دورية أكاديمية
Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation.
العنوان: | Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation. |
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المؤلفون: | Abdel-Hakeem MS; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, Egypt., Manne S; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Beltra JC; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA, USA., Stelekati E; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Microbiology and Immunology, University of Miami, Miami, FL, USA., Chen Z; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Nzingha K; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ali MA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Johnson JL; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Microbiology, University of Pennsylvania, Philadelphia, PA, USA., Giles JR; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA, USA., Mathew D; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Greenplate AR; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Vahedi G; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, USA., Wherry EJ; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA. wherry@pennmedicine.upenn.edu.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. wherry@pennmedicine.upenn.edu.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA, USA. wherry@pennmedicine.upenn.edu. |
المصدر: | Nature immunology [Nat Immunol] 2021 Aug; Vol. 22 (8), pp. 1008-1019. Date of Electronic Publication: 2021 Jul 26. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: New York, NY : Nature America Inc. c2000- |
مواضيع طبية MeSH: | Antigens, Viral/*immunology , CD8-Positive T-Lymphocytes/*immunology , CD8-Positive T-Lymphocytes/*pathology , Immunologic Memory/*immunology , Lymphocytic Choriomeningitis/*immunology, Animals ; CD8-Positive T-Lymphocytes/cytology ; Cell Differentiation/immunology ; Cell Line ; Chlorocebus aethiops ; Cricetinae ; Epigenesis, Genetic/genetics ; Female ; Hepatocyte Nuclear Factor 1-alpha/metabolism ; Lymphocytic choriomeningitis virus/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Transcription, Genetic/genetics ; Vero Cells |
مستخلص: | Exhausted CD8 T cells (T (© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.) |
التعليقات: | Erratum in: Nat Immunol. 2021 Nov;22(11):1465. doi: 10.1038/s41590-021-01057-2. (PMID: 34588688) |
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معلومات مُعتمدة: | NHC-142832 Canada CIHR; P01 CA210944 United States CA NCI NIH HHS; U19 AI117950 United States AI NIAID NIH HHS; T32 CA009140 United States CA NCI NIH HHS; R01 AI155577 United States AI NIAID NIH HHS; U19 AI082630 United States AI NIAID NIH HHS; R01 AI115712 United States AI NIAID NIH HHS; P01 AI108545 United States AI NIAID NIH HHS; R01 AI105343 United States AI NIAID NIH HHS |
المشرفين على المادة: | 0 (Antigens, Viral) 0 (Hepatocyte Nuclear Factor 1-alpha) 0 (Hnf1a protein, mouse) |
تواريخ الأحداث: | Date Created: 20210727 Date Completed: 20210906 Latest Revision: 20240813 |
رمز التحديث: | 20240813 |
مُعرف محوري في PubMed: | PMC8323971 |
DOI: | 10.1038/s41590-021-00975-5 |
PMID: | 34312545 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1529-2916 |
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DOI: | 10.1038/s41590-021-00975-5 |