دورية أكاديمية
Prenatal and infant antibiotic exposure and childhood growth, obesity and cardiovascular risk factors: The Rhea mother-child cohort study, Crete, Greece.
| العنوان: | Prenatal and infant antibiotic exposure and childhood growth, obesity and cardiovascular risk factors: The Rhea mother-child cohort study, Crete, Greece. |
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| المؤلفون: | Margetaki K; Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.; Department of Preventive Medicine, Division of Environmental Health, University of Southern California, Los Angeles, California, USA., Stratakis N; Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.; Department of Preventive Medicine, Division of Environmental Health, University of Southern California, Los Angeles, California, USA., Roumeliotaki T; Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece., Karachaliou M; Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece., Alexaki M; Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece., Kogevinas M; Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.; Centro de Investigación Biomédicaen Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain., Chatzi L; Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.; Department of Preventive Medicine, Division of Environmental Health, University of Southern California, Los Angeles, California, USA., Vafeiadi M; Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece. |
| المصدر: | Pediatric obesity [Pediatr Obes] 2022 Jan; Vol. 17 (1), pp. e12843. Date of Electronic Publication: 2021 Aug 09. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell for the International Association for the Study of Obesity Country of Publication: England NLM ID: 101572033 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-6310 (Electronic) Linking ISSN: 20476302 NLM ISO Abbreviation: Pediatr Obes Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, UK : Wiley-Blackwell for the International Association for the Study of Obesity |
| مواضيع طبية MeSH: | Pediatric Obesity*/chemically induced , Pediatric Obesity*/epidemiology , Prenatal Exposure Delayed Effects*/chemically induced , Prenatal Exposure Delayed Effects*/epidemiology , Rheiformes*, Animals ; Anti-Bacterial Agents/adverse effects ; Body Mass Index ; Child ; Cohort Studies ; Female ; Greece/epidemiology ; Humans ; Infant ; Mother-Child Relations ; Pregnancy ; Risk Factors |
| مستخلص: | Background: Early-life antibiotic use has been hypothesized to promote weight gain and increase the risk of childhood obesity. Objectives: To examine the associations of prenatal and infant antibiotics with childhood growth, adiposity and cardiometabolic traits in the Greek Rhea cohort. Methods: We used data from 747 mother-child pairs with anthropometric measurements drawn from medical records or measured at 4 and 6 years of age. Antibiotic exposure was assessed by maternal report during pregnancy and at the first year of life. Children were classified as exposed to antibiotics prenatally if the mother received at least one course of oral antibiotics during pregnancy and postnatally if the mother reported that the child received at least one oral antibiotic treatment during the first year of life. Outcomes included repeated weight, body mass index (BMI), waist circumference, body fat (%), total cholesterol and blood pressure. We applied mixed effects, linear and log-binomial regression models after adjusting for important covariates. Results: Around 14.6% of the participating children were prenatally exposed to antibiotics and 32.4% received antibiotics during the first year of life. Prenatal exposure to antibiotics was associated with a twofold increase in the risk for obesity (risk ratio [RR]; 95% confidence interval [CI]: 2.09 [1.58, 2.76]) and abdominal obesity (RR [95% CI]: 2.56 [1.89, 3.47]) at 6 years. Postnatal exposure to antibiotics was associated with increased weight (beta [95% CI]: 00.25 [0.06, 0.44]) and BMI (beta [95% CI]: 0.23 [0.003, 0.45]) SD scores from 2 to 7 years of life. Conclusion: Early-life antibiotic use was associated with accelerated childhood growth and higher adiposity. (© 2021 World Obesity Federation.) |
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| فهرسة مساهمة: | Keywords: blood pressure; growth; obesity; postnatal antibiotics; prenatal antibiotics |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) |
| تواريخ الأحداث: | Date Created: 20210809 Date Completed: 20220110 Latest Revision: 20220110 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/ijpo.12843 |
| PMID: | 34369080 |
| قاعدة البيانات: | MEDLINE |
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