medical Care Development International (MCDI), Silver Spring, USA., Owono MA; Ministry of Health and Social Welfare, Equatorial Guinea (EGMOHSW), Malabo, Equatorial Guinea.; Medical Care Development International (MCDI), Silver Spring, USA., Maye ERM; Ministry of Health and Social Welfare, Equatorial Guinea (EGMOHSW), Malabo, Equatorial Guinea.; Medical Care Development International (MCDI), Silver Spring, USA., Mangue MEO; Ministry of Health and Social Welfare, Equatorial Guinea (EGMOHSW), Malabo, Equatorial Guinea.; Medical Care Development International (MCDI), Silver Spring, USA., Okomo GNN; Ministry of Health and Social Welfare, Equatorial Guinea (EGMOHSW), Malabo, Equatorial Guinea.; Medical Care Development International (MCDI), Silver Spring, USA., Pasialo BEN; Ministry of Health and Social Welfare, Equatorial Guinea (EGMOHSW), Malabo, Equatorial Guinea.; Medical Care Development International (MCDI), Silver Spring, USA., Ondo DM; Ministry of Health and Social Welfare, Equatorial Guinea (EGMOHSW), Malabo, Equatorial Guinea.; Medical Care Development International (MCDI), Silver Spring, USA., Lopez MA; Ministry of Health and Social Welfare, Equatorial Guinea (EGMOHSW), Malabo, Equatorial Guinea.; Medical Care Development International (MCDI), Silver Spring, USA., Mochomuemue FL; Ministry of Health and Social Welfare, Equatorial Guinea (EGMOHSW), Malabo, Equatorial Guinea.; Medical Care Development International (MCDI), Silver Spring, USA., Obono MO; Ministry of Health and Social Welfare, Equatorial Guinea (EGMOHSW), Malabo, Equatorial Guinea.; Medical Care Development International (MCDI), Silver Spring, USA., Besaha JCM; Ministry of Health and Social Welfare, Equatorial Guinea (EGMOHSW), Malabo, Equatorial Guinea.; Medical Care Development International (MCDI), Silver Spring, USA., Chuquiyauri R; Medical Care Development International (MCDI), Silver Spring, USA.; Sanaria Inc., Rockville, USA., Jongo SA; Medical Care Development International (MCDI), Silver Spring, USA., Kamaka K; Medical Care Development International (MCDI), Silver Spring, USA.; Ifakara Health Institute, Dar es Salaam, Tanzania., Kibondo UA; Ifakara Health Institute, Dar es Salaam, Tanzania., Athuman T; Ifakara Health Institute, Dar es Salaam, Tanzania., Falla CC; Medical Care Development International (MCDI), Silver Spring, USA., Eyono JNM; Medical Care Development International (MCDI), Silver Spring, USA., Smith JM; Medical Care Development International (MCDI), Silver Spring, USA., García GA; Medical Care Development International (MCDI), Silver Spring, USA., Raso J; Ministry of Health and Social Welfare, Equatorial Guinea (EGMOHSW), Malabo, Equatorial Guinea.; Medical Care Development International (MCDI), Silver Spring, USA., Nyakarungu E; Medical Care Development International (MCDI), Silver Spring, USA.; Ifakara Health Institute, Dar es Salaam, Tanzania., Mpina M; Ifakara Health Institute, Dar es Salaam, Tanzania.; Swiss Tropical and Public Health Institute (Swiss TPH), Basel, Switzerland.; University of Basel, Basel, Switzerland., Schindler T; Swiss Tropical and Public Health Institute (Swiss TPH), Basel, Switzerland.; University of Basel, Basel, Switzerland., Daubenberger C; Swiss Tropical and Public Health Institute (Swiss TPH), Basel, Switzerland.; University of Basel, Basel, Switzerland., Lemiale L; Sanaria Inc., Rockville, USA., Billingsley PF; Sanaria Inc., Rockville, USA., Sim BKL; Sanaria Inc., Rockville, USA., Richie TL; Sanaria Inc., Rockville, USA., Church LWP; Sanaria Inc., Rockville, USA., Olotu A; Medical Care Development International (MCDI), Silver Spring, USA.; Ifakara Health Institute, Dar es Salaam, Tanzania., Tanner M; Swiss Tropical and Public Health Institute (Swiss TPH), Basel, Switzerland.; University of Basel, Basel, Switzerland., Hoffman SL; Sanaria Inc., Rockville, USA., Abdulla S; Ifakara Health Institute, Dar es Salaam, Tanzania.
