دورية أكاديمية
Development of a Continuous Flow Synthesis of 2-Substituted Azetines and 3-Substituted Azetidines by Using a Common Synthetic Precursor.
| العنوان: | Development of a Continuous Flow Synthesis of 2-Substituted Azetines and 3-Substituted Azetidines by Using a Common Synthetic Precursor. |
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| المؤلفون: | Colella M; FLAME-Lab, Flow Chemistry and Microreactor Technology Laboratory, Department of Pharmacy - Drug Sciences, University of Bari 'A. Moro', Via E. Orabona 4, 70125 Bari, Italy., Musci P; FLAME-Lab, Flow Chemistry and Microreactor Technology Laboratory, Department of Pharmacy - Drug Sciences, University of Bari 'A. Moro', Via E. Orabona 4, 70125 Bari, Italy., Cannillo D; FLAME-Lab, Flow Chemistry and Microreactor Technology Laboratory, Department of Pharmacy - Drug Sciences, University of Bari 'A. Moro', Via E. Orabona 4, 70125 Bari, Italy., Spennacchio M; FLAME-Lab, Flow Chemistry and Microreactor Technology Laboratory, Department of Pharmacy - Drug Sciences, University of Bari 'A. Moro', Via E. Orabona 4, 70125 Bari, Italy., Aramini A; Department of Discovery, Dompé Farmaceutici S.p.A., Via Campo di Pile, L'Aquila 67100, Italy., Degennaro L; FLAME-Lab, Flow Chemistry and Microreactor Technology Laboratory, Department of Pharmacy - Drug Sciences, University of Bari 'A. Moro', Via E. Orabona 4, 70125 Bari, Italy., Luisi R; FLAME-Lab, Flow Chemistry and Microreactor Technology Laboratory, Department of Pharmacy - Drug Sciences, University of Bari 'A. Moro', Via E. Orabona 4, 70125 Bari, Italy. |
| المصدر: | The Journal of organic chemistry [J Org Chem] 2021 Oct 15; Vol. 86 (20), pp. 13943-13954. Date of Electronic Publication: 2021 Jul 22. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6904 (Electronic) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Columbus Oh : American Chemical Society Original Publication: Easton, Pa. [etc.] |
| مواضيع طبية MeSH: | Azetidines* , Azetines* |
| مستخلص: | The generation and functionalization, under continuous flow conditions, of two different lithiated four-membered aza-heterocycles is reported. N -Boc-3-iodoazetidine acts as a common synthetic platform for the genesis of C3-lithiated azetidine and C2-lithiated azetine depending on the lithiation agent. Flow technology enables easy handling of such lithiated intermediates at much higher temperatures compared to batch processing. Flow technology combined with cyclopentylmethyl ether as an environmentally responsible solvent allows us to address sustainability concerns. |
| المشرفين على المادة: | 0 (Azetidines) 0 (Azetines) |
| تواريخ الأحداث: | Date Created: 20210722 Date Completed: 20211022 Latest Revision: 20211022 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1021/acs.joc.1c01297 |
| PMID: | 34291947 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-6904 |
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| DOI: | 10.1021/acs.joc.1c01297 |