دورية أكاديمية

Associations between respiratory and vascular function in early childhood.

التفاصيل البيبلوغرافية
العنوان: Associations between respiratory and vascular function in early childhood.
المؤلفون: Hemstock EJ; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Shao J; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Zhao B; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Hall GL; Children's Lung Health, Wal-yan Respiratory Research Centre, Telethon Kids Institute, Nedlands, Western Australia, Australia.; School of Physiotherapy and Exercise Science, Curtin University, Bentley, Western Australia, Australia., Wheeler AJ; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia., Dharmage SC; School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia., Melody SM; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Dalton MF; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Foong RE; Children's Lung Health, Wal-yan Respiratory Research Centre, Telethon Kids Institute, Nedlands, Western Australia, Australia.; School of Physiotherapy and Exercise Science, Curtin University, Bentley, Western Australia, Australia., Williamson GJ; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Chappell KJ; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Abramson MJ; School of Public Health & Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Negishi K; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.; Sydney Medical School Nepean, The University of Sydney, Sydney, New South Wales, Australia., Johnston FH; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Zosky GR; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.; Tasmanian School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.
المصدر: Respirology (Carlton, Vic.) [Respirology] 2021 Nov; Vol. 26 (11), pp. 1060-1066. Date of Electronic Publication: 2021 Aug 02.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Blackwell Science Country of Publication: Australia NLM ID: 9616368 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1440-1843 (Electronic) Linking ISSN: 13237799 NLM ISO Abbreviation: Respirology Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Carlton, Vic. : Blackwell Science, c1996-
مواضيع طبية MeSH: Carotid Intima-Media Thickness* , Fires*, Adult ; Child ; Child, Preschool ; Female ; Humans ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; Pregnancy ; Prospective Studies ; Pulse Wave Analysis
مستخلص: Background and Objective: The link between respiratory and vascular health is well documented in adult populations. Impaired lung function is consistently associated with thicker arteries and higher incidence of cardiovascular disease. However, there are limited data on this relationship in young children and the studies that exist have focussed on populations at high risk of cardiorespiratory morbidity. We determined if an association exists between respiratory and cardiovascular function in young children and, if so, whether it is confounded by known cardiorespiratory risk factors.
Methods: Respiratory and vascular data from a prospective cohort study established to evaluate the health implications 3 years after coal mine fire smoke exposure in children aged 3-5 years were used. Respiratory function was measured using the forced oscillation technique and included resistance at 5 Hz (R 5 ), reactance at 5 Hz (X 5 ) and area under the reactance curve (AX). Vascular health was measured by carotid intima-media thickness (ultrasound) and pulse wave velocity (arterial tonometry). Regression analyses were used to examine the relationship between the respiratory Z-scores and cardiovascular measures. Subsequent analyses were adjusted for potential confounding by maternal smoking during pregnancy, maternal education and exposure to fine particulate matter <2.5 μm in aerodynamic diameter (PM 2.5 ).
Results: Peripheral lung function (X 5 and AX), but not respiratory system resistance (R 5 ), was associated with vascular function. Adjustment for maternal smoking, maternal education and early life exposure to PM 2.5 had minimal effect on these associations.
Conclusion: These observations suggest that peripheral lung stiffness is associated with vascular stiffness and that this relationship is established early in life.
(© 2021 Asian Pacific Society of Respirology.)
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فهرسة مساهمة: Keywords: early life; maternal education; particulate matter; respiratory function; smoking; vascular function
المشرفين على المادة: 0 (Particulate Matter)
تواريخ الأحداث: Date Created: 20210802 Date Completed: 20220104 Latest Revision: 20220104
رمز التحديث: 20240628
DOI: 10.1111/resp.14117
PMID: 34339550
قاعدة البيانات: MEDLINE
الوصف
تدمد:1440-1843
DOI:10.1111/resp.14117