دورية أكاديمية
أعرض في EDS

Multinucleated Giant Cells Induced by a Silk Fibroin Construct Express Proinflammatory Agents: An Immunohistological Study.

التفاصيل البيبلوغرافية
العنوان: Multinucleated Giant Cells Induced by a Silk Fibroin Construct Express Proinflammatory Agents: An Immunohistological Study.
المؤلفون: Al-Maawi S; Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, FORM (Frankfurt Orofacial Regenerative Medicine) Lab, University Hospital Frankfurt Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany., Wang X; Department of Oral and Maxillofacial Surgery, Capital Medical University School of Stomatology, Beijing 100050, China., Sader R; Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, FORM (Frankfurt Orofacial Regenerative Medicine) Lab, University Hospital Frankfurt Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany., Götz W; Center of Dento-Maxillo-Facial Medicine, Department of Orthodontics, University of Bonn, Welschnonnenstrasse 17, 53111 Bonn, Germany., Motta A; Biotech Research Center and INSTM Unit, Department of Industrial Engineering, University of Trento, 38123 Trento, Italy., Migliaresi C; Biotech Research Center and INSTM Unit, Department of Industrial Engineering, University of Trento, 38123 Trento, Italy., Kirkpatrick CJ; Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, FORM (Frankfurt Orofacial Regenerative Medicine) Lab, University Hospital Frankfurt Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany., Ghanaati S; Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, FORM (Frankfurt Orofacial Regenerative Medicine) Lab, University Hospital Frankfurt Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
المصدر: Materials (Basel, Switzerland) [Materials (Basel)] 2021 Jul 19; Vol. 14 (14). Date of Electronic Publication: 2021 Jul 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101555929 Publication Model: Electronic Cited Medium: Print ISSN: 1996-1944 (Print) Linking ISSN: 19961944 NLM ISO Abbreviation: Materials (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: May 2010- : Basel, Switzerland : MDPI
Original Publication: Basel, Switzerland : Molecular Diversity Preservation International, 2008-2010.
مستخلص: Multinucleated giant cells (MNGCs) are frequently observed in the implantation areas of different biomaterials. The main aim of the present study was to analyze the long-term polarization pattern of the pro- and anti-inflammatory phenotypes of macrophages and MNGCs for 180 days to better understand their role in the success or failure of biomaterials. For this purpose, silk fibroin (SF) was implanted in a subcutaneous implantation model of Wistar rats as a model for biomaterial-induced MNGCs. A sham operation was used as a control for physiological wound healing. The expression of different inflammatory markers (proinflammatory M1: CCR-7, iNos; anti-inflammatory M2: CD-206, CD-163) and tartrate-resistant acid phosphatase (TRAP) and CD-68 were identified using immunohistochemical staining. The results showed significantly higher numbers of macrophages and MNGCs within the implantation bed of SF-expressed M1 markers, compared to M2 markers. Interestingly, the expression of proinflammatory markers was sustained over the long observation period of 180 days. By contrast, the control group showed a peak of M1 macrophages only on day 3. Thereafter, the inflammatory pattern shifted to M2 macrophages. No MNGCs were observed in the control group. To the best of our knowledge, this is study is the first to outline the persistence of pro-inflammatory MNGCs within the implantation bed of SF and to describe their long-term kinetics over 180 days. Clinically, these results are highly relevant to understand the role of biomaterial-induced MNGCs in the long term. These findings suggest that tailored physicochemical properties may be a key to avoiding extensive inflammatory reactions and achieving clinical success. Therefore, further research is needed to elucidate the correlation between proinflammatory MNGCs and the physicochemical characteristics of the implanted biomaterial.
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فهرسة مساهمة: Keywords: cellular response; disintegration; inflammation; multinucleated giant cells; silk fibroin
تواريخ الأحداث: Date Created: 20210724 Latest Revision: 20210729
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC8307820
DOI: 10.3390/ma14144038
PMID: 34300957
قاعدة البيانات: MEDLINE
الوصف
تدمد:1996-1944
DOI:10.3390/ma14144038