دورية أكاديمية
أعرض في EDS

Effect of d-limonene and its derivatives on breast cancer in human trials: a scoping review and narrative synthesis.

التفاصيل البيبلوغرافية
العنوان: Effect of d-limonene and its derivatives on breast cancer in human trials: a scoping review and narrative synthesis.
المؤلفون: Chebet JJ; Department of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N Martin Ave, Tucson, AZ, 85724, USA., Ehiri JE; Department of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N Martin Ave, Tucson, AZ, 85724, USA., McClelland DJ; University of Arizona Health Sciences Library, University of Arizona, Tucson, AZ, USA., Taren D; Department of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N Martin Ave, Tucson, AZ, 85724, USA., Hakim IA; Department of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N Martin Ave, Tucson, AZ, 85724, USA. ihakim@arizona.edu.
المصدر: BMC cancer [BMC Cancer] 2021 Aug 06; Vol. 21 (1), pp. 902. Date of Electronic Publication: 2021 Aug 06.
نوع المنشور: Journal Article; Meta-Analysis; Review
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Antineoplastic Agents, Phytogenic/*therapeutic use , Breast Neoplasms/*drug therapy , Limonene/*therapeutic use, Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/pharmacology ; Breast Neoplasms/pathology ; Combined Modality Therapy ; Drug Monitoring ; Female ; Humans ; Limonene/chemistry ; Limonene/pharmacology ; Maximum Tolerated Dose ; Middle Aged ; Molecular Structure ; Treatment Outcome
مستخلص: Background: D-limonene and its derivatives have demonstrated potential chemopreventive and anticancer activity in preclinical and clinical studies. The aim of this scoping review was to assess and critically appraise current literature on the effect of these bioactive citrus peel compounds on breast cancer in human trials and to identify knowledge gaps for exploration in future studies.
Methods: This study followed a scoping review framework. Peer-reviewed journal articles were included if they reported the effect of d-limonene or its derivatives on breast cancer in human subjects. Articles were retrieved from academic databases - PubMed, EMBASE, CINAHL, Web of Science, and Cochrane reviews - and iteratively through review of bibliographies of relevant manuscripts. Titles and abstracts were appraised against the aforementioned inclusion criteria in a first round of screening. Through consensus meetings and full article review by authors, a final set of studies were selected. Results were reported according to the PRISMA extension for scoping reviews.
Results: Our search strategy yielded 367 records. Following screening and adjudication, five articles reporting on phase 1(n = 2), phase 2 (n = 2) and both trial phases (n = 1) were included as the final dataset for this review. Trials evaluating the effect of d-limonene (n = 2) showed it was well tolerated in subjects. One study (n = 43 participants) showed d-limonene concentrated in breast tissue (mean 41.3 μg/g tissue) and reduction in tumor cyclin D1 expression, which is associated with tumor proliferation arrest. This study did not show meaningful change in serum biomarkers associated with breast cancer, except for a statistically significant increase in insulin-like growth factor-1 (IGF-I) levels. While elevation of IGF-I is associated with increased cancer risk, the clinical implication of this study remains uncertain given its short duration. Trials with perillyl alcohol (n = 3) showed low tolerance and no effect on breast cancer.
Conclusion: This review demonstrated a dearth of clinical studies exploring the effect of d-limonene and its derivatives on breast cancer. Limited literature suggests d-limonene is safe and tolerable in human subjects compared to its derivative, perillyl alcohol. Our review demonstrates the need for additional well-powered placebo-controlled trials that assess d-limonene's efficacy on breast cancer compared to other therapies.
(© 2021. The Author(s).)
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فهرسة مساهمة: Keywords: Breast cancer; Chemopreventive; Citrus peel; D-limonene; Perillyl alcohol; Scoping review
المشرفين على المادة: 0 (Antineoplastic Agents, Phytogenic)
9MC3I34447 (Limonene)
تواريخ الأحداث: Date Created: 20210807 Date Completed: 20211018 Latest Revision: 20240403
رمز التحديث: 20240403
مُعرف محوري في PubMed: PMC8349000
DOI: 10.1186/s12885-021-08639-1
PMID: 34362338
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2407
DOI:10.1186/s12885-021-08639-1