دورية أكاديمية
Hybrid lipid core chitosan-TPGS shell nanocomposites as a promising integrated nanoplatform for enhanced oral delivery of sulpiride in depressive disorder therapy.
| العنوان: | Hybrid lipid core chitosan-TPGS shell nanocomposites as a promising integrated nanoplatform for enhanced oral delivery of sulpiride in depressive disorder therapy. |
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| المؤلفون: | Mohyeldin SM; Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt. Electronic address: salma.eldin@alexu.edu.eg., Samy WM; Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt., Ragab D; Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt., Abdelmonsif DA; Department of Medical Biochemistry, Faculty of Medicine, Alexandria University, Alexandria, Egypt; Centre of Excellence for Research in Regenerative Medicine and Applications (CERRMA), Faculty of Medicine, Alexandria University, Alexandria, Egypt., Aly RG; Department of Surgical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Elgindy NA; Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt; College of Pharmacy, Arab Academy for Science, Technology & Maritime Transport, Alexandria, Egypt. |
| المصدر: | International journal of biological macromolecules [Int J Biol Macromol] 2021 Oct 01; Vol. 188, pp. 432-449. Date of Electronic Publication: 2021 Aug 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Guildford, Eng., IPC Science and Technology Press. |
| مواضيع طبية MeSH: | Chitosan/*chemistry , Depressive Disorder/*drug therapy , Nanocomposites/*chemistry , Sulpiride/*pharmacology, Administration, Oral ; Caco-2 Cells ; Chitosan/pharmacology ; Humans ; Lipids/chemistry ; Lipids/pharmacology ; Sulpiride/chemistry ; Vitamin E/chemistry ; Vitamin E/pharmacology |
| مستخلص: | Sulpiride (SUL), a benzamide derivative, acts as a multitarget drug with extensive biological properties. However, being a P-glycoprotein efflux substrate with a limited oral bioavailability imposes a challenge to its clinical efficacy. The current research explores the impact of tailored hybrid lipid-polysaccharide nanocomposites in augmenting the biological performance of SUL. Chitosan-graft-tocopherol polyethylene glycol 1000 succinate (TPGS) copolymers were synthesized and integrated as a polysaccharide shell into a SUL-loaded lipid nanocore. The optimized nanohybrids revealed a nanocore-shell structure with 110.1 nm particle size, 23.7 mV zeta potential, 85.42% encapsulation efficiency, a pH-dependent-release profile, and an acceptable mucoadhesive tendency. Employing TPGS into the chitosan backbone alleviated the cellular internalization of nanohybrids into the Caco-2 intestinal cells and hence increased the intestinal permeation and the oral bioavailability of SUL by 3.3, and 8.7-folds, respectively. Reserpine-induced depression rat model confirmed the superior antidepressant activity of nanohybrids, compared with free SUL and a marketed product. The nanohybrids exhibited 1.87- and 1.47-folds enhancement in both serotonin and dopamine levels, respectively. Additionally, nanohybrids were shown to attenuate brain oxidative stress state and SUL irritant effect on different body tissues. Overall, the newly tailored nanohybrids pave the way for an advance in the field of oral drug delivery. (Copyright © 2021 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Chitosan-TPGS; Depression; Nanohybrids; Oral bioavailability; Sulpiride; Toxicity |
| المشرفين على المادة: | 0 (Lipids) 1406-18-4 (Vitamin E) 7MNE9M8287 (Sulpiride) 9012-76-4 (Chitosan) O03S90U1F2 (tocophersolan) |
| تواريخ الأحداث: | Date Created: 20210810 Date Completed: 20211215 Latest Revision: 20211215 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.ijbiomac.2021.08.035 |
| PMID: | 34375663 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0003 |
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| DOI: | 10.1016/j.ijbiomac.2021.08.035 |