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Influence of FPGS, ABCC4, SLC29A1, and MTHFR genes on the pharmacogenomics of fluoropyrimidines in patients with gastrointestinal cancer from the Brazilian Amazon.

التفاصيل البيبلوغرافية
العنوان: Influence of FPGS, ABCC4, SLC29A1, and MTHFR genes on the pharmacogenomics of fluoropyrimidines in patients with gastrointestinal cancer from the Brazilian Amazon.
المؤلفون: Fernandes MR; Núcleo de Pesquisas Em Oncologia, Universidade Federal Do Pará, Belém, Pará, Brazil.; Hospital Ophir Loyola, Belém, Pará, Brazil., Rodrigues JCG; Núcleo de Pesquisas Em Oncologia, Universidade Federal Do Pará, Belém, Pará, Brazil., Dobbin EAF; Núcleo de Pesquisas Em Oncologia, Universidade Federal Do Pará, Belém, Pará, Brazil., Pastana LF; Núcleo de Pesquisas Em Oncologia, Universidade Federal Do Pará, Belém, Pará, Brazil., da Costa DF; Núcleo de Pesquisas Em Oncologia, Universidade Federal Do Pará, Belém, Pará, Brazil., Barra WF; Núcleo de Pesquisas Em Oncologia, Universidade Federal Do Pará, Belém, Pará, Brazil., Modesto AAC; Núcleo de Pesquisas Em Oncologia, Universidade Federal Do Pará, Belém, Pará, Brazil., de Assumpção PB; Núcleo de Pesquisas Em Oncologia, Universidade Federal Do Pará, Belém, Pará, Brazil., da Costa Silva AL; Centro de Genômica E Biologia de Sistemas, Instituto de Ciências Biológicas, Universidade Federal Do Pará, Belém, Pará, Brazil., Dos Santos SEB; Núcleo de Pesquisas Em Oncologia, Universidade Federal Do Pará, Belém, Pará, Brazil., Burbano RMR; Núcleo de Pesquisas Em Oncologia, Universidade Federal Do Pará, Belém, Pará, Brazil.; Hospital Ophir Loyola, Belém, Pará, Brazil., de Assumpção PP; Núcleo de Pesquisas Em Oncologia, Universidade Federal Do Pará, Belém, Pará, Brazil., Dos Santos NPC; Núcleo de Pesquisas Em Oncologia, Universidade Federal Do Pará, Belém, Pará, Brazil. npcsantos.ufpa@gmail.com.
المصدر: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2021 Nov; Vol. 88 (5), pp. 837-844. Date of Electronic Publication: 2021 Jul 31.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0843 (Electronic) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Publication: Berlin : Springer Verlag
Original Publication: Berlin, New York, Springer International.
مواضيع طبية MeSH: Antineoplastic Combined Chemotherapy Protocols/*pharmacology , Gastrointestinal Neoplasms/*drug therapy , Gastrointestinal Neoplasms/*genetics, Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Brazil ; Camptothecin/analogs & derivatives ; Camptothecin/pharmacology ; Equilibrative Nucleoside Transporter 1/genetics ; Female ; Fluorouracil/administration & dosage ; Fluorouracil/pharmacokinetics ; Fluorouracil/pharmacology ; Humans ; Leucovorin/pharmacology ; Male ; Methylenetetrahydrofolate Reductase (NADPH2)/genetics ; Middle Aged ; Multidrug Resistance-Associated Proteins/genetics ; Organoplatinum Compounds/pharmacology ; Peptide Synthases/genetics ; Pharmacogenomic Variants ; Polymorphism, Single Nucleotide
مستخلص: Purpose: Fluoropyrimidines are one of the most used drug class to treat cancer patients, although they show high levels of associated toxicity. This study analyzed 33 polymorphisms in 17 pharmacogenes involved with the pharmacogenomics of fluoropyrimidines, in gastrointestinal cancer patients undergoing fluoropyrimidine-based treatment in the Brazilian Amazon.
Methods: The study population was composed of 216 patients, 92 of whom have an anatomopathological diagnosis of gastric cancer and 124 of colorectal cancer. The single nucleotide polymorphisms (SNP) were genotyped by allelic discrimination using the TaqMan OpenArray Genotyping technology, with a panel of 32 customized assays, run in a QuantStudio ™ 12K Flex Real-Time PCR System (Applied Biosystems, Life Technologies, Carlsbad USA). Ancestry analysis was performed using 61 autosomal ancestry informative markers (AIMs).
Results: The study population show mean values of 48.1% European, 31.1% Amerindian, and 20.8% African ancestries. A significant risk association for general and severe toxicity was found in the rs4451422 of FPGS (p = 0.001; OR 3.40; CI 95% 1.65-7.00 and p = 0.006; OR 4.63; CI 95% 1.56-13.72, respectively) and the rs9524885 of ABCC4 (p = 0.023; OR 2.74; CI 95% 1.14-6.65 and p = 0.024; OR 5.36; IC 95% 1.24-23.11, respectively) genes. The rs760370 in the SLC29A1 gene (p = 0.009; OR 6.71; CI 95% 1.16-8.21) and the rs1801133 in the MTHFR toxicity (p = 0.023; OR 3.09; CI 95% 1.16-8.21) gene also demonstrated to be significant, although only for severe toxicity. The results found in this study did not have statistics analysis correction.
Conclusion: Four polymorphisms of the ABCC4, FPGS, SLC29A1, and MTHFR genes are likely to be potential predictive biomarkers for precision medicine in fluoropyrimidine-based treatments in the population of the Brazilian Amazon, which is constituted by a unique genetic background.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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فهرسة مساهمة: Keywords: ABCC4; FPGS; Fluoropyrimidine; MTHFR; Pharmacogenomics; SLC29A1
المشرفين على المادة: 0 (ABCC4 protein, human)
0 (Equilibrative Nucleoside Transporter 1)
0 (Multidrug Resistance-Associated Proteins)
0 (Organoplatinum Compounds)
0 (SLC29A1 protein, human)
EC 1.5.1.20 (MTHFR protein, human)
EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
EC 6.3.2.- (Peptide Synthases)
EC 6.3.2.17 (folylpolyglutamate synthetase)
Q573I9DVLP (Leucovorin)
U3P01618RT (Fluorouracil)
XT3Z54Z28A (Camptothecin)
SCR Protocol: Folfox protocol; IFL protocol
تواريخ الأحداث: Date Created: 20210731 Date Completed: 20220103 Latest Revision: 20220103
رمز التحديث: 20240829
DOI: 10.1007/s00280-021-04327-w
PMID: 34331561
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-0843
DOI:10.1007/s00280-021-04327-w