المصدر: Malaria journal [Malar J] 2021 Jul 20; Vol. 20 (1), pp. 322. Date of Electronic Publication: 2021 Jul 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101139802 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2875 (Electronic) Linking ISSN: 14752875 NLM ISO Abbreviation: Malar J Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2002-
مواضيع طبية MeSH: Malaria, Falciparum/*epidemiology, Adolescent ; Adult ; Child ; Child, Preschool ; Equatorial Guinea/epidemiology ; Humans ; Incidence ; Infant ; Malaria, Falciparum/parasitology ; Socioeconomic Factors ; Young Adult
مستخلص: Background: Extensive malaria control measures have been implemented on Bioko Island, Equatorial Guinea over the past 16 years, reducing parasite prevalence and malaria-related morbidity and mortality, but without achieving elimination. Malaria vaccines offer hope for reducing the burden to zero. Three phase 1/2 studies have been conducted successfully on Bioko Island to evaluate the safety and efficacy of whole Plasmodium falciparum (Pf) sporozoite (SPZ) malaria vaccines. A large, pivotal trial of the safety and efficacy of the radiation-attenuated Sanaria ® PfSPZ Vaccine against P. falciparum is planned for 2022. This study assessed the incidence of malaria at the phase 3 study site and characterized the influence of socio-demographic factors on the burden of malaria to guide trial design.
Methods: A cohort of 240 randomly selected individuals aged 6 months to 45 years from selected areas of North Bioko Province, Bioko Island, was followed for 24 weeks after clearance of parasitaemia. Assessment of clinical presentation consistent with malaria and thick blood smears were performed every 2 weeks. Incidence of first and multiple malaria infections per person-time of follow-up was estimated, compared between age groups, and examined for associated socio-demographic risk factors.
Results: There were 58 malaria infection episodes observed during the follow up period, including 47 first and 11 repeat infections. The incidence of malaria was 0.25 [95% CI (0.19, 0.32)] and of first malaria was 0.23 [95% CI (0.17, 0.30)] per person per 24 weeks (0.22 in 6-59-month-olds, 0.26 in 5-17-year-olds, 0.20 in 18-45-year-olds). Incidence of first malaria with symptoms was 0.13 [95% CI (0.09, 0.19)] per person per 24 weeks (0.16 in 6-59-month-olds, 0.10 in 5-17-year-olds, 0.11 in 18-45-year-olds). Multivariate assessment showed that study area, gender, malaria positivity at screening, and household socioeconomic status independently predicted the observed incidence of malaria.
Conclusion: Despite intensive malaria control efforts on Bioko Island, local transmission remains and is spread evenly throughout age groups. These incidence rates indicate moderate malaria transmission which may be sufficient to support future larger trials of PfSPZ Vaccine. The long-term goal is to conduct mass vaccination programmes to halt transmission and eliminate P. falciparum malaria.
(© 2021. The Author(s).)
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فهرسة مساهمة: Keywords: Bioko Island; Equatorial Guinea; Incidence; Malabo; Malaria; PfSPZ Vaccine; Plasmodium falciparum
تواريخ الأحداث: Date Created: 20210721 Date Completed: 20211105 Latest Revision: 20211105
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8290541
DOI: 10.1186/s12936-021-03850-8
PMID: 34284778
قاعدة البيانات: MEDLINE
الوصف
تدمد:1475-2875
DOI:10.1186/s12936-021-03850-8