دورية أكاديمية
أعرض في EDS

Protracted yet Coordinated Differentiation of Long-Lived SARS-CoV-2-Specific CD8 + T Cells during Convalescence.

التفاصيل البيبلوغرافية
العنوان: Protracted yet Coordinated Differentiation of Long-Lived SARS-CoV-2-Specific CD8 + T Cells during Convalescence.
المؤلفون: Ma T; Gladstone Institutes, San Francisco, CA.; Department of Urology, University of California San Francisco, San Francisco, CA., Ryu H; Vaccine and Infectious Disease Division, Fred Hutchison Cancer Research Center, Seattle, WA., McGregor M; Gladstone Institutes, San Francisco, CA.; Department of Urology, University of California San Francisco, San Francisco, CA., Babcock B; Department of Medicine, Lowance Center for Human Immunology, Emory Vaccine Center, Emory University, Atlanta, GA., Neidleman J; Gladstone Institutes, San Francisco, CA.; Department of Urology, University of California San Francisco, San Francisco, CA., Xie G; Gladstone Institutes, San Francisco, CA.; Department of Urology, University of California San Francisco, San Francisco, CA., George AF; Gladstone Institutes, San Francisco, CA.; Department of Urology, University of California San Francisco, San Francisco, CA., Frouard J; Gladstone Institutes, San Francisco, CA.; Department of Urology, University of California San Francisco, San Francisco, CA., Murray V; Zuckerberg San Francisco General Hospital and the University of California, San Francisco, CA; and., Gill G; Zuckerberg San Francisco General Hospital and the University of California, San Francisco, CA; and., Ghosn E; Department of Medicine, Lowance Center for Human Immunology, Emory Vaccine Center, Emory University, Atlanta, GA.; Department of Pediatrics, Lowance Center for Human Immunology, Emory Vaccine Center, Emory University, Atlanta, GA., Newell EW; Vaccine and Infectious Disease Division, Fred Hutchison Cancer Research Center, Seattle, WA., Lee SA; Zuckerberg San Francisco General Hospital and the University of California, San Francisco, CA; and nadia.roan@gladstone.ucsf.edu sulggi.lee@ucsf.edu., Roan NR; Gladstone Institutes, San Francisco, CA; nadia.roan@gladstone.ucsf.edu sulggi.lee@ucsf.edu.; Department of Urology, University of California San Francisco, San Francisco, CA.
المصدر: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2021 Sep 01; Vol. 207 (5), pp. 1344-1356. Date of Electronic Publication: 2021 Aug 13.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: Bethesda, MD : American Association of Immunologists
Original Publication: Baltimore : Williams & Wilkins, c1950-
مواضيع طبية MeSH: Convalescence*, CD8-Positive T-Lymphocytes/*immunology , COVID-19/*immunology , SARS-CoV-2/*immunology, CD8-Positive T-Lymphocytes/pathology ; Humans ; Longitudinal Studies
مستخلص: CD8 + T cells can potentiate long-lived immunity against COVID-19. We screened longitudinally-sampled convalescent human donors against SARS-CoV-2 tetramers and identified a participant with an immunodominant response against residues 322 to 311 of nucleocapsid (Nuc 322-331 ), a peptide conserved in all variants of concern reported to date. We conducted 38-parameter cytometry by time of flight on tetramer-identified Nuc 322-331 -specific CD8 + T cells and on CD4 + and CD8 + T cells recognizing the entire nucleocapsid and spike proteins, and took 32 serological measurements. We discovered a coordination of the Nuc 322-331 -specific CD8 + T response with both the CD4 + T cell and Ab pillars of adaptive immunity. Over the approximately six month period of convalescence monitored, we observed a slow and progressive decrease in the activation state and polyfunctionality of Nuc 322-331 -specific CD8 + T cells, accompanied by an increase in their lymph node-homing and homeostatic proliferation potential. These results suggest that following a typical case of mild COVID-19, SARS-CoV-2-specific CD8 + T cells not only persist but continuously differentiate in a coordinated fashion well into convalescence into a state characteristic of long-lived, self-renewing memory.
(Copyright © 2021 by The American Association of Immunologists, Inc.)
التعليقات: Update of: bioRxiv. 2021 Apr 29:2021.04.28.441880. doi: 10.1101/2021.04.28.441880. (PMID: 33948597)
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معلومات مُعتمدة: 75N92020D00005 United States HL NHLBI NIH HHS; S10 1S10OD018040-01 United States OD NIH HHS; P30 DK063720 United States DK NIDDK NIH HHS; T32 AI007334 United States AI NIAID NIH HHS; 75N99020D00005 United States OF ORFDO NIH HHS; P30 AI027763 United States AI NIAID NIH HHS; S10 OD018040 United States OD NIH HHS; 75N93023D00005 United States AI NIAID NIH HHS; 75N93020C00005 United States AI NIAID NIH HHS; 75N93022D00005 United States AI NIAID NIH HHS; R01 AI121207 United States AI NIAID NIH HHS; 75N95020D00005 United States DA NIDA NIH HHS
تواريخ الأحداث: Date Created: 20210814 Date Completed: 20210830 Latest Revision: 20240626
رمز التحديث: 20240626
مُعرف محوري في PubMed: PMC8763019
DOI: 10.4049/jimmunol.2100465
PMID: 34389625
قاعدة البيانات: MEDLINE
الوصف
تدمد:1550-6606
DOI:10.4049/jimmunol.2100